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D9ZGG0

- D9ZGG0_HUMAN

UniProt

D9ZGG0 - D9ZGG0_HUMAN

Protein
Submitted name:

T-box 1

Gene

TBX1

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: Ensembl
    2. anterior/posterior pattern specification Source: Ensembl
    3. aorta morphogenesis Source: Ensembl
    4. blood vessel remodeling Source: Ensembl
    5. cell fate specification Source: Ensembl
    6. cell proliferation Source: Ensembl
    7. cochlea morphogenesis Source: Ensembl
    8. coronary artery morphogenesis Source: Ensembl
    9. determination of left/right symmetry Source: Ensembl
    10. embryonic cranial skeleton morphogenesis Source: Ensembl
    11. enamel mineralization Source: Ensembl
    12. epithelial cell differentiation Source: Ensembl
    13. face morphogenesis Source: Ensembl
    14. lymph vessel development Source: Ensembl
    15. mesoderm development Source: Ensembl
    16. middle ear morphogenesis Source: Ensembl
    17. muscle cell fate commitment Source: Ensembl
    18. muscle tissue morphogenesis Source: Ensembl
    19. negative regulation of cell differentiation Source: Ensembl
    20. neural crest cell migration Source: Ensembl
    21. otic vesicle morphogenesis Source: Ensembl
    22. outer ear morphogenesis Source: Ensembl
    23. outflow tract morphogenesis Source: Ensembl
    24. pharyngeal system development Source: Ensembl
    25. positive regulation of epithelial cell proliferation Source: Ensembl
    26. positive regulation of secondary heart field cardioblast proliferation Source: Ensembl
    27. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    28. semicircular canal morphogenesis Source: Ensembl
    29. sensory perception of sound Source: Ensembl
    30. social behavior Source: Ensembl
    31. thymus development Source: Ensembl
    32. thyroid gland development Source: Ensembl
    33. transcription, DNA-templated Source: UniProtKB-KW
    34. vagus nerve morphogenesis Source: Ensembl

    Keywords - Biological processi

    Transcription, Transcription regulationSAAS annotation

    Keywords - Ligandi

    DNA-bindingSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    T-box 1Imported
    Gene namesi
    Name:TBX1Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    Nucleus SAAS annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusSAAS annotation

    PTM / Processingi

    Proteomic databases

    PRIDEiD9ZGG0.

    Expressioni

    Gene expression databases

    ArrayExpressiD9ZGG0.
    BgeeiD9ZGG0.

    Structurei

    3D structure databases

    ProteinModelPortaliD9ZGG0.
    SMRiD9ZGG0. Positions 109-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains T-box DNA-binding domain.SAAS annotation

    Phylogenomic databases

    KOiK10175.
    OMAiANMYSAT.
    PhylomeDBiD9ZGG0.

    Family and domain databases

    Gene3Di2.60.40.820. 1 hit.
    InterProiIPR008967. p53-like_TF_DNA-bd.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view]
    PANTHERiPTHR11267. PTHR11267. 1 hit.
    PfamiPF00907. T-box. 1 hit.
    [Graphical view]
    PRINTSiPR00937. TBOX.
    SMARTiSM00425. TBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49417. SSF49417. 1 hit.
    PROSITEiPS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D9ZGG0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHFSTVTRDM EAFTASSLSS LGAAGGFPGA ASPGADPYGP REPPPPPPRY    50
    DPCAAAAPGA PGPPPPPHAY PFAPAAGAAT SAAAEPEGPG ASCAAAAKAP 100
    VKKNAKVAGV SVQLEMKALW DEFNQLGTEM IVTKAGRRMF PTFQVKLFGM 150
    DPMADYMLLM DFVPVDDKRY RYAFHSSSWL VAGKADPATP GRVHYHPDSP 200
    AKGAQWMKQI VSFDKLKLTN NLLDDNGHII LNSMHRYQPR FHVVYVDPRK 250
    DSEKYAEENF KTFVFEETRF TAVTAYQNHR ITQLKIASNP FAKGFRDCDP 300
    EDWPRNHRPG ALPLMSAFAR SRNPVASPTQ PSGTEKDAAE ARREFQRDAG 350
    GPAVLGDPAH PPQLLARVLS PSLPGAGGAG GLVPLPGAPG GRPSPPNPEL 400
    RLEAPGASEP LHHHPYKYPA AAYDHYLGAK SRPAPYPLPG LRGHGYHPHA 450
    HPHHHHHPVS PAAAAAAAAA AAAAAANMYS SAGAAPPGSY DYCPR 495
    Length:495
    Mass (Da):52,666
    Last modified:October 5, 2010 - v1
    Checksum:iFB0C150FEA6155FC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM015598 Genomic DNA. Translation: ADL14519.1.
    RefSeqiNP_542378.1. NM_080647.1.
    XP_006724375.1. XM_006724312.1.
    UniGeneiHs.173984.

    Genome annotation databases

    GeneIDi6899.
    KEGGihsa:6899.
    UCSCiuc002zqa.1. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM015598 Genomic DNA. Translation: ADL14519.1 .
    RefSeqi NP_542378.1. NM_080647.1.
    XP_006724375.1. XM_006724312.1.
    UniGenei Hs.173984.

    3D structure databases

    ProteinModelPortali D9ZGG0.
    SMRi D9ZGG0. Positions 109-296.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi D9ZGG0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6899.
    KEGGi hsa:6899.
    UCSCi uc002zqa.1. human.

    Organism-specific databases

    CTDi 6899.

    Phylogenomic databases

    KOi K10175.
    OMAi ANMYSAT.
    PhylomeDBi D9ZGG0.

    Miscellaneous databases

    GenomeRNAii 6899.
    NextBioi 26967.

    Gene expression databases

    ArrayExpressi D9ZGG0.
    Bgeei D9ZGG0.

    Family and domain databases

    Gene3Di 2.60.40.820. 1 hit.
    InterProi IPR008967. p53-like_TF_DNA-bd.
    IPR001699. TF_T-box.
    IPR018186. TF_T-box_CS.
    [Graphical view ]
    PANTHERi PTHR11267. PTHR11267. 1 hit.
    Pfami PF00907. T-box. 1 hit.
    [Graphical view ]
    PRINTSi PR00937. TBOX.
    SMARTi SM00425. TBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49417. SSF49417. 1 hit.
    PROSITEi PS01283. TBOX_1. 1 hit.
    PS01264. TBOX_2. 1 hit.
    PS50252. TBOX_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiD9ZGG0_HUMAN
    AccessioniPrimary (citable) accession number: D9ZGG0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.