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E0RD20

- E0RD20_PAEP6

UniProt

E0RD20 - E0RD20_PAEP6

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Paenibacillus polymyxa (strain E681)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 28 (01 Oct 2014)
      Sequence version 1 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciPPOL349520:GH6J-1581-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:PPE_01587Imported
    OrganismiPaenibacillus polymyxa (strain E681)Imported
    Taxonomic identifieri349520 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
    ProteomesiUP000002227: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliE0RD20.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.
    KOiK00031.
    OMAiIEFNERI.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E0RD20-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFVLYPFIS EEEKELMAKF EKFELPTEGE KITIDNGQLQ VPNHPVIPFI    50
    EGDGTGRDIW KASKRVLDAA VEKAYNGSKK IAWYEVFAGE KAFNTYGEWL 100
    PNDTLEAIRE YIVAIKGPLT TPIGGGIRSL NVALRQELDL YVCLRPVRYF 150
    NGVPSPVKRP ELVDMVIFRE NTEDIYAGIE YAEGSEDVKK VIQFLQQELG 200
    VNKIRFPETS GIGIKPVSSE GSKRLVRAAI QYAVDHGRKS VTLVHKGNIM 250
    KFTEGAFKNW GYEVAEEEFA DKVFTWAQYD VIKEKDGEDA ANAAQKAAED 300
    AGKIIIKDAI ADIALQQVLT RPSEFDVIAT LNLNGDYLSD ALAAQVGGIG 350
    IAPGANINYV TGHAIFEATH GTAPKYADKD VVNPGSVILS GVMLLEHLGW 400
    KEAADLIYKG LETSINKKIV TYDFARLMDG ATQVKCSEFA DTIISNL 447
    Length:447
    Mass (Da):49,310
    Last modified:November 2, 2010 - v1
    Checksum:i4D3678D937FB68A6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000154 Genomic DNA. Translation: ADM69426.1.
    RefSeqiWP_013309599.1. NC_014483.1.
    YP_003869964.1. NC_014483.1.

    Genome annotation databases

    EnsemblBacteriaiADM69426; ADM69426; PPE_01587.
    GeneIDi9774340.
    KEGGippy:PPE_01587.
    PATRICi42408852. VBIPaePol94484_1569.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000154 Genomic DNA. Translation: ADM69426.1 .
    RefSeqi WP_013309599.1. NC_014483.1.
    YP_003869964.1. NC_014483.1.

    3D structure databases

    ProteinModelPortali E0RD20.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADM69426 ; ADM69426 ; PPE_01587 .
    GeneIDi 9774340.
    KEGGi ppy:PPE_01587.
    PATRICi 42408852. VBIPaePol94484_1569.

    Phylogenomic databases

    HOGENOMi HOG000021113.
    KOi K00031.
    OMAi IEFNERI.

    Enzyme and pathway databases

    BioCyci PPOL349520:GH6J-1581-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of the polymyxin-producing plant-probiotic rhizobacterium Paenibacillus polymyxa E681."
      Kim J.F., Jeong H., Park S.Y., Kim S.B., Park Y.K., Choi S.K., Ryu C.M., Hur C.G., Ghim S.Y., Oh T.K., Kim J.J., Park C.S., Park S.H.
      J. Bacteriol. 192:6103-6104(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: E681Imported.

    Entry informationi

    Entry nameiE0RD20_PAEP6
    AccessioniPrimary (citable) accession number: E0RD20
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 2, 2010
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3