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E0CZA5

- E0CZA5_MOUSE

UniProt

E0CZA5 - E0CZA5_MOUSE

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Protein
Submitted name: Neurexin-1
Gene
Nrxn1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. acetylcholine receptor binding Source: MGI
  2. calcium channel regulator activity Source: MGI
  3. protein binding Source: MGI

GO - Biological processi

  1. neurotransmitter secretion Source: MGI
  2. positive regulation of synapse assembly Source: MGI
  3. positive regulation of synapse maturation Source: MGI
  4. regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
  5. synapse assembly Source: MGI
  6. synaptic transmission Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Neurexin-1Imported
Gene namesi
Name:Nrxn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1096391. Nrxn1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. presynaptic membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Proteomic databases

PRIDEiE0CZA5.

Expressioni

Gene expression databases

BgeeiE0CZA5.

Structurei

3D structure databases

ProteinModelPortaliE0CZA5.
SMRiE0CZA5. Positions 56-1300.

Family & Domainsi

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotations, Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117263.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PfamiPF02210. Laminin_G_2. 6 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0CZA5-1 [UniParc]FASTAAdd to Basket

« Hide

MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC     50
ESEMSFQLKT RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP 100
ATLLADTPVN DGAWHSVRIR RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF 150
SGLFVGGLPP ELRAAALKLT LASVREREPF KGWIRDVRVN SSQALPVDGG 200
EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ AVCDCSRTGF 250
RGKDCSQGKE EYIATFKGSE YFCYDLSQNP IQSSSDEITL SFKTLQRNGL 300
MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG KFNDNAWHDV 350
KVTRNLRQVT ISVDGILTTT GYTQEDYTML GSDDFFYVGG SPSTADLPGS 400
PVSNNFMGCL KEVVYKNNDV RLELSRLAKQ GDPKMKIHGV VAFKCENVAT 450
LDPITFETPE SFISLPKWNA KKTGSISFDF RTTEPNGLIL FSHGKPRHQK 500
DAKHPQMIKV DFFAIEMLDG HLYLLLDMGS GTIKIKALQK KVNDGEWYHV 550
DFQRDGRSGT ISVNTLRTPY TAPGESEILD LDDELYLGGL PENKAGLVFP 600
TEVWTALLNY GYVGCIRDLF IDGQSKDIRQ MAEIQSTAGV KPSCSKETAK 650
PCLSNPCKNN GMCRDGWNRY VCDCSGTGYL GRSCEREATV LSYDGSMFMK 700
IQLPVVMHTE AEDVSLRFRS QRAYGILMAT TSRDSADTLR LELDAGRVKL 750
TVNLDCIRIN CNSSKGPETL FAGYNLNDNE WHTVRVVRRG KSLKLTVDDQ 800
QAMTGQMAGD HTRLEFHNIE TGIITERRYL SSVPSNFIGH LQSLTFNGMA 850
YIDLCKNGDI DYCELNARFG FRNIIADPVT FKTKSSYVAL ATLQAYTSMH 900
LFFQFKTTSL DGLILYNSGD GNDFIVVELV KGYLHYVFDL GNGANLIKGS 950
SNKPLNDNQW HNVMISRDTS NLHTVKIDTK ITTQITAGAR NLDLKSDLYI 1000
GGVAKETYKS LPKLVHAKEG FQGCLASVDL NGRLPDLISD ALFCNGQIER 1050
GCEGPSTTCQ EDSCSNQGVC LQQWDGFSCD CSMTSFSGPL CNDPGTTYIF 1100
SKGGGQITYK WPPNDRPSTR ADRLAIGFST VQKEAVLVRV DSSSGLGDYL 1150
ELHIHQGKIG VKFNVGTDDI AIEESNAIIN DGKYHVVRFT RSGGNATLQV 1200
DSWPVIERYP AGNNDNERLA IARQRIPYRL GRVVDEWLLD KGRQLTIFNS 1250
QATIIIGGKE QGQPFQGQLS GLYYNGLKVL NMAAENDANI AIVGNVRLVG 1300
EVPSSMTTES TATAMQSEMS TSIMETTTTL ATSTARRGKP PTKEPISQTT 1350
DDILVASAEC PSDDEDIDPC EPSSANPTRV GGREPYPGSA EVIRESSSTT 1400
GMVVGIVAAA ALCILILLYA MYKYRNRDEG SYHVDESRNY ISNSAQSNGA 1450
VVKEKQPSSA KSANKNKKNK DKEYYV 1476
Length:1,476
Mass (Da):162,213
Last modified:October 5, 2010 - v1
Checksum:i560315D050AE313B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC101872 Genomic DNA. No translation available.
AC131326 Genomic DNA. No translation available.
AC151286 Genomic DNA. No translation available.
AC154325 Genomic DNA. No translation available.
AC154599 Genomic DNA. No translation available.
AC167814 Genomic DNA. No translation available.
AC170901 Genomic DNA. No translation available.
AC171209 Genomic DNA. No translation available.
CT025708 Genomic DNA. No translation available.
CT486002 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000159778; ENSMUSP00000125561; ENSMUSG00000024109.
UCSCiuc008dwc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC101872 Genomic DNA. No translation available.
AC131326 Genomic DNA. No translation available.
AC151286 Genomic DNA. No translation available.
AC154325 Genomic DNA. No translation available.
AC154599 Genomic DNA. No translation available.
AC167814 Genomic DNA. No translation available.
AC170901 Genomic DNA. No translation available.
AC171209 Genomic DNA. No translation available.
CT025708 Genomic DNA. No translation available.
CT486002 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E0CZA5.
SMRi E0CZA5. Positions 56-1300.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E0CZA5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000159778 ; ENSMUSP00000125561 ; ENSMUSG00000024109 .
UCSCi uc008dwc.1. mouse.

Organism-specific databases

MGIi MGI:1096391. Nrxn1.

Phylogenomic databases

GeneTreei ENSGT00750000117263.

Miscellaneous databases

ChiTaRSi NRXN1. mouse.
NextBioi 35553546.
SOURCEi Search...

Gene expression databases

Bgeei E0CZA5.

Family and domain databases

Gene3Di 2.60.120.200. 6 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view ]
Pfami PF02210. Laminin_G_2. 6 hits.
PF01034. Syndecan. 1 hit.
[Graphical view ]
SMARTi SM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 7 hits.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE0CZA5_MOUSE
AccessioniPrimary (citable) accession number: E0CZA5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: June 11, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi