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D9U2B1

- KBX22_LYCMC

UniProt

D9U2B1 - KBX22_LYCMC

Protein

Neurotoxin beta-KTx 12

Gene
N/A
Organism
Lychas mucronatus (Chinese swimming scorpion)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Inhibits voltage-gated potassium channel.By similarity

    Keywords - Molecular functioni

    Ion channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurotoxin beta-KTx 12
    OrganismiLychas mucronatus (Chinese swimming scorpion)
    Taxonomic identifieri172552 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaChelicerataArachnidaScorpionesButhidaButhoideaButhidaeLychas

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Propeptidei21 – 3919By similarityPRO_0000403848Add
    BLAST
    Chaini40 – 8950Neurotoxin beta-KTx 12PRO_0000403849Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 76By similarity
    Disulfide bondi63 ↔ 81By similarity
    Disulfide bondi67 ↔ 83By similarity

    Keywords - PTMi

    Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the venom gland.

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR029237. Long_scorpion_toxin.
    [Graphical view]
    PfamiPF14866. Toxin_38. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    D9U2B1-1 [UniParc]FASTAAdd to Basket

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    MKQYIFFLAL IVLVSTFAEA GKKTEILDKV KKVFSKAKDK ILAGVEDLNN   50
    MSELGCPFID KWCEDHCESK KLVGKCENFD CSCVKLGGK 89
    Length:89
    Mass (Da):9,967
    Last modified:October 5, 2010 - v1
    Checksum:i64AE434C98B73A81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU163858 mRNA. Translation: ABY26667.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU163858 mRNA. Translation: ABY26667.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR029237. Long_scorpion_toxin.
    [Graphical view ]
    Pfami PF14866. Toxin_38. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components."
      Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X.
      BMC Genomics 11:452-452(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Hainan.
      Tissue: Venom gland.

    Entry informationi

    Entry nameiKBX22_LYCMC
    AccessioniPrimary (citable) accession number: D9U2B1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 12 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Documents

    1. Scorpion potassium channel toxins
      Nomenclature of scorpion potassium channel toxins and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3