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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Paenibacillus polymyxa (strain E681)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciPPOL349520:GH6J-1581-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:PPE_01587Imported
OrganismiPaenibacillus polymyxa (strain E681)Imported
Taxonomic identifieri349520 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
ProteomesiUP000002227 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi349520.PPE_01587.

Structurei

3D structure databases

ProteinModelPortaliE0RD20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0RD20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFVLYPFIS EEEKELMAKF EKFELPTEGE KITIDNGQLQ VPNHPVIPFI
60 70 80 90 100
EGDGTGRDIW KASKRVLDAA VEKAYNGSKK IAWYEVFAGE KAFNTYGEWL
110 120 130 140 150
PNDTLEAIRE YIVAIKGPLT TPIGGGIRSL NVALRQELDL YVCLRPVRYF
160 170 180 190 200
NGVPSPVKRP ELVDMVIFRE NTEDIYAGIE YAEGSEDVKK VIQFLQQELG
210 220 230 240 250
VNKIRFPETS GIGIKPVSSE GSKRLVRAAI QYAVDHGRKS VTLVHKGNIM
260 270 280 290 300
KFTEGAFKNW GYEVAEEEFA DKVFTWAQYD VIKEKDGEDA ANAAQKAAED
310 320 330 340 350
AGKIIIKDAI ADIALQQVLT RPSEFDVIAT LNLNGDYLSD ALAAQVGGIG
360 370 380 390 400
IAPGANINYV TGHAIFEATH GTAPKYADKD VVNPGSVILS GVMLLEHLGW
410 420 430 440
KEAADLIYKG LETSINKKIV TYDFARLMDG ATQVKCSEFA DTIISNL
Length:447
Mass (Da):49,310
Last modified:November 2, 2010 - v1
Checksum:i4D3678D937FB68A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000154 Genomic DNA. Translation: ADM69426.1.

Genome annotation databases

EnsemblBacteriaiADM69426; ADM69426; PPE_01587.
KEGGippy:PPE_01587.
PATRICi42408852. VBIPaePol94484_1569.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000154 Genomic DNA. Translation: ADM69426.1.

3D structure databases

ProteinModelPortaliE0RD20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi349520.PPE_01587.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADM69426; ADM69426; PPE_01587.
KEGGippy:PPE_01587.
PATRICi42408852. VBIPaePol94484_1569.

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiRDWGYEL.

Enzyme and pathway databases

BioCyciPPOL349520:GH6J-1581-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the polymyxin-producing plant-probiotic rhizobacterium Paenibacillus polymyxa E681."
    Kim J.F., Jeong H., Park S.Y., Kim S.B., Park Y.K., Choi S.K., Ryu C.M., Hur C.G., Ghim S.Y., Oh T.K., Kim J.J., Park C.S., Park S.H.
    J. Bacteriol. 192:6103-6104(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: E681Imported.

Entry informationi

Entry nameiE0RD20_PAEP6
AccessioniPrimary (citable) accession number: E0RD20
Entry historyi
Integrated into UniProtKB/TrEMBL: November 2, 2010
Last sequence update: November 2, 2010
Last modified: July 22, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.