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E0RD21

- E0RD21_PAEP6

UniProt

E0RD21 - E0RD21_PAEP6

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Protein

Malate dehydrogenase

Gene

mdh

Organism
Paenibacillus polymyxa (strain E681)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361NADUniRule annotation
Binding sitei87 – 871SubstrateUniRule annotation
Binding sitei93 – 931SubstrateUniRule annotation
Binding sitei100 – 1001NADUniRule annotation
Binding sitei125 – 1251SubstrateUniRule annotation
Binding sitei156 – 1561SubstrateUniRule annotation
Active sitei180 – 1801Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 176NADUniRule annotation
Nucleotide bindingi123 – 1253NADUniRule annotation

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotationSAAS annotation

Keywords - Ligandi

NADUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPPOL349520:GH6J-1582-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdhUniRule annotation
Ordered Locus Names:PPE_01588Imported
OrganismiPaenibacillus polymyxa (strain E681)Imported
Taxonomic identifieri349520 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
ProteomesiUP000002227: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE0RD21.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 3 family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000213794.
KOiK00024.
OMAiLMSAGMP.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

E0RD21-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIQRKKISI VGAGFTGATT ALLLAQKELG DIVLIDIPQL ENPTKGKALD
60 70 80 90 100
ILEAGPVEGF DSQITGTSNY EDAANSDIVI ITAGIARKPG MSRDDLVNTN
110 120 130 140 150
AGIVKSVCEN VKKYAPDSIV IILSNPVDAM TYTAYQTLGF PKNRVIGQSG
160 170 180 190 200
VLDTARYCTF IAQELNVSVE DVRGFVMGGH GDDMVPLVRY SSVGGIPIET
210 220 230 240 250
LISQERIEAI VQRTRGGGGE IVNLLGNGSA YYAPAASLAQ MTEAIVKDKK
260 270 280 290 300
RIIPVIAYLE GEYGYQDLFL GVPTLLGGNG IEKVFELELT AEEKAALDQS
310
AESVRSVIKI VTV
Length:313
Mass (Da):33,355
Last modified:November 2, 2010 - v1
Checksum:i885EF14845F8779F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000154 Genomic DNA. Translation: ADM69427.1.
RefSeqiYP_003869965.1. NC_014483.1.

Genome annotation databases

EnsemblBacteriaiADM69427; ADM69427; PPE_01588.
GeneIDi9774341.
KEGGippy:PPE_01588.
PATRICi42408854. VBIPaePol94484_1570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000154 Genomic DNA. Translation: ADM69427.1 .
RefSeqi YP_003869965.1. NC_014483.1.

3D structure databases

ProteinModelPortali E0RD21.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADM69427 ; ADM69427 ; PPE_01588 .
GeneIDi 9774341.
KEGGi ppy:PPE_01588.
PATRICi 42408854. VBIPaePol94484_1570.

Phylogenomic databases

HOGENOMi HOG000213794.
KOi K00024.
OMAi LMSAGMP.

Enzyme and pathway databases

BioCyci PPOL349520:GH6J-1582-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the polymyxin-producing plant-probiotic rhizobacterium Paenibacillus polymyxa E681."
    Kim J.F., Jeong H., Park S.Y., Kim S.B., Park Y.K., Choi S.K., Ryu C.M., Hur C.G., Ghim S.Y., Oh T.K., Kim J.J., Park C.S., Park S.H.
    J. Bacteriol. 192:6103-6104(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: E681Imported.

Entry informationi

Entry nameiE0RD21_PAEP6
AccessioniPrimary (citable) accession number: E0RD21
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3