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Protein
Submitted name:

Collagen, type VI, alpha 3

Gene

COL6A3

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Collagen, type VI, alpha 3Imported
Gene namesi
Name:COL6A3Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

  • Secretedextracellular space SAAS annotation

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence analysisAdd
BLAST
Chaini26 – 31773152Sequence analysisPRO_5003133001Add
BLAST

Proteomic databases

PaxDbiD9ZGF2.
PRIDEiD9ZGF2.

Expressioni

Gene expression databases

BgeeiENSG00000163359.
ExpressionAtlasiD9ZGF2. baseline and differential.
GenevisibleiD9ZGF2. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000295550.

Structurei

3D structure databases

ProteinModelPortaliD9ZGF2.
SMRiD9ZGF2. Positions 1027-1222, 3108-3165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 213175VWFAInterPro annotationAdd
BLAST
Domaini242 – 419178VWFAInterPro annotationAdd
BLAST
Domaini445 – 620176VWFAInterPro annotationAdd
BLAST
Domaini639 – 816178VWFAInterPro annotationAdd
BLAST
Domaini837 – 1009173VWFAInterPro annotationAdd
BLAST
Domaini1029 – 1205177VWFAInterPro annotationAdd
BLAST
Domaini1233 – 1404172VWFAInterPro annotationAdd
BLAST
Domaini1436 – 1609174VWFAInterPro annotationAdd
BLAST
Domaini1639 – 1812174VWFAInterPro annotationAdd
BLAST
Domaini1838 – 2024187VWFAInterPro annotationAdd
BLAST
Domaini2402 – 2581180VWFAInterPro annotationAdd
BLAST
Domaini2619 – 2815197VWFAInterPro annotationAdd
BLAST
Domaini2991 – 308595Fibronectin type-IIIInterPro annotationAdd
BLAST
Domaini3112 – 316251BPTI/Kunitz inhibitorInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BPTI/Kunitz inhibitor domain.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3544. Eukaryota.
ENOG41103QR. LUCA.
KOiK06238.
OMAiSWRPSFR.
OrthoDBiEOG091G14M8.
PhylomeDBiD9ZGF2.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.40.50.410. 12 hits.
4.10.410.10. 1 hit.
InterProiIPR008160. Collagen.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
PF00092. VWA. 12 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 1 hit.
SM00327. VWA. 12 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF53300. SSF53300. 12 hits.
SSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50853. FN3. 1 hit.
PS50234. VWFA. 12 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D9ZGF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRKHRHLPLV AVFCLFLSGF PTTHAQQQQA DVKNGAAADI IFLVDSSWTI
60 70 80 90 100
GEEHFQLVRE FLYDVVKSLA VGENDFHFAL VQFNGNPHTE FLLNTYRTKQ
110 120 130 140 150
EVLSHISNMS YIGGTNQTGK GLEYIMQSHL TKAAGSRAGD GVPQVIVVLT
160 170 180 190 200
DGHSKDGLAL PSAELKSADV NVFAIGVEDA DEGALKEIAS EPLNMHMFNL
210 220 230 240 250
ENFTSLHDIV GNLVSCVHSS VSPERAGDTE TLKDITAQDS ADIIFLIDGS
260 270 280 290 300
NNTGSVNFAV ILDFLVNLLE KLPIGTQQIR VGVVQFSDEP RTMFSLDTYS
310 320 330 340 350
TKAQVLGAVK ALGFAGGELA NIGLALDFVV ENHFTRAGGS RVEEGVPQVL
360 370 380 390 400
VLISAGPSSD EIRYGVVALK QASVFSFGLG AQAASRAELQ HIATDDNLVF
410 420 430 440 450
TVPEFRSFGD LQEKLLPYIV GVAQRHIVLK PPTIVTQVIE VNKRDIVFLV
460 470 480 490 500
DGSSALGLAN FNAIRDFIAK VIQRLEIGQD LIQVAVAQYA DTVRPEFYFN
510 520 530 540 550
THPTKREVIT AVRKMKPLDG SALYTGSALD FVRNNLFTSS AGYRAAEGIP
560 570 580 590 600
KLLVLITGGK SLDEISQPAQ ELKRSSIMAF AIGNKGADQA ELEEIAFDSS
610 620 630 640 650
LVFIPAEFRA APLQGMLPGL LAPLRTLSGT PEVHSNKRDI IFLLDGSANV
660 670 680 690 700
GKTNFPYVRD FVMNLVNSLD IGNDNIRVGL VQFSDTPVTE FSLNTYQTKS
710 720 730 740 750
DILGHLRQLQ LQGGSGLNTG SALSYVYANH FTEAGGSRIR EHVPQLLLLL
760 770 780 790 800
TAGQSEDSYL QAANALTRAG ILTFCVGASQ ANKAELEQIA FNPSLVYLMD
810 820 830 840 850
DFSSLPALPQ QLIQPLTTYV SGGVEEVPLA QPESKRDILF LFDGSANLVG
860 870 880 890 900
QFPVVRDFLY KIIDELNVKP EGTRIAVAQY SDDVKVESRF DEHQSKPEIL
910 920 930 940 950
NLVKRMKIKT GKALNLGYAL DYAQRYIFVK SAGSRIEDGV LQFLVLLVAG
