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E0CZA5

- E0CZA5_MOUSE

UniProt

E0CZA5 - E0CZA5_MOUSE

Protein
Submitted name:

Neurexin-1

Gene

Nrxn1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. acetylcholine receptor binding Source: MGI
    2. calcium channel regulator activity Source: MGI
    3. protein binding Source: MGI

    GO - Biological processi

    1. neurotransmitter secretion Source: MGI
    2. positive regulation of synapse assembly Source: MGI
    3. positive regulation of synapse maturation Source: MGI
    4. regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
    5. synapse assembly Source: MGI
    6. synaptic transmission Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Neurexin-1Imported
    Gene namesi
    Name:Nrxn1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1096391. Nrxn1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. presynaptic membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Proteomic databases

    PRIDEiE0CZA5.

    Expressioni

    Gene expression databases

    BgeeiE0CZA5.

    Structurei

    3D structure databases

    ProteinModelPortaliE0CZA5.
    SMRiE0CZA5. Positions 56-1300.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    EGF-like domainUniRule annotationSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117263.

    Family and domain databases

    Gene3Di2.60.120.200. 6 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR001791. Laminin_G.
    IPR003585. Neurexin-like.
    IPR027789. Syndecan/Neurexin_dom.
    [Graphical view]
    PfamiPF02210. Laminin_G_2. 6 hits.
    PF01034. Syndecan. 1 hit.
    [Graphical view]
    SMARTiSM00294. 4.1m. 1 hit.
    SM00181. EGF. 3 hits.
    SM00282. LamG. 6 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 7 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
    PS50026. EGF_3. 3 hits.
    PS50025. LAM_G_DOMAIN. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E0CZA5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC     50
    ESEMSFQLKT RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP 100
    ATLLADTPVN DGAWHSVRIR RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF 150
    SGLFVGGLPP ELRAAALKLT LASVREREPF KGWIRDVRVN SSQALPVDGG 200
    EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ AVCDCSRTGF 250
    RGKDCSQGKE EYIATFKGSE YFCYDLSQNP IQSSSDEITL SFKTLQRNGL 300
    MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG KFNDNAWHDV 350
    KVTRNLRQVT ISVDGILTTT GYTQEDYTML GSDDFFYVGG SPSTADLPGS 400
    PVSNNFMGCL KEVVYKNNDV RLELSRLAKQ GDPKMKIHGV VAFKCENVAT 450
    LDPITFETPE SFISLPKWNA KKTGSISFDF RTTEPNGLIL FSHGKPRHQK 500
    DAKHPQMIKV DFFAIEMLDG HLYLLLDMGS GTIKIKALQK KVNDGEWYHV 550
    DFQRDGRSGT ISVNTLRTPY TAPGESEILD LDDELYLGGL PENKAGLVFP 600
    TEVWTALLNY GYVGCIRDLF IDGQSKDIRQ MAEIQSTAGV KPSCSKETAK 650
    PCLSNPCKNN GMCRDGWNRY VCDCSGTGYL GRSCEREATV LSYDGSMFMK 700
    IQLPVVMHTE AEDVSLRFRS QRAYGILMAT TSRDSADTLR LELDAGRVKL 750
    TVNLDCIRIN CNSSKGPETL FAGYNLNDNE WHTVRVVRRG KSLKLTVDDQ 800
    QAMTGQMAGD HTRLEFHNIE TGIITERRYL SSVPSNFIGH LQSLTFNGMA 850
    YIDLCKNGDI DYCELNARFG FRNIIADPVT FKTKSSYVAL ATLQAYTSMH 900
    LFFQFKTTSL DGLILYNSGD GNDFIVVELV KGYLHYVFDL GNGANLIKGS 950
    SNKPLNDNQW HNVMISRDTS NLHTVKIDTK ITTQITAGAR NLDLKSDLYI 1000
    GGVAKETYKS LPKLVHAKEG FQGCLASVDL NGRLPDLISD ALFCNGQIER 1050
    GCEGPSTTCQ EDSCSNQGVC LQQWDGFSCD CSMTSFSGPL CNDPGTTYIF 1100
    SKGGGQITYK WPPNDRPSTR ADRLAIGFST VQKEAVLVRV DSSSGLGDYL 1150
    ELHIHQGKIG VKFNVGTDDI AIEESNAIIN DGKYHVVRFT RSGGNATLQV 1200
    DSWPVIERYP AGNNDNERLA IARQRIPYRL GRVVDEWLLD KGRQLTIFNS 1250
    QATIIIGGKE QGQPFQGQLS GLYYNGLKVL NMAAENDANI AIVGNVRLVG 1300
    EVPSSMTTES TATAMQSEMS TSIMETTTTL ATSTARRGKP PTKEPISQTT 1350
    DDILVASAEC PSDDEDIDPC EPSSANPTRV GGREPYPGSA EVIRESSSTT 1400
    GMVVGIVAAA ALCILILLYA MYKYRNRDEG SYHVDESRNY ISNSAQSNGA 1450
    VVKEKQPSSA KSANKNKKNK DKEYYV 1476
    Length:1,476
    Mass (Da):162,213
    Last modified:October 5, 2010 - v1
    Checksum:i560315D050AE313B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC101872 Genomic DNA. No translation available.
    AC131326 Genomic DNA. No translation available.
    AC151286 Genomic DNA. No translation available.
    AC154325 Genomic DNA. No translation available.
    AC154599 Genomic DNA. No translation available.
    AC167814 Genomic DNA. No translation available.
    AC170901 Genomic DNA. No translation available.
    AC171209 Genomic DNA. No translation available.
    CT025708 Genomic DNA. No translation available.
    CT486002 Genomic DNA. No translation available.

    Genome annotation databases

    EnsembliENSMUST00000159778; ENSMUSP00000125561; ENSMUSG00000024109.
    UCSCiuc008dwc.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC101872 Genomic DNA. No translation available.
    AC131326 Genomic DNA. No translation available.
    AC151286 Genomic DNA. No translation available.
    AC154325 Genomic DNA. No translation available.
    AC154599 Genomic DNA. No translation available.
    AC167814 Genomic DNA. No translation available.
    AC170901 Genomic DNA. No translation available.
    AC171209 Genomic DNA. No translation available.
    CT025708 Genomic DNA. No translation available.
    CT486002 Genomic DNA. No translation available.

    3D structure databases

    ProteinModelPortali E0CZA5.
    SMRi E0CZA5. Positions 56-1300.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E0CZA5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000159778 ; ENSMUSP00000125561 ; ENSMUSG00000024109 .
    UCSCi uc008dwc.1. mouse.

    Organism-specific databases

    MGIi MGI:1096391. Nrxn1.

    Phylogenomic databases

    GeneTreei ENSGT00750000117263.

    Miscellaneous databases

    ChiTaRSi NRXN1. mouse.
    NextBioi 35553546.
    SOURCEi Search...

    Gene expression databases

    Bgeei E0CZA5.

    Family and domain databases

    Gene3Di 2.60.120.200. 6 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR001791. Laminin_G.
    IPR003585. Neurexin-like.
    IPR027789. Syndecan/Neurexin_dom.
    [Graphical view ]
    Pfami PF02210. Laminin_G_2. 6 hits.
    PF01034. Syndecan. 1 hit.
    [Graphical view ]
    SMARTi SM00294. 4.1m. 1 hit.
    SM00181. EGF. 3 hits.
    SM00282. LamG. 6 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 7 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
    PS50026. EGF_3. 3 hits.
    PS50025. LAM_G_DOMAIN. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE0CZA5_MOUSE
    AccessioniPrimary (citable) accession number: E0CZA5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3