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E0CXX7

- E0CXX7_MOUSE

UniProt

E0CXX7 - E0CXX7_MOUSE

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Protein
Submitted name: Insulin-2
Gene
Ins2
Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver By similarity.SAAS annotations

GO - Biological processi

  1. ER overload response Source: MGI
  2. activation of MAPK activity Source: MGI
  3. canonical Wnt signaling pathway Source: MGI
  4. glucose metabolic process Source: MGI
  5. glucose transport Source: MGI
  6. insulin receptor signaling pathway Source: MGI
  7. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: MGI
  8. lipid catabolic process Source: MGI
  9. myoblast fusion Source: MGI
  10. myotube differentiation Source: MGI
  11. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  12. positive regulation of phosphatidylinositol 3-kinase activity Source: MGI
  13. regulation of gene expression Source: MGI
  14. regulation of phosphorylation Source: MGI
  15. regulation of protein binding Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HormoneSAAS annotations

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-2Imported
Gene namesi
Name:Ins2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:96573. Ins2.

Subcellular locationi

Secreted By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular region Source: UniProtKB-SubCell
  3. nucleus Source: MGI
  4. secretory granule Source: MGI
  5. small nucleolar ribonucleoprotein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotations

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Expressioni

Gene expression databases

ArrayExpressiE0CXX7.
BgeeiE0CXX7.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds By similarity.SAAS annotations

Structurei

3D structure databases

ProteinModelPortaliE0CXX7.
SMRiE0CXX7. Positions 25-98.

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000015440.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0CXX7-1 [UniParc]FASTAAdd to Basket

« Hide

MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY   50
TPMSRREVED PQGDLQTLAL EVAQQKRGIV DQCCTSICSL YQLENYCN 98
Length:98
Mass (Da):11,314
Last modified:October 5, 2010 - v1
Checksum:iE06380BEA677EA90
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC013548 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000162317; ENSMUSP00000124643; ENSMUSG00000000215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC013548 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E0CXX7.
SMRi E0CXX7. Positions 25-98.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000162317 ; ENSMUSP00000124643 ; ENSMUSG00000000215 .

Organism-specific databases

MGIi MGI:96573. Ins2.

Phylogenomic databases

GeneTreei ENSGT00390000015440.

Miscellaneous databases

ChiTaRSi Ins2. mouse.
NextBioi 35553121.
SOURCEi Search...

Gene expression databases

ArrayExpressi E0CXX7.
Bgeei E0CXX7.

Family and domain databases

Gene3Di 1.10.100.10. 1 hit.
InterProi IPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF00049. Insulin. 1 hit.
[Graphical view ]
PRINTSi PR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE0CXX7_MOUSE
AccessioniPrimary (citable) accession number: E0CXX7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteome

External Data

Dasty 3

Similar proteinsi