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E0CY11

- E0CY11_MOUSE

UniProt

E0CY11 - E0CY11_MOUSE

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Protein
Submitted name:

Neurexin-1

Gene
Nrxn1
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. acetylcholine receptor binding Source: MGI
  2. calcium channel regulator activity Source: MGI
  3. protein binding Source: MGI

GO - Biological processi

  1. neurotransmitter secretion Source: MGI
  2. positive regulation of synapse assembly Source: MGI
  3. positive regulation of synapse maturation Source: MGI
  4. regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
  5. synapse assembly Source: MGI
  6. synaptic transmission Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Neurexin-1Imported
Gene namesi
Name:Nrxn1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1096391. Nrxn1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. presynaptic membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Proteomic databases

PRIDEiE0CY11.

Expressioni

Gene expression databases

BgeeiE0CY11.

Structurei

3D structure databases

ProteinModelPortaliE0CY11.
SMRiE0CY11. Positions 56-1316.

Family & Domainsi

Keywords - Domaini

EGF-like domainUniRule annotationSAAS annotations, Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

GeneTreeiENSGT00750000117263.
KOiK07377.

Family and domain databases

Gene3Di2.60.120.200. 6 hits.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view]
PfamiPF02210. Laminin_G_2. 6 hits.
PF01034. Syndecan. 1 hit.
[Graphical view]
SMARTiSM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 7 hits.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0CY11-1 [UniParc]FASTAAdd to Basket

« Hide

MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC     50
ESEMSFQLKT RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP 100
ATLLADTPVN DGAWHSVRIR RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF 150
SGLFVGGLPP ELRAAALKLT LASVREREPF KGWIRDVRVN SSQALPVDGG 200
EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ AVCDCSRTGF 250
RGKDCSQEDN NVEGLAHLMM GDQGKEEYIA TFKGSEYFCY DLSQNPIQSS 300
SDEITLSFKT LQRNGLMLHT GKSADYVNLA LKNGAVSLVI NLGSGAFEAL 350
VEPVNGKFND NAWHDVKVTR NLRQVTISVD GILTTTGYTQ EDYTMLGSDD 400
FFYVGGSPST ADLPGSPVSN NFMGCLKEVV YKNNDVRLEL SRLAKQGDPK 450
MKIHGVVAFK CENVATLDPI TFETPESFIS LPKWNAKKTG SISFDFRTTE 500
PNGLILFSHG KPRHQKDAKH PQMIKVDFFA IEMLDGHLYL LLDMGSGTIK 550
IKALQKKVND GEWYHVDFQR DGRSGTISVN TLRTPYTAPG ESEILDLDDE 600
LYLGGLPENK AGLVFPTEVW TALLNYGYVG CIRDLFIDGQ SKDIRQMAEI 650
QSTAGVKPSC SKETAKPCLS NPCKNNGMCR DGWNRYVCDC SGTGYLGRSC 700
EREATVLSYD GSMFMKIQLP VVMHTEAEDV SLRFRSQRAY GILMATTSRD 750
SADTLRLELD AGRVKLTVNL DCIRINCNSS KGPETLFAGY NLNDNEWHTV 800
RVVRRGKSLK LTVDDQQAMT GQMAGDHTRL EFHNIETGII TERRYLSSVP 850
SNFIGHLQSL TFNGMAYIDL CKNGDIDYCE LNARFGFRNI IADPVTFKTK 900
SSYVALATLQ AYTSMHLFFQ FKTTSLDGLI LYNSGDGNDF IVVELVKGYL 950
HYVFDLGNGA NLIKGSSNKP LNDNQWHNVM ISRDTSNLHT VKIDTKITTQ 1000
ITAGARNLDL KSDLYIGGVA KETYKSLPKL VHAKEGFQGC LASVDLNGRL 1050
PDLISDALFC NGQIERGCEG PSTTCQEDSC SNQGVCLQQW DGFSCDCSMT 1100
SFSGPLCNDP GTTYIFSKGG GQITYKWPPN DRPSTRADRL AIGFSTVQKE 1150
AVLVRVDSSS GLGDYLELHI HQGKIGVKFN VGTDDIAIEE SNAIINDGKY 1200
HVVRFTRSGG NATLQVDSWP VIERYPAGNN DNERLAIARQ RIPYRLGRVV 1250
DEWLLDKGRQ LTIFNSQATI IIGGKEQGQP FQGQLSGLYY NGLKVLNMAA 1300
ENDANIAIVG NVRLVGEVPS SMTTESTATA MQSEMSTSIM ETTTTLATST 1350
ARRGKPPTKE PISQTTDDIL VASAECPSDD EDIDPCEPSS GGLANPTRVG 1400
GREPYPGSAE VIRESSSTTG MVVGIVAAAA LCILILLYAM YKYRNRDEGS 1450
YHVDESRNYI SNSAQSNGAV VKEKQPSSAK SANKNKKNKD KEYYV 1495
Length:1,495
Mass (Da):164,195
Last modified:November 16, 2011 - v2
Checksum:iBA712B37394A27F8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC101872 Genomic DNA. No translation available.
AC131326 Genomic DNA. No translation available.
AC151286 Genomic DNA. No translation available.
AC154325 Genomic DNA. No translation available.
AC154599 Genomic DNA. No translation available.
AC167814 Genomic DNA. No translation available.
AC170901 Genomic DNA. No translation available.
AC171209 Genomic DNA. No translation available.
CT025708 Genomic DNA. No translation available.
CT486002 Genomic DNA. No translation available.
RefSeqiNP_796258.2. NM_177284.2.
UniGeneiMm.491332.

