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E0RD20

- E0RD20_PAEP6

UniProt

E0RD20 - E0RD20_PAEP6

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Protein

Isocitrate dehydrogenase [NADP]

Gene
icd, PPE_01587
Organism
Paenibacillus polymyxa (strain E681)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciPPOL349520:GH6J-1581-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:PPE_01587Imported
OrganismiPaenibacillus polymyxa (strain E681)Imported
Taxonomic identifieri349520 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
ProteomesiUP000002227: Chromosome

Structurei

3D structure databases

ProteinModelPortaliE0RD20.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiIEFNERI.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0RD20-1 [UniParc]FASTAAdd to Basket

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MSFVLYPFIS EEEKELMAKF EKFELPTEGE KITIDNGQLQ VPNHPVIPFI    50
EGDGTGRDIW KASKRVLDAA VEKAYNGSKK IAWYEVFAGE KAFNTYGEWL 100
PNDTLEAIRE YIVAIKGPLT TPIGGGIRSL NVALRQELDL YVCLRPVRYF 150
NGVPSPVKRP ELVDMVIFRE NTEDIYAGIE YAEGSEDVKK VIQFLQQELG 200
VNKIRFPETS GIGIKPVSSE GSKRLVRAAI QYAVDHGRKS VTLVHKGNIM 250
KFTEGAFKNW GYEVAEEEFA DKVFTWAQYD VIKEKDGEDA ANAAQKAAED 300
AGKIIIKDAI ADIALQQVLT RPSEFDVIAT LNLNGDYLSD ALAAQVGGIG 350
IAPGANINYV TGHAIFEATH GTAPKYADKD VVNPGSVILS GVMLLEHLGW 400
KEAADLIYKG LETSINKKIV TYDFARLMDG ATQVKCSEFA DTIISNL 447
Length:447
Mass (Da):49,310
Last modified:November 2, 2010 - v1
Checksum:i4D3678D937FB68A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000154 Genomic DNA. Translation: ADM69426.1.
RefSeqiWP_013309599.1. NC_014483.1.
YP_003869964.1. NC_014483.1.

Genome annotation databases

EnsemblBacteriaiADM69426; ADM69426; PPE_01587.
GeneIDi9774340.
KEGGippy:PPE_01587.
PATRICi42408852. VBIPaePol94484_1569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000154 Genomic DNA. Translation: ADM69426.1 .
RefSeqi WP_013309599.1. NC_014483.1.
YP_003869964.1. NC_014483.1.

3D structure databases

ProteinModelPortali E0RD20.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADM69426 ; ADM69426 ; PPE_01587 .
GeneIDi 9774340.
KEGGi ppy:PPE_01587.
PATRICi 42408852. VBIPaePol94484_1569.

Phylogenomic databases

HOGENOMi HOG000021113.
KOi K00031.
OMAi IEFNERI.

Enzyme and pathway databases

BioCyci PPOL349520:GH6J-1581-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the polymyxin-producing plant-probiotic rhizobacterium Paenibacillus polymyxa E681."
    Kim J.F., Jeong H., Park S.Y., Kim S.B., Park Y.K., Choi S.K., Ryu C.M., Hur C.G., Ghim S.Y., Oh T.K., Kim J.J., Park C.S., Park S.H.
    J. Bacteriol. 192:6103-6104(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: E681Imported.

Entry informationi

Entry nameiE0RD20_PAEP6
AccessioniPrimary (citable) accession number: E0RD20
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: September 3, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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