960 970 980 990 1000
RSSDRVDGPA SNLKQSGVVP FIFQAKNADP AELEQIVLSP AFILAAESLP
1010 1020 1030 1040 1050
KIGDLHPQIV NLLKSVHNGA PAPVSGEKDV VFLLDGSEGV RSGFPLLKEF
1060 1070 1080 1090 1100
VQRVVESLDV GQDRVRVAVV QYSDRTRPEF YLNSYMNKQD VVNAVRQLTL
1110 1120 1130 1140 1150
LGGPTPNTGA ALEFVLRNIL VSSAGSRITE GVPQLLIVLT ADRSGDDVRN
1160 1170 1180 1190 1200
PSVVVKRGGA VPIGIGIGNA DITEMQTISF IPDFAVAIPT FRQLGTVQQV
1210 1220 1230 1240 1250
ISERVTQLTR EELSRLQPVL QPLPSPGVGG KRDVVFLIDG SQSAGPEFQY
1260 1270 1280 1290 1300
VRTLIERLVD YLDVGFDTTR VAVIQFSDDP KVEFLLNAHS SKDEVQNAVQ
1310 1320 1330 1340 1350
RLRPKGGRQI NVGNALEYVS RNIFKRPLGS RIEEGVPQFL VLISSGKSDD
1360 1370 1380 1390 1400
EVDDPAVELK QFGVAPFTIA RNADQEELVK ISLSPEYVFS VSTFRELPSL
1410 1420 1430 1440 1450
EQKLLTPITT LTSEQIQKLL ASTRYPPPAV ESDAADIVFL IDSSEGVRPD
1460 1470 1480 1490 1500
GFAHIRDFVS RIVRRLNIGP SKVRVGVVQF SNDVFPEFYL KTYRSQAPVL
1510 1520 1530 1540 1550
DAIRRLRLRG GSPLNTGKAL EFVARNLFVK SAGSRIEDGV PQHLVLVLGG
1560 1570 1580 1590 1600
KSQDDVSRFA QVIRSSGIVS LGVGDRNIDR TELQTITNDP RLVFTVREFR
1610 1620 1630 1640 1650
ELPNIEERIM NSFGPSAATP APPGVDTPPP SRPEKKKADI VFLLDGSINF
1660 1670 1680 1690 1700
RRDSFQEVLR FVSEIVDTVY EDGDSIQVGL VQYNSDPTDE FFLKDFSTKR
1710 1720 1730 1740 1750
QIIDAINKVV YKGGRHANTK VGLEHLRVNH FVPEAGSRLD QRVPQIAFVI
1760 1770 1780 1790 1800
TGGKSVEDAQ DVSLALTQRG VKVFAVGVRN IDSEEVGKIA SNSATAFRVG
1810 1820 1830 1840 1850
NVQELSELSE QVLETLHDAM HETLCPGVTD AAKACNLDVI LGFDGSRDQN
1860 1870 1880 1890 1900
VFVAQKGFES KVDAILNRIS QMHRVSCSGG RSPTVRVSVV ANTPSGPVEA
1910 1920 1930 1940 1950
FDFDEYQPEM LEKFRNMRSQ HPYVLTEDTL KVYLNKFRQS SPDSVKVVIH
1960 1970 1980 1990 2000
FTDGADGDLA DLHRASENLR QEGVRALILV GLERVVNLER LMHLEFGRGF
2010 2020 2030 2040 2050
MYDRPLRLNL LDLDYELAEQ LDNIAEKACC GVPCKCSGQR GDRGPIGSIG
2060 2070 2080 2090 2100
PKGIPGEDGY RGYPGDEGGP GERGPPGVNG TQGFQGCPGQ RGVKGSRGFP
2110 2120 2130 2140 2150
GEKGEVGEIG LDGLDGEDGD KGLPGSSGEK GNPGRRGDKG PRGEKGERGD
2160 2170 2180 2190 2200
VGIRGDPGNP GQDSQERGPK GETGDLGPMG VPGRDGVPGG PGETGKNGGF
2210 2220 2230 2240 2250
GRRGPPGAKG NKGGPGQPGF EGEQGTRGAQ GPAGPAGPPG LIGEQGISGP
2260 2270 2280 2290 2300
RGSGGAAGAP GERGRTGPLG RKGEPGEPGP KGGIGNRGPR GETGDDGRDG
2310 2320 2330 2340 2350
VGSEGRRGKK GERGFPGYPG PKGNPGEPGL NGTTGPKGIR GRRGNSGPPG
2360 2370 2380 2390 2400
IVGQKGDPGY PGPAGPKGNR GDSIDQCALI QSIKDKCPCC YGPLECPVFP
2410 2420 2430 2440 2450
TELAFALDTS EGVNQDTFGR MRDVVLSIVN DLTIAESNCP RGARVAVVTY
2460 2470 2480 2490 2500
NNEVTTEIRF ADSKRKSVLL DKIKNLQVAL TSKQQSLETA MSFVARNTFK
2510 2520 2530 2540 2550
RVRNGFLMRK VAVFFSNTPT RASPQLREAV LKLSDAGITP LFLTRQEDRQ
2560 2570 2580 2590 2600
LINALQINNT AVGHALVLPA GRDLTDFLEN VLTCHVCLDI CNIDPSCGFG
2610 2620 2630 2640 2650
SWRPSFRDRR AAGSDVDIDM AFILDSAETT TLFQFNEMKK YIAYLVRQLD
2660 2670 2680 2690 2700
MSPDPKASQH FARVAVVQHA PSESVDNASM PPVKVEFSLT DYGSKEKLVD
2710 2720 2730 2740 2750
FLSRGMTQLQ GTRALGSAIE YTIENVFESA PNPRDLKIVV LMLTGEVPEQ
2760 2770 2780 2790 2800
QLEEAQRVIL QAKCKGYFFV VLGIGRKVNI KEVYTFASEP NDVFFKLVDK
2810 2820 2830 2840 2850
STELNEEPLM RFGRLLPSFV SSENAFYLSP DIRKQCDWFQ GDQPTKNLVK
2860 2870 2880 2890 2900
FGHKQVNVPN NVTSSPTSNP VTTTKPVTTT KPVTTTTKPV TTTTKPVTII
2910 2920 2930 2940 2950
NQPSVKPAAA KPAPAKPVAA KPVATKMATV RPPVAVKPAT AAKPVAAKPA
2960 2970 2980 2990 3000
AVRPPAAAAA KPVATKPEVP RPQAAKPAAT KPATTKPMVK MSREVQVFEI
3010 3020 3030 3040 3050
TENSAKLHWE RAEPPGPYFY DLTVTSAHDQ SLVLKQNLTV TDRVIGGLLA
3060 3070 3080 3090 3100
GQTYHVAVVC YLRSQVRATY HGSFSTKKSQ PPPPQPARSA SSSTINLMVS
3110 3120 3130 3140 3150
TEPLALTETD ICKLPKDEGT CRDFILKWYY DPNTKSCARF WYGGCGGNEN
3160 3170
KFGSQKECEK VCAPVLAKPG VISVMGT
Length:3,177
Mass (Da):343,669
Last modified:October 5, 2010 - v1
Checksum:i56D54CAC4FBB30AF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM015590 Genomic DNA. Translation: ADL14511.1.
RefSeqiNP_004360.2. NM_004369.3.
UniGeneiHs.233240.

