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Protein

Insulin

Gene

Ins2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormoneUniRule annotationSAAS annotation
Biological processCarbohydrate metabolism, Glucose metabolismUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
InsulinUniRule annotation
Gene namesi
Name:Ins2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:96573. Ins2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedUniRule annotationSAAS annotation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_500313327725 – 98InsulinSequence analysisAdd BLAST74

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000000215.
ExpressionAtlasiE0CXX7. baseline and differential.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.UniRule annotationSAAS annotation

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliE0CXX7.
SMRiE0CXX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 97IlGFInterPro annotationAdd BLAST70

Sequence similaritiesi

Belongs to the insulin family.UniRule annotationSAAS annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

GeneTreeiENSGT00390000015440.

Family and domain databases

InterProiView protein in InterPro
IPR004825. Insulin.
IPR016179. Insulin-like.
IPR036438. Insulin-like_sf.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
PfamiView protein in Pfam
PF00049. Insulin. 1 hit.
PRINTSiPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTiView protein in SMART
SM00078. IlGF. 1 hit.
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiView protein in PROSITE
PS00262. INSULIN. 1 hit.

Sequencei

Sequence statusi: Complete.

E0CXX7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY
60 70 80 90
TPMSRREVED PQGDLQTLAL EVAQQKRGIV DQCCTSICSL YQLENYCN
Length:98
Mass (Da):11,314
Last modified:October 5, 2010 - v1
Checksum:iE06380BEA677EA90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012382 Genomic DNA. No translation available.
AC013548 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000162317; ENSMUSP00000124643; ENSMUSG00000000215.

Similar proteinsi

Entry informationi

Entry nameiE0CXX7_MOUSE
AccessioniPrimary (citable) accession number: E0CXX7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported