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D9U2B1 (KBX22_LYCMC) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurotoxin beta-KTx 12
OrganismLychas mucronatus (Chinese swimming scorpion)
Taxonomic identifier172552 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeLychas

Protein attributes

Sequence length89 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits voltage-gated potassium channel By similarity.

Subcellular location

Secreted By similarity.

Tissue specificity

Expressed by the venom gland.

Sequence similarities

Belongs to the long chain scorpion toxin family. Class 2 subfamily.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionIon channel impairing toxin
Neurotoxin
Potassium channel impairing toxin
Toxin
   PTMDisulfide bond
Gene Ontology (GO)
   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Propeptide21 – 3919 By similarity
PRO_0000403848
Chain40 – 8950Neurotoxin beta-KTx 12
PRO_0000403849

Amino acid modifications

Disulfide bond56 ↔ 76 By similarity
Disulfide bond63 ↔ 81 By similarity
Disulfide bond67 ↔ 83 By similarity

Sequences

Sequence LengthMass (Da)Tools
D9U2B1 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: 64AE434C98B73A81

FASTA899,967
        10         20         30         40         50         60 
MKQYIFFLAL IVLVSTFAEA GKKTEILDKV KKVFSKAKDK ILAGVEDLNN MSELGCPFID 

        70         80 
KWCEDHCESK KLVGKCENFD CSCVKLGGK 

« Hide

References

[1]"Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components."
Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X.
BMC Genomics 11:452-452(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Hainan.
Tissue: Venom gland.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
EU163858 mRNA. Translation: ABY26667.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameKBX22_LYCMC
AccessionPrimary (citable) accession number: D9U2B1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: October 5, 2010
Last modified: October 16, 2013
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Scorpion potassium channel toxins

Nomenclature of scorpion potassium channel toxins and list of entries