Genome annotation databases

GeneIDi1293.
KEGGihsa:1293.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM015590 Genomic DNA. Translation: ADL14511.1.
RefSeqiNP_004360.2. NM_004369.3.
UniGeneiHs.233240.

3D structure databases

ProteinModelPortaliD9ZGF2.
SMRiD9ZGF2. Positions 1027-1222, 3108-3165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000295550.

Proteomic databases

PaxDbiD9ZGF2.
PRIDEiD9ZGF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1293.
KEGGihsa:1293.

Organism-specific databases

CTDi1293.

Phylogenomic databases

eggNOGiKOG3544. Eukaryota.
ENOG41103QR. LUCA.
KOiK06238.
OMAiSWRPSFR.
OrthoDBiEOG091G14M8.
PhylomeDBiD9ZGF2.

Miscellaneous databases

ChiTaRSiCOL6A3. human.
GenomeRNAii1293.

Gene expression databases

BgeeiENSG00000163359.
ExpressionAtlasiD9ZGF2. baseline and differential.
GenevisibleiD9ZGF2. HS.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.40.50.410. 12 hits.
4.10.410.10. 1 hit.
InterProiIPR008160. Collagen.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR002223. Kunitz_BPTI.
IPR020901. Prtase_inh_Kunz-CS.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01391. Collagen. 1 hit.
PF00014. Kunitz_BPTI. 1 hit.
PF00092. VWA. 12 hits.
[Graphical view]
PRINTSiPR00759. BASICPTASE.
SMARTiSM00131. KU. 1 hit.
SM00327. VWA. 12 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 1 hit.
SSF53300. SSF53300. 12 hits.
SSF57362. SSF57362. 1 hit.
PROSITEiPS00280. BPTI_KUNITZ_1. 1 hit.
PS50279. BPTI_KUNITZ_2. 1 hit.
PS50853. FN3. 1 hit.
PS50234. VWFA. 12 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD9ZGF2_HUMAN
AccessioniPrimary (citable) accession number: D9ZGF2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: September 7, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.