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E0RD21

- E0RD21_PAEP6

UniProt

E0RD21 - E0RD21_PAEP6

Protein

Malate dehydrogenase

Gene

mdh

Organism
Paenibacillus polymyxa (strain E681)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 23 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei36 – 361NADUniRule annotation
    Binding sitei87 – 871SubstrateUniRule annotation
    Binding sitei93 – 931SubstrateUniRule annotation
    Binding sitei100 – 1001NADUniRule annotation
    Binding sitei125 – 1251SubstrateUniRule annotation
    Binding sitei156 – 1561SubstrateUniRule annotation
    Active sitei180 – 1801Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi12 – 176NADUniRule annotation
    Nucleotide bindingi123 – 1253NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciPPOL349520:GH6J-1582-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:PPE_01588Imported
    OrganismiPaenibacillus polymyxa (strain E681)Imported
    Taxonomic identifieri349520 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
    ProteomesiUP000002227: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliE0RD21.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000213794.
    KOiK00024.
    OMAiLMSAGMP.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_00487. Malate_dehydrog_3.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11540. PTHR11540. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSiPR00086. LLDHDRGNASE.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    E0RD21-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIQRKKISI VGAGFTGATT ALLLAQKELG DIVLIDIPQL ENPTKGKALD    50
    ILEAGPVEGF DSQITGTSNY EDAANSDIVI ITAGIARKPG MSRDDLVNTN 100
    AGIVKSVCEN VKKYAPDSIV IILSNPVDAM TYTAYQTLGF PKNRVIGQSG 150
    VLDTARYCTF IAQELNVSVE DVRGFVMGGH GDDMVPLVRY SSVGGIPIET 200
    LISQERIEAI VQRTRGGGGE IVNLLGNGSA YYAPAASLAQ MTEAIVKDKK 250
    RIIPVIAYLE GEYGYQDLFL GVPTLLGGNG IEKVFELELT AEEKAALDQS 300
    AESVRSVIKI VTV 313
    Length:313
    Mass (Da):33,355
    Last modified:November 2, 2010 - v1
    Checksum:i885EF14845F8779F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000154 Genomic DNA. Translation: ADM69427.1.
    RefSeqiYP_003869965.1. NC_014483.1.

    Genome annotation databases

    EnsemblBacteriaiADM69427; ADM69427; PPE_01588.
    GeneIDi9774341.
    KEGGippy:PPE_01588.
    PATRICi42408854. VBIPaePol94484_1570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000154 Genomic DNA. Translation: ADM69427.1 .
    RefSeqi YP_003869965.1. NC_014483.1.

    3D structure databases

    ProteinModelPortali E0RD21.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADM69427 ; ADM69427 ; PPE_01588 .
    GeneIDi 9774341.
    KEGGi ppy:PPE_01588.
    PATRICi 42408854. VBIPaePol94484_1570.

    Phylogenomic databases

    HOGENOMi HOG000213794.
    KOi K00024.
    OMAi LMSAGMP.

    Enzyme and pathway databases

    BioCyci PPOL349520:GH6J-1582-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_00487. Malate_dehydrog_3.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR011275. Malate_DH_type3.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11540. PTHR11540. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    PRINTSi PR00086. LLDHDRGNASE.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the polymyxin-producing plant-probiotic rhizobacterium Paenibacillus polymyxa E681."
      Kim J.F., Jeong H., Park S.Y., Kim S.B., Park Y.K., Choi S.K., Ryu C.M., Hur C.G., Ghim S.Y., Oh T.K., Kim J.J., Park C.S., Park S.H.
      J. Bacteriol. 192:6103-6104(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: E681Imported.

    Entry informationi

    Entry nameiE0RD21_PAEP6
    AccessioniPrimary (citable) accession number: E0RD21
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 23 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3