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E0RD21 (E0RD21_PAEP6) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Malate dehydrogenase HAMAP-Rule MF_00487

EC=1.1.1.37 HAMAP-Rule MF_00487
Gene names
Name:mdh HAMAP-Rule MF_00487
Ordered Locus Names:PPE_01588 EMBL ADM69427.1
OrganismPaenibacillus polymyxa (strain E681) [Complete proteome] [HAMAP] EMBL ADM69427.1
Taxonomic identifier349520 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus

Protein attributes

Sequence length313 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_00487 SAAS SAAS011275

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. HAMAP-Rule MF_00487 SAAS SAAS011275

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 3 family. HAMAP-Rule MF_00487

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding12 – 176NAD By similarity HAMAP-Rule MF_00487
Nucleotide binding123 – 1253NAD By similarity HAMAP-Rule MF_00487

Sites

Active site1801Proton acceptor By similarity HAMAP-Rule MF_00487
Binding site361NAD By similarity HAMAP-Rule MF_00487
Binding site871Substrate By similarity HAMAP-Rule MF_00487
Binding site931Substrate By similarity HAMAP-Rule MF_00487
Binding site1001NAD By similarity HAMAP-Rule MF_00487
Binding site1251Substrate By similarity HAMAP-Rule MF_00487
Binding site1561Substrate By similarity HAMAP-Rule MF_00487

Sequences

Sequence LengthMass (Da)Tools
E0RD21 [UniParc].

Last modified November 2, 2010. Version 1.
Checksum: 885EF14845F8779F

FASTA31333,355
        10         20         30         40         50         60 
MSIQRKKISI VGAGFTGATT ALLLAQKELG DIVLIDIPQL ENPTKGKALD ILEAGPVEGF 

        70         80         90        100        110        120 
DSQITGTSNY EDAANSDIVI ITAGIARKPG MSRDDLVNTN AGIVKSVCEN VKKYAPDSIV 

       130        140        150        160        170        180 
IILSNPVDAM TYTAYQTLGF PKNRVIGQSG VLDTARYCTF IAQELNVSVE DVRGFVMGGH 

       190        200        210        220        230        240 
GDDMVPLVRY SSVGGIPIET LISQERIEAI VQRTRGGGGE IVNLLGNGSA YYAPAASLAQ 

       250        260        270        280        290        300 
MTEAIVKDKK RIIPVIAYLE GEYGYQDLFL GVPTLLGGNG IEKVFELELT AEEKAALDQS 

       310 
AESVRSVIKI VTV 

« Hide

References

[1]"Genome sequence of the polymyxin-producing plant-probiotic rhizobacterium Paenibacillus polymyxa E681."
Kim J.F., Jeong H., Park S.Y., Kim S.B., Park Y.K., Choi S.K., Ryu C.M., Hur C.G., Ghim S.Y., Oh T.K., Kim J.J., Park C.S., Park S.H.
J. Bacteriol. 192:6103-6104(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: E681 EMBL ADM69427.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000154 Genomic DNA. Translation: ADM69427.1.
RefSeqYP_003869965.1. NC_014483.1.

3D structure databases

ProteinModelPortalE0RD21.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADM69427; ADM69427; PPE_01588.
GeneID9774341.
KEGGppy:PPE_01588.
PATRIC42408854. VBIPaePol94484_1570.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000213794.
KOK00024.
OMASANEHEK.

Enzyme and pathway databases

BioCycPPOL349520:GH6J-1582-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_00487. Malate_dehydrog_3.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11540. PTHR11540. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSPR00086. LLDHDRGNASE.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01763. MalateDH_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameE0RD21_PAEP6
AccessionPrimary (citable) accession number: E0RD21
Entry history
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: February 19, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)