D9U2B1 (KBX22_LYCMC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Neurotoxin beta-KTx 12
Organism	Lychas mucronatus (Chinese swimming scorpion)
Taxonomic identifier	172552 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Lychas

Protein attributes

Sequence length	89 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits voltage-gated potassium channel By similarity.
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the long chain scorpion toxin family. Class 2 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Ion channel impairing toxin Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Propeptide	21 – 39	19	By similarity		PRO_0000403848
	Chain	40 – 89	50	Neurotoxin beta-KTx 12		PRO_0000403849
Amino acid modifications
	Disulfide bond	56 ↔ 76		By similarity
	Disulfide bond	63 ↔ 81		By similarity
	Disulfide bond	67 ↔ 83		By similarity

Sequences

	Sequence		Length	Mass (Da)
	D9U2B1 [UniParc]. Last modified October 5, 2010. Version 1. Checksum: 64AE434C98B73A81	FASTA	89	9,967
	10 20 30 40 50 60 MKQYIFFLAL IVLVSTFAEA GKKTEILDKV KKVFSKAKDK ILAGVEDLNN MSELGCPFID 70 80 KWCEDHCESK KLVGKCENFD CSCVKLGGK

References

[1]

"Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components." Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X. BMC Genomics 11:452-452(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Hainan. Tissue: Venom gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU163858 mRNA. Translation: ABY26667.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

KBX22_LYCMC

Accession

Primary (citable) accession number: D9U2B1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2011
Last sequence update:	October 5, 2010
Last modified:	March 6, 2013
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program