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Protein
Submitted name:

Beta-globin

Gene

HBB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Oxygen transportUniRule annotationSAAS annotation, Transport

Keywords - Ligandi

HemeUniRule annotationSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-globinImported
Submitted name:
Hemoglobin, betaImported
Gene namesi
Name:HBBImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PaxDbiD9YZU5.
PRIDEiD9YZU5.

Expressioni

Gene expression databases

BgeeiD9YZU5.
GenevisibleiD9YZU5. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333994.

Structurei

3D structure databases

ProteinModelPortaliD9YZU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 147146GLOBINInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the globin family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
KOiK13823.
OMAiWTRRFFE.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D9YZU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHLTPEEKS AVTALWGKVN VDEVGGEALG RLLVVYPWTQ RFFESFGDLS
60 70 80 90 100
TPDAVMGNPK VKAHGKKVLG AFSDGLAHLD NLKGTFATLS ELHCDKLHVD
110 120 130 140
PENFRLLGNV LVCVLAHHFG KEFTPPVQAA YQKVVAGVAN ALAHKYH
Length:147
Mass (Da):15,998
Last modified:October 5, 2010 - v1
Checksum:iA31F6D621C6556A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU324922 Genomic DNA. Translation: ADL14493.1.
KR028331 Genomic DNA. Translation: ALU64019.1.
KU350152 Genomic DNA. Translation: ALU64020.1.
RefSeqiNP_000509.1. NM_000518.4.
UniGeneiHs.523443.

Genome annotation databases

GeneIDi3043.
KEGGihsa:3043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU324922 Genomic DNA. Translation: ADL14493.1.
KR028331 Genomic DNA. Translation: ALU64019.1.
KU350152 Genomic DNA. Translation: ALU64020.1.
RefSeqiNP_000509.1. NM_000518.4.
UniGeneiHs.523443.

3D structure databases

ProteinModelPortaliD9YZU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333994.

Proteomic databases

PaxDbiD9YZU5.
PRIDEiD9YZU5.

Protocols and materials databases

DNASUi3043.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3043.
KEGGihsa:3043.

Organism-specific databases

CTDi3043.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
KOiK13823.
OMAiWTRRFFE.

Miscellaneous databases

ChiTaRSiHBB. human.
GenomeRNAii3043.

Gene expression databases

BgeeiD9YZU5.
GenevisibleiD9YZU5. HS.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin/Proto.
IPR002337. Haemoglobin_b.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
  2. "Genotype-phenotype correlation and report of novel mutations in ?-globin gene in thalassemia patients."
    Nagar R., Sinha S., Raman R.
    Blood Cells Mol. Dis. 55:10-14(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiD9YZU5_HUMAN
AccessioniPrimary (citable) accession number: D9YZU5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: June 8, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.