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E0CY11

- E0CY11_MOUSE

UniProt

E0CY11 - E0CY11_MOUSE

Protein
Submitted name:

Neurexin-1

Gene

Nrxn1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 3 out of 5- Protein predictedi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 2 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. acetylcholine receptor binding Source: MGI
    2. calcium channel regulator activity Source: MGI
    3. protein binding Source: MGI

    GO - Biological processi

    1. neurotransmitter secretion Source: MGI
    2. positive regulation of synapse assembly Source: MGI
    3. positive regulation of synapse maturation Source: MGI
    4. regulation of insulin secretion involved in cellular response to glucose stimulus Source: MGI
    5. synapse assembly Source: MGI
    6. synaptic transmission Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Neurexin-1Imported
    Gene namesi
    Name:Nrxn1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1096391. Nrxn1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. presynaptic membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Keywords - PTMi

    Disulfide bondSAAS annotation

    Proteomic databases

    PRIDEiE0CY11.

    Expressioni

    Gene expression databases

    BgeeiE0CY11.

    Structurei

    3D structure databases

    ProteinModelPortaliE0CY11.
    SMRiE0CY11. Positions 56-1316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    EGF-like domainUniRule annotationSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    GeneTreeiENSGT00750000117263.
    KOiK07377.

    Family and domain databases

    Gene3Di2.60.120.200. 6 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR001791. Laminin_G.
    IPR003585. Neurexin-like.
    IPR027789. Syndecan/Neurexin_dom.
    [Graphical view]
    PfamiPF02210. Laminin_G_2. 6 hits.
    PF01034. Syndecan. 1 hit.
    [Graphical view]
    SMARTiSM00294. 4.1m. 1 hit.
    SM00181. EGF. 3 hits.
    SM00282. LamG. 6 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 7 hits.
    PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
    PS50026. EGF_3. 3 hits.
    PS50025. LAM_G_DOMAIN. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    E0CY11-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTALVQRGG CCLLCLSLLL LGCWAELGSG LEFPGAEGQW TRFPKWNACC     50
    ESEMSFQLKT RSARGLVLYF DDEGFCDFLE LILTRGGRLQ LSFSIFCAEP 100
    ATLLADTPVN DGAWHSVRIR RQFRNTTLYI DRAEAKWVEV KSKRRDMTVF 150
    SGLFVGGLPP ELRAAALKLT LASVREREPF KGWIRDVRVN SSQALPVDGG 200
    EVKLDDEPPN SGGGSPCEAG EEGEGGVCLN GGVCSVVDDQ AVCDCSRTGF 250
    RGKDCSQEDN NVEGLAHLMM GDQGKEEYIA TFKGSEYFCY DLSQNPIQSS 300
    SDEITLSFKT LQRNGLMLHT GKSADYVNLA LKNGAVSLVI NLGSGAFEAL 350
    VEPVNGKFND NAWHDVKVTR NLRQVTISVD GILTTTGYTQ EDYTMLGSDD 400
    FFYVGGSPST ADLPGSPVSN NFMGCLKEVV YKNNDVRLEL SRLAKQGDPK 450
    MKIHGVVAFK CENVATLDPI TFETPESFIS LPKWNAKKTG SISFDFRTTE 500
    PNGLILFSHG KPRHQKDAKH PQMIKVDFFA IEMLDGHLYL LLDMGSGTIK 550
    IKALQKKVND GEWYHVDFQR DGRSGTISVN TLRTPYTAPG ESEILDLDDE 600
    LYLGGLPENK AGLVFPTEVW TALLNYGYVG CIRDLFIDGQ SKDIRQMAEI 650
    QSTAGVKPSC SKETAKPCLS NPCKNNGMCR DGWNRYVCDC SGTGYLGRSC 700
    EREATVLSYD GSMFMKIQLP VVMHTEAEDV SLRFRSQRAY GILMATTSRD 750
    SADTLRLELD AGRVKLTVNL DCIRINCNSS KGPETLFAGY NLNDNEWHTV 800
    RVVRRGKSLK LTVDDQQAMT GQMAGDHTRL EFHNIETGII TERRYLSSVP 850
    SNFIGHLQSL TFNGMAYIDL CKNGDIDYCE LNARFGFRNI IADPVTFKTK 900
    SSYVALATLQ AYTSMHLFFQ FKTTSLDGLI LYNSGDGNDF IVVELVKGYL 950
    HYVFDLGNGA NLIKGSSNKP LNDNQWHNVM ISRDTSNLHT VKIDTKITTQ 1000
    ITAGARNLDL KSDLYIGGVA KETYKSLPKL VHAKEGFQGC LASVDLNGRL 1050
    PDLISDALFC NGQIERGCEG PSTTCQEDSC SNQGVCLQQW DGFSCDCSMT 1100
    SFSGPLCNDP GTTYIFSKGG GQITYKWPPN DRPSTRADRL AIGFSTVQKE 1150
    AVLVRVDSSS GLGDYLELHI HQGKIGVKFN VGTDDIAIEE SNAIINDGKY 1200
    HVVRFTRSGG NATLQVDSWP VIERYPAGNN DNERLAIARQ RIPYRLGRVV 1250
    DEWLLDKGRQ LTIFNSQATI IIGGKEQGQP FQGQLSGLYY NGLKVLNMAA 1300
    ENDANIAIVG NVRLVGEVPS SMTTESTATA MQSEMSTSIM ETTTTLATST 1350
    ARRGKPPTKE PISQTTDDIL VASAECPSDD EDIDPCEPSS GGLANPTRVG 1400
    GREPYPGSAE VIRESSSTTG MVVGIVAAAA LCILILLYAM YKYRNRDEGS 1450
    YHVDESRNYI SNSAQSNGAV VKEKQPSSAK SANKNKKNKD KEYYV 1495
    Length:1,495
    Mass (Da):164,195
    Last modified:November 16, 2011 - v2
    Checksum:iBA712B37394A27F8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC101872 Genomic DNA. No translation available.
    AC131326 Genomic DNA. No translation available.
    AC151286 Genomic DNA. No translation available.
    AC154325 Genomic DNA. No translation available.
    AC154599 Genomic DNA. No translation available.
    AC167814 Genomic DNA. No translation available.
    AC170901 Genomic DNA. No translation available.
    AC171209 Genomic DNA. No translation available.
    CT025708 Genomic DNA. No translation available.
    CT486002 Genomic DNA. No translation available.
    RefSeqiNP_796258.2. NM_177284.2.
    UniGeneiMm.491332.

