ID   KBX17_LYCMC             Reviewed;          96 AA.
AC   D9U2A7;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   RecName: Full=Neurotoxin beta-KTx7 {ECO:0000305};
DE   AltName: Full=Neurotoxin KTx7 {ECO:0000312|EMBL:ABY26662.1};
DE   Flags: Precursor;
OS   Lychas mucronatus (Chinese swimming scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Lychas.
OX   NCBI_TaxID=172552;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Hainan; TISSUE=Venom gland;
RX   PubMed=20663230; DOI=10.1186/1471-2164-11-452;
RA   Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X.;
RT   "Comparative venom gland transcriptome analysis of the scorpion Lychas
RT   mucronatus reveals intraspecific toxic gene diversity and new venomous
RT   components.";
RL   BMC Genomics 11:452-452(2010).
CC   -!- FUNCTION: Inhibits voltage-gated potassium channel.
CC       {ECO:0000250|UniProtKB:P69940}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:20663230}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:20663230}.
CC   -!- SIMILARITY: Belongs to the long chain scorpion toxin family. Class 1
CC       subfamily. {ECO:0000305}.
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DR   EMBL; EU163853; ABY26662.1; -; mRNA.
DR   AlphaFoldDB; D9U2A7; -.
DR   SMR; D9U2A7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR029237; Long_scorpion_toxin.
DR   Pfam; PF14866; Toxin_38; 1.
DR   PROSITE; PS51862; BSPN_CSAB; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Potassium channel impairing toxin; Secreted; Signal; Toxin.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   PROPEP          22..29
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000403844"
FT   CHAIN           30..96
FT                   /note="Neurotoxin beta-KTx7"
FT                   /id="PRO_0000403845"
FT   DOMAIN          56..93
FT                   /note="BetaSPN-type CS-alpha/beta"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        59..80
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        66..85
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
FT   DISULFID        70..87
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01209"
SQ   SEQUENCE   96 AA;  10777 MW;  95A679D1FEDB087E CRC64;
     MQAKRTILLL LLLGMVALSS CGLREKHVQG LVNKFVPAGI VKNLLQAGIH KVAKMQYGCP
     IIKDYCSFHC NDLEKHEGYC HGTKCKCNIP NQYELF
//