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Protein
Submitted name:

Vitronectin

Gene

VTN

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
VitronectinImported
Gene namesi
Name:VTNImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Organism-specific databases

EuPathDBiHostDB:ENSG00000109072.13.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_500313300220 – 478Sequence analysisAdd BLAST459

Keywords - PTMi

Disulfide bondSAAS annotation

Proteomic databases

PaxDbiD9ZGG2.
PRIDEiD9ZGG2.

Expressioni

Gene expression databases

BgeeiENSG00000109072.
ExpressionAtlasiD9ZGG2. baseline and differential.
GenevisibleiD9ZGG2. HS.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliD9ZGG2.
SMRiD9ZGG2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 63SMBInterPro annotationAdd BLAST44
Repeati158 – 202HemopexinPROSITE-ProRule annotationAdd BLAST45
Repeati203 – 250HemopexinPROSITE-ProRule annotationAdd BLAST48
Repeati251 – 305HemopexinPROSITE-ProRule annotationAdd BLAST55
Repeati419 – 472HemopexinPROSITE-ProRule annotationAdd BLAST54

Keywords - Domaini

RepeatSAAS annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG1565. Eukaryota.
ENOG410XQ5D. LUCA.
KOiK06251.
OMAiQPSQEEC.
OrthoDBiEOG091G0817.
PhylomeDBiD9ZGG2.

Family and domain databases

CDDicd00094. HX. 1 hit.
Gene3Di2.110.10.10. 2 hits.
InterProiView protein in InterPro
IPR000585. Hemopexin-like_dom.
IPR036375. Hemopexin-like_dom_sf.
IPR018487. Hemopexin-like_repeat.
IPR018486. Hemopexin_CS.
IPR036024. Somatomedin_B-like_dom_sf.
IPR020436. Somatomedin_B_chordata.
IPR001212. Somatomedin_B_dom.
PfamiView protein in Pfam
PF00045. Hemopexin. 4 hits.
PF01033. Somatomedin_B. 1 hit.
PRINTSiPR00022. SOMATOMEDINB.
SMARTiView protein in SMART
SM00120. HX. 4 hits.
SM00201. SO. 1 hit.
SUPFAMiSSF50923. SSF50923. 3 hits.
SSF90188. SSF90188. 1 hit.
PROSITEiView protein in PROSITE
PS00024. HEMOPEXIN. 2 hits.
PS51642. HEMOPEXIN_2. 4 hits.
PS00524. SMB_1. 1 hit.
PS50958. SMB_2. 1 hit.

Sequencei

Sequence statusi: Complete.

D9ZGG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPLRPLLIL ALLAWVALAD QESCKGRCTE GFNVDKKCQC DELCSYYQSC
60 70 80 90 100
CTDYTAECKP QVTRGDVFTM PEDEYTVYDD GEEKNNATVH EQVGGPSLTS
110 120 130 140 150
DLQAQSKGNP EQTPVLKPEE EAPAPEVGAS KPEGIDSRPE TLHPGRPQPP
160 170 180 190 200
AEEELCSGKP FDAFTDLKNG SLFAFRGQYC YELDEKAVRP GYPKLIRDVW
210 220 230 240 250
GIEGPIDAAF TRINCQGKTY LFKGSQYWRF EDGVLDPDYP RNISDGFDGI
260 270 280 290 300
PDNVDAALAL PAHSYSGRER VYFFKGKQYW EYQFQHQPSQ EECEGSSLSA
310 320 330 340 350
VFEHFAMMQR DSWEDIFELL FWGRTSAGTR QPQFISRDWH GVPGQVDAAM
360 370 380 390 400
AGRIYISGMA PRPSLAKKQR FRHRNRKGYR SQRGHSRGRN QNSRRPSRAT
410 420 430 440 450
WLSLFSSEES NLGANNYDDY RMDWLVPATC EPIQSVFFFS GDKYYRVNLR
460 470
TRRVDTVDPP YPRSIAQYWL GCPAPGHL
Length:478
Mass (Da):54,306
Last modified:October 5, 2010 - v1
Checksum:i0D6DB5591CBFEF45
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM015600 Genomic DNA. Translation: ADL14521.1.
RefSeqiNP_000629.3. NM_000638.3.
UniGeneiHs.2257.

Genome annotation databases

GeneIDi7448.
KEGGihsa:7448.

Similar proteinsi

Entry informationi

Entry nameiD9ZGG2_HUMAN
AccessioniPrimary (citable) accession number: D9ZGG2
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 22, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.