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Protein
Submitted name:

Beta-globin

Gene

HBB

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi64Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi93Iron (heme proximal ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Biological processOxygen transportPROSITE-ProRule annotationSAAS annotation, Transport
LigandHemePROSITE-ProRule annotationSAAS annotation, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-globinImported
Submitted name:
Globin A1Imported
Submitted name:
Hemoglobin, betaImported
Gene namesi
Name:HBBImported
Synonyms:GLNA1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Proteomic databases

PaxDbiD9YZU5.

Expressioni

Gene expression databases

BgeeiENSG00000244734.
GenevisibleiD9YZU5. HS.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000333994.

Structurei

3D structure databases

SMRiD9YZU5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 147GLOBINInterPro annotationAdd BLAST146

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
KOiK13823.
OMAiWTRRFFE.
OrthoDBiEOG091G0R7W.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR002337. Haemoglobin_b.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.

Sequencei

Sequence statusi: Complete.

D9YZU5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVHLTPEEKS AVTALWGKVN VDEVGGEALG RLLVVYPWTQ RFFESFGDLS
60 70 80 90 100
TPDAVMGNPK VKAHGKKVLG AFSDGLAHLD NLKGTFATLS ELHCDKLHVD
110 120 130 140
PENFRLLGNV LVCVLAHHFG KEFTPPVQAA YQKVVAGVAN ALAHKYH
Length:147
Mass (Da):15,998
Last modified:October 5, 2010 - v1
Checksum:iA31F6D621C6556A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU324922 Genomic DNA. Translation: ADL14493.1.
KR028331 Genomic DNA. Translation: ALU64019.1.
KU350152 Genomic DNA. Translation: ALU64020.1.
LT548096 Genomic DNA. Translation: SAI82130.1.
RefSeqiNP_000509.1. NM_000518.4.
UniGeneiHs.523443.

Genome annotation databases

GeneIDi3043.
KEGGihsa:3043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GU324922 Genomic DNA. Translation: ADL14493.1.
KR028331 Genomic DNA. Translation: ALU64019.1.
KU350152 Genomic DNA. Translation: ALU64020.1.
LT548096 Genomic DNA. Translation: SAI82130.1.
RefSeqiNP_000509.1. NM_000518.4.
UniGeneiHs.523443.

3D structure databases

SMRiD9YZU5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000333994.

Proteomic databases

PaxDbiD9YZU5.

Protocols and materials databases

DNASUi3043.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3043.
KEGGihsa:3043.

Organism-specific databases

CTDi3043.

Phylogenomic databases

eggNOGiKOG3378. Eukaryota.
COG1018. LUCA.
KOiK13823.
OMAiWTRRFFE.
OrthoDBiEOG091G0R7W.

Miscellaneous databases

ChiTaRSiHBB. human.
GenomeRNAii3043.

Gene expression databases

BgeeiENSG00000244734.
GenevisibleiD9YZU5. HS.

Family and domain databases

CDDicd08925. Hb-beta_like. 1 hit.
InterProiView protein in InterPro
IPR000971. Globin.
IPR009050. Globin-like.
IPR002337. Haemoglobin_b.
PfamiView protein in Pfam
PF00042. Globin. 1 hit.
PRINTSiPR00814. BETAHAEM.
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiView protein in PROSITE
PS01033. GLOBIN. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiD9YZU5_HUMAN
AccessioniPrimary (citable) accession number: D9YZU5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: June 7, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.