D9U2A8 (KA159_LYCMC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Neurotoxin alpha-KTx 15.9 Alternative name(s): Neurotoxin KTx9
Organism	Lychas mucronatus (Chinese swimming scorpion)
Taxonomic identifier	172552 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Lychas

Protein attributes

Sequence length	60 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits voltage-gated potassium channels By similarity.
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 15 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Molecular function	Ion channel impairing toxin Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	defense response Inferred from electronic annotation. Source: InterPro pathogenesis Inferred from electronic annotation. Source: InterPro
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 60	38	Neurotoxin alpha-KTx 15.9		PRO_0000403829
Amino acid modifications
	Disulfide bond	30 ↔ 51		By similarity
	Disulfide bond	36 ↔ 56		By similarity
	Disulfide bond	40 ↔ 58		By similarity

Sequences

	Sequence		Length	Mass (Da)
	D9U2A8 [UniParc]. Last modified October 5, 2010. Version 1. Checksum: F7B7FA7287261E01	FASTA	60	6,526
	10 20 30 40 50 60 MKIFLPVLVM LILCSMCLLT EGQVSTNKKC SNTSQCYKTC EKVVGVAAGK CMNGKCICYP

References

[1]

"Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components." Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X. BMC Genomics 11:452-452(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Hainan. Tissue: Venom gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU163855 mRNA. Translation: ABY26664.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.30.30.10. 1 hit.
InterPro	IPR003614. Scorpion_toxin-like. IPR001947. Scorpion_toxinS_K_inh. [Graphical view]
Pfam	PF00451. Toxin_2. 1 hit. [Graphical view]
PRINTS	PR00286. CHARYBDTOXIN.
SUPFAM	SSF57095. SSF57095. 1 hit.
PROSITE	PS01138. SCORP_SHORT_TOXIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KA159_LYCMC

Accession

Primary (citable) accession number: D9U2A8

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2011
Last sequence update:	October 5, 2010
Last modified:	May 29, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program