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E0CXX7 (E0CXX7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length98 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver By similarity. SAAS SAAS004825

Subunit structure

Heterodimer of a B chain and an A chain linked by two disulfide bonds By similarity. SAAS SAAS004825

Subcellular location

Secreted By similarity RuleBase RU000406 SAAS SAAS004825.

Sequence similarities

Belongs to the insulin family. RuleBase RU000406

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. Ensembl ENSMUSP00000124643

Ontologies

Keywords
   Biological processCarbohydrate metabolism
Glucose metabolism SAAS SAAS004825
   Cellular componentSecreted SAAS SAAS004825
   Molecular functionHormone SAAS SAAS004825
   PTMDisulfide bond SAAS SAAS004825
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processER overload response

Inferred from mutant phenotype PubMed 11854325. Source: MGI

activation of MAPK activity

Inferred from direct assay PubMed 12059784. Source: MGI

canonical Wnt signaling pathway

Inferred from genetic interaction PubMed 15282335. Source: MGI

glucose metabolic process

Inferred from mutant phenotype PubMed 11854325. Source: MGI

glucose transport

Traceable author statement PubMed 12297296. Source: MGI

insulin receptor signaling pathway

Inferred from direct assay PubMed 12805218. Source: MGI

intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Inferred from mutant phenotype PubMed 11854325. Source: MGI

lipid catabolic process

Inferred from direct assay PubMed 12805218. Source: MGI

myoblast fusion

Inferred from genetic interaction PubMed 15282335. Source: MGI

myotube differentiation

Inferred from genetic interaction PubMed 15282335. Source: MGI

negative regulation of transcription from RNA polymerase II promoter

Inferred from direct assay PubMed 9689059. Source: MGI

positive regulation of phosphatidylinositol 3-kinase activity

Inferred from direct assay PubMed 11375348. Source: MGI

regulation of gene expression

Inferred from direct assay PubMed 19293336. Source: MGI

regulation of phosphorylation

Inferred from direct assay PubMed 12059784. Source: MGI

regulation of protein binding

Inferred from direct assay PubMed 9507006. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15793245. Source: MGI

extracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from direct assay PubMed 12488434. Source: MGI

secretory granule

Inferred from direct assay PubMed 15788565. Source: MGI

small nucleolar ribonucleoprotein complex

Inferred from direct assay PubMed 12488434. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
E0CXX7 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: E06380BEA677EA90

FASTA9811,314
        10         20         30         40         50         60 
MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY TPMSRREVED 

        70         80         90 
PQGDLQTLAL EVAQQKRGIV DQCCTSICSL YQLENYCN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC013548 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortalE0CXX7.
SMRE0CXX7. Positions 25-98.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000162317; ENSMUSP00000124643; ENSMUSG00000000215.

Organism-specific databases

MGIMGI:96573. Ins2.

Phylogenomic databases

GeneTreeENSGT00390000015440.

Gene expression databases

ArrayExpressE0CXX7.
BgeeE0CXX7.

Family and domain databases

Gene3D1.10.100.10. 1 hit.
InterProIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMSSF56994. SSF56994. 1 hit.
PROSITEPS00262. INSULIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSIns2. mouse.
NextBio35553121.
SOURCESearch...

Entry information

Entry nameE0CXX7_MOUSE
AccessionPrimary (citable) accession number: E0CXX7
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)