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Protein

Proteasome endopeptidase complex

Gene

Psma6

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Cleavage of peptide bonds with very broad specificity.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Threonine proteasePROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Proteasome endopeptidase complexPROSITE-ProRule annotation (EC:3.4.25.1PROSITE-ProRule annotation)
Gene namesi
Name:Psma6Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:1347006. Psma6.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmPROSITE-ProRule annotation, ProteasomePROSITE-ProRule annotation

PTM / Processingi

Proteomic databases

MaxQBiE0CXB1.
PaxDbiE0CXB1.
PeptideAtlasiE0CXB1.
PRIDEiE0CXB1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000021024.
ExpressionAtlasiE0CXB1. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021412.

Structurei

3D structure databases

ProteinModelPortaliE0CXB1.
SMRiE0CXB1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase T1A family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0182. Eukaryota.
ENOG410XR7X. LUCA.
GeneTreeiENSGT00550000074807.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR001353. Proteasome_sua/b.
IPR034642. Proteasome_subunit_alpha6.
PANTHERiPTHR11599:SF98. PTHR11599:SF98. 1 hit.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS51475. PROTEASOME_ALPHA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

E0CXB1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLRKKYAF KAINQGGLTS VAVRGKDCAV IVTQKKVPDK LLDSSTVTHL
60 70 80 90 100
FKITESIGCV MTGMTADSRS QVQRARYEAA NWKYKYGYEI PVDMLCKRIA
110 120 130 140 150
DISQVYTQNA EMRPLGCCMI LIGIDEEQGP QVYKCDPAGY YCGFKATAAG
160 170 180 190 200
VKQTESTSFL EKKVKKKFDW TFEQTVETAI TCLSTVLSID FKPSEIEVGV
210 220
VTVENPKFRI LTEAEIDAHL VALAERD
Length:227
Mass (Da):25,264
Last modified:October 5, 2010 - v1
Checksum:iED770AE759A8172F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159636 Genomic DNA. No translation available.
RefSeqiNP_001297512.1. NM_001310583.1.
UniGeneiMm.30210.

Genome annotation databases

EnsembliENSMUST00000163070; ENSMUSP00000124781; ENSMUSG00000021024.
GeneIDi26443.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC159636 Genomic DNA. No translation available.
RefSeqiNP_001297512.1. NM_001310583.1.
UniGeneiMm.30210.

3D structure databases

ProteinModelPortaliE0CXB1.
SMRiE0CXB1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021412.

Proteomic databases

MaxQBiE0CXB1.
PaxDbiE0CXB1.
PeptideAtlasiE0CXB1.
PRIDEiE0CXB1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000163070; ENSMUSP00000124781; ENSMUSG00000021024.
GeneIDi26443.

Organism-specific databases

CTDi5687.
MGIiMGI:1347006. Psma6.

Phylogenomic databases

eggNOGiKOG0182. Eukaryota.
ENOG410XR7X. LUCA.
GeneTreeiENSGT00550000074807.

Miscellaneous databases

ChiTaRSiPsma6. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021024.
ExpressionAtlasiE0CXB1. baseline and differential.

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiView protein in InterPro
IPR029055. Ntn_hydrolases_N.
IPR023332. Proteasome_alpha-type.
IPR001353. Proteasome_sua/b.
IPR034642. Proteasome_subunit_alpha6.
PANTHERiPTHR11599:SF98. PTHR11599:SF98. 1 hit.
PfamiView protein in Pfam
PF00227. Proteasome. 1 hit.
SUPFAMiSSF56235. SSF56235. 1 hit.
PROSITEiView protein in PROSITE
PS51475. PROTEASOME_ALPHA_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiE0CXB1_MOUSE
AccessioniPrimary (citable) accession number: E0CXB1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: June 7, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.