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E0CZA5

- E0CZA5_MOUSE

UniProt

E0CZA5 - E0CZA5_MOUSE

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Protein
Submitted name:

Neurexin-1

Gene

Nrxn1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi

Functioni

GO - Molecular functioni

  1. acetylcholine receptor binding Source: MGI
  2. calcium channel regulator activity Source: MGI

GO - Biological processi

  1. neurotransmitter secretion Source: MGI
  2. positive regulation of synapse assembly Source: MGI
  3. positive regulation of synapse maturation Source: MGI
  4. regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
  5. synapse assembly Source: MGI
  6. synaptic transmission Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Neurexin-1Imported
Gene namesi
Name:Nrxn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1096391. Nrxn1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. presynaptic membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PRIDEiE0CZA5.

Expressioni

Gene expression databases

BgeeiE0CZA5.
ExpressionAtlasiE0CZA5. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliE0CZA5.
SMRiE0CZA5. Positions 56-1300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118991.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PfamiPF02210. Laminin_G_2. 6 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0CZA5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC
60 70 80 90 100
ESEMSFQLKT RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP
110 120 130 140 150
ATLLADTPVN DGAWHSVRIR RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF
160 170 180 190 200
SGLFVGGLPP ELRAAALKLT LASVREREPF KGWIRDVRVN SSQALPVDGG
210 220 230 240 250
EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ AVCDCSRTGF
260 270 280 290 300
RGKDCSQGKE EYIATFKGSE YFCYDLSQNP IQSSSDEITL SFKTLQRNGL
310 320 330 340 350
MLHTGKSADY VNLALKNGAV SLVINLGSGA FEALVEPVNG KFNDNAWHDV
360 370 380 390 400
KVTRNLRQVT ISVDGILTTT GYTQEDYTML GSDDFFYVGG SPSTADLPGS
410 420 430 440 450
PVSNNFMGCL KEVVYKNNDV RLELSRLAKQ GDPKMKIHGV VAFKCENVAT
460 470 480 490 500
LDPITFETPE SFISLPKWNA KKTGSISFDF RTTEPNGLIL FSHGKPRHQK
510 520 530 540 550
DAKHPQMIKV DFFAIEMLDG HLYLLLDMGS GTIKIKALQK KVNDGEWYHV
560 570 580 590 600
DFQRDGRSGT ISVNTLRTPY TAPGESEILD LDDELYLGGL PENKAGLVFP
610 620 630 640 650
TEVWTALLNY GYVGCIRDLF IDGQSKDIRQ MAEIQSTAGV KPSCSKETAK
660 670 680 690 700
PCLSNPCKNN GMCRDGWNRY VCDCSGTGYL GRSCEREATV LSYDGSMFMK
710 720 730 740 750
IQLPVVMHTE AEDVSLRFRS QRAYGILMAT TSRDSADTLR LELDAGRVKL
760 770 780 790 800
TVNLDCIRIN CNSSKGPETL FAGYNLNDNE WHTVRVVRRG KSLKLTVDDQ
810 820 830 840 850
QAMTGQMAGD HTRLEFHNIE TGIITERRYL SSVPSNFIGH LQSLTFNGMA
860 870 880 890 900
YIDLCKNGDI DYCELNARFG FRNIIADPVT FKTKSSYVAL ATLQAYTSMH
910 920 930 940 950
LFFQFKTTSL DGLILYNSGD GNDFIVVELV KGYLHYVFDL GNGANLIKGS
960 970 980 990 1000
SNKPLNDNQW HNVMISRDTS NLHTVKIDTK ITTQITAGAR NLDLKSDLYI
1010 1020 1030 1040 1050
GGVAKETYKS LPKLVHAKEG FQGCLASVDL NGRLPDLISD ALFCNGQIER
1060 1070 1080 1090 1100
GCEGPSTTCQ EDSCSNQGVC LQQWDGFSCD CSMTSFSGPL CNDPGTTYIF
1110 1120 1130 1140 1150
SKGGGQITYK WPPNDRPSTR ADRLAIGFST VQKEAVLVRV DSSSGLGDYL
1160 1170 1180 1190 1200
ELHIHQGKIG VKFNVGTDDI AIEESNAIIN DGKYHVVRFT RSGGNATLQV
1210 1220 1230 1240 1250
DSWPVIERYP AGNNDNERLA IARQRIPYRL GRVVDEWLLD KGRQLTIFNS
1260 1270 1280 1290 1300
QATIIIGGKE QGQPFQGQLS GLYYNGLKVL NMAAENDANI AIVGNVRLVG
1310 1320 1330 1340 1350
EVPSSMTTES TATAMQSEMS TSIMETTTTL ATSTARRGKP PTKEPISQTT
1360 1370 1380 1390 1400
DDILVASAEC PSDDEDIDPC EPSSANPTRV GGREPYPGSA EVIRESSSTT
1410 1420 1430 1440 1450
GMVVGIVAAA ALCILILLYA MYKYRNRDEG SYHVDESRNY ISNSAQSNGA
1460 1470
VVKEKQPSSA KSANKNKKNK DKEYYV
Length:1,476
Mass (Da):162,213
Last modified:October 5, 2010 - v1
Checksum:i560315D050AE313B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC101872 Genomic DNA. No translation available.
AC131326 Genomic DNA. No translation available.
AC151286 Genomic DNA. No translation available.
AC154325 Genomic DNA. No translation available.
AC154599 Genomic DNA. No translation available.
AC167814 Genomic DNA. No translation available.
AC170901 Genomic DNA. No translation available.
AC171209 Genomic DNA. No translation available.
CT025708 Genomic DNA. No translation available.
CT486002 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000159778; ENSMUSP00000125561; ENSMUSG00000024109.
UCSCiuc008dwc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC101872 Genomic DNA. No translation available.
AC131326 Genomic DNA. No translation available.
AC151286 Genomic DNA. No translation available.
AC154325 Genomic DNA. No translation available.
AC154599 Genomic DNA. No translation available.
AC167814 Genomic DNA. No translation available.
AC170901 Genomic DNA. No translation available.
AC171209 Genomic DNA. No translation available.
CT025708 Genomic DNA. No translation available.
CT486002 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E0CZA5.
SMRi E0CZA5. Positions 56-1300.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E0CZA5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000159778 ; ENSMUSP00000125561 ; ENSMUSG00000024109 .
UCSCi uc008dwc.1. mouse.

Organism-specific databases

MGIi MGI:1096391. Nrxn1.

Phylogenomic databases

GeneTreei ENSGT00760000118991.

Miscellaneous databases

ChiTaRSi Nrxn1. mouse.
NextBioi 35553546.
SOURCEi Search...

Gene expression databases

Bgeei E0CZA5.
ExpressionAtlasi E0CZA5. baseline and differential.

Family and domain databases

Gene3Di 2.60.120.200. 6 hits.
InterProi IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view ]
Pfami PF02210. Laminin_G_2. 6 hits.
PF01034. Syndecan. 1 hit.
[Graphical view ]
SMARTi SM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 7 hits.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE0CZA5_MOUSE
AccessioniPrimary (citable) accession number: E0CZA5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 26, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3