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Protein

Methylglyoxal synthase

Gene

mgsA

Organism
Thermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIB 9385 / NCA 3814) (Clostridium thermosaccharolyticum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.UniRule annotationSAAS annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

Glycerone phosphate = methylglyoxal + phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8SubstrateUniRule annotation1
Binding sitei12SubstrateUniRule annotation1
Active sitei60UniRule annotation1
Active sitei60Proton donor/acceptorUniRule annotation1
Binding sitei87SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

BioCyciTTHE580327:G1GMN-1145-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methylglyoxal synