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D9U2B1

- KBX22_LYCMC

UniProt

D9U2B1 - KBX22_LYCMC

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Protein

Neurotoxin beta-KTx 12

Gene
N/A
Organism
Lychas mucronatus (Chinese swimming scorpion)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits voltage-gated potassium channel.By similarity

Keywords - Molecular functioni

Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Neurotoxin beta-KTx 12
OrganismiLychas mucronatus (Chinese swimming scorpion)
Taxonomic identifieri172552 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeLychas

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence AnalysisAdd
BLAST
Propeptidei21 – 3919By similarityPRO_0000403848Add
BLAST
Chaini40 – 8950Neurotoxin beta-KTx 12PRO_0000403849Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 76By similarity
Disulfide bondi63 ↔ 81By similarity
Disulfide bondi67 ↔ 83By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR029237. Long_scorpion_toxin.
[Graphical view]
PfamiPF14866. Toxin_38. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

D9U2B1-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MKQYIFFLAL IVLVSTFAEA GKKTEILDKV KKVFSKAKDK ILAGVEDLNN
60 70 80
MSELGCPFID KWCEDHCESK KLVGKCENFD CSCVKLGGK
Length:89
Mass (Da):9,967
Last modified:October 5, 2010 - v1
Checksum:i64AE434C98B73A81
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU163858 mRNA. Translation: ABY26667.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU163858 mRNA. Translation: ABY26667.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

InterProi IPR029237. Long_scorpion_toxin.
[Graphical view ]
Pfami PF14866. Toxin_38. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components."
    Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X.
    BMC Genomics 11:452-452(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Hainan.
    Tissue: Venom gland.

Entry informationi

Entry nameiKBX22_LYCMC
AccessioniPrimary (citable) accession number: D9U2B1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. Scorpion potassium channel toxins
    Nomenclature of scorpion potassium channel toxins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3