    Genome annotation databases

    EnsembliENSMUST00000160800; ENSMUSP00000124561; ENSMUSG00000024109.
    GeneIDi18189.
    KEGGimmu:18189.
    UCSCiuc012ayq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC101872 Genomic DNA. No translation available.
    AC131326 Genomic DNA. No translation available.
    AC151286 Genomic DNA. No translation available.
    AC154325 Genomic DNA. No translation available.
    AC154599 Genomic DNA. No translation available.
    AC167814 Genomic DNA. No translation available.
    AC170901 Genomic DNA. No translation available.
    AC171209 Genomic DNA. No translation available.
    CT025708 Genomic DNA. No translation available.
    CT486002 Genomic DNA. No translation available.
    RefSeqi NP_796258.2. NM_177284.2.
    UniGenei Mm.491332.

    3D structure databases

    ProteinModelPortali E0CY11.
    SMRi E0CY11. Positions 56-1316.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi E0CY11.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000160800 ; ENSMUSP00000124561 ; ENSMUSG00000024109 .
    GeneIDi 18189.
    KEGGi mmu:18189.
    UCSCi uc012ayq.1. mouse.

    Organism-specific databases

    CTDi 9378.
    MGIi MGI:1096391. Nrxn1.

    Phylogenomic databases

    GeneTreei ENSGT00750000117263.
    KOi K07377.

    Miscellaneous databases

    ChiTaRSi NRXN1. mouse.
    NextBioi 293528.
    SOURCEi Search...

    Gene expression databases

    Bgeei E0CY11.

    Family and domain databases

    Gene3Di 2.60.120.200. 6 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR001791. Laminin_G.
    IPR003585. Neurexin-like.
    IPR027789. Syndecan/Neurexin_dom.
    [Graphical view ]
    Pfami PF02210. Laminin_G_2. 6 hits.
    PF01034. Syndecan. 1 hit.
    [Graphical view ]
    SMARTi SM00294. 4.1m. 1 hit.
    SM00181. EGF. 3 hits.
    SM00282. LamG. 6 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 7 hits.
    PROSITEi PS00010. ASX_HYDROXYL. 1 hit.
    PS50026. EGF_3. 3 hits.
    PS50025. LAM_G_DOMAIN. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    2. Ensembl
      Submitted (MAY-2011) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiE0CY11_MOUSE
    AccessioniPrimary (citable) accession number: E0CY11
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 5, 2010
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 40 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3