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E0CXX7

- E0CXX7_MOUSE

UniProt

E0CXX7 - E0CXX7_MOUSE

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Protein
Submitted name:

Insulin-2

Gene

Ins2

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Protein inferred from homologyi

Functioni

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.SAAS annotation

GO - Biological processi

  1. activation of MAPK activity Source: MGI
  2. canonical Wnt signaling pathway Source: MGI
  3. ER overload response Source: MGI
  4. glucose metabolic process Source: MGI
  5. glucose transport Source: MGI
  6. insulin receptor signaling pathway Source: MGI
  7. intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Source: MGI
  8. lipid catabolic process Source: MGI
  9. myoblast fusion Source: MGI
  10. myotube differentiation Source: MGI
  11. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  12. positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
  13. positive regulation of phosphatidylinositol 3-kinase activity Source: MGI
  14. regulation of gene expression Source: MGI
  15. regulation of phosphorylation Source: MGI
  16. regulation of protein binding Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

HormoneSAAS annotation

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolismSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Insulin-2Imported
Gene namesi
Name:Ins2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:96573. Ins2.

Subcellular locationi

Secreted UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. extracellular region Source: UniProtKB-SubCell
  3. nucleus Source: MGI
  4. secretory granule Source: MGI
  5. small nucleolar ribonucleoprotein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiE0CXX7.
ExpressionAtlasiE0CXX7. baseline and differential.

Interactioni

Subunit structurei

Heterodimer of a B chain and an A chain linked by two disulfide bonds.SAAS annotation

Structurei

3D structure databases

ProteinModelPortaliE0CXX7.
SMRiE0CXX7. Positions 25-98.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the insulin family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000015440.

Family and domain databases

Gene3Di1.10.100.10. 1 hit.
InterProiIPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view]
PfamiPF00049. Insulin. 1 hit.
[Graphical view]
PRINTSiPR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTiSM00078. IlGF. 1 hit.
[Graphical view]
SUPFAMiSSF56994. SSF56994. 1 hit.
PROSITEiPS00262. INSULIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

E0CXX7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALWMRFLPL LALLFLWESH PTQAFVKQHL CGSHLVEALY LVCGERGFFY
60 70 80 90
TPMSRREVED PQGDLQTLAL EVAQQKRGIV DQCCTSICSL YQLENYCN
Length:98
Mass (Da):11,314
Last modified:October 5, 2010 - v1
Checksum:iE06380BEA677EA90
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013548 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENSMUST00000162317; ENSMUSP00000124643; ENSMUSG00000000215.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013548 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortali E0CXX7.
SMRi E0CXX7. Positions 25-98.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000162317 ; ENSMUSP00000124643 ; ENSMUSG00000000215 .

Organism-specific databases

MGIi MGI:96573. Ins2.

Phylogenomic databases

GeneTreei ENSGT00390000015440.

Miscellaneous databases

ChiTaRSi Ins2. mouse.
NextBioi 35553121.
SOURCEi Search...

Gene expression databases

Bgeei E0CXX7.
ExpressionAtlasi E0CXX7. baseline and differential.

Family and domain databases

Gene3Di 1.10.100.10. 1 hit.
InterProi IPR004825. Insulin.
IPR016179. Insulin-like.
IPR022353. Insulin_CS.
IPR022352. Insulin_family.
[Graphical view ]
Pfami PF00049. Insulin. 1 hit.
[Graphical view ]
PRINTSi PR00277. INSULIN.
PR00276. INSULINFAMLY.
SMARTi SM00078. IlGF. 1 hit.
[Graphical view ]
SUPFAMi SSF56994. SSF56994. 1 hit.
PROSITEi PS00262. INSULIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  2. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiE0CXX7_MOUSE
AccessioniPrimary (citable) accession number: E0CXX7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 26, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3