Genome annotation databases

EnsembliENSMUST00000160800; ENSMUSP00000124561; ENSMUSG00000024109.
GeneIDi18189.
KEGGimmu:18189.
UCSCiuc012ayq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC101872 Genomic DNA. No translation available.
AC131326 Genomic DNA. No translation available.
AC151286 Genomic DNA. No translation available.
AC154325 Genomic DNA. No translation available.
AC154599 Genomic DNA. No translation available.
AC167814 Genomic DNA. No translation available.
AC170901 Genomic DNA. No translation available.
AC171209 Genomic DNA. No translation available.
CT025708 Genomic DNA. No translation available.
CT486002 Genomic DNA. No translation available.
RefSeqi NP_796258.2. NM_177284.2.
UniGenei Mm.491332.

3D structure databases

ProteinModelPortali E0CY11.
SMRi E0CY11. Positions 56-1316.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi E0CY11.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000160800 ; ENSMUSP00000124561 ; ENSMUSG00000024109 .
GeneIDi 18189.
KEGGi mmu:18189.
UCSCi uc012ayq.1. mouse.

Organism-specific databases

CTDi 9378.
MGIi MGI:1096391. Nrxn1.

Phylogenomic databases

GeneTreei ENSGT00750000117263.
KOi K07377.

Miscellaneous databases

ChiTaRSi NRXN1. mouse.
NextBioi 293528.
SOURCEi Search...

Gene expression databases

Bgeei E0CY11.

Family and domain databases

Gene3Di 2.60.120.200. 6 hits.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR000742. EG-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR001791. Laminin_G.
IPR003585. Neurexin-like.
IPR027789. Syndecan/Neurexin_dom.
[Graphical view ]
Pfami PF02210. Laminin_G_2. 6 hits.
PF01034. Syndecan. 1 hit.
[Graphical view ]
SMARTi SM00294. 4.1m. 1 hit.
SM00181. EGF. 3 hits.
SM00282. LamG. 6 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 7 hits.
PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
PS50026. EGF_3. 3 hits.
PS50025. LAM_G_DOMAIN. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE0CY11_MOUSE
AccessioniPrimary (citable) accession number: E0CY11
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: November 16, 2011
Last modified: June 11, 2014
This is version 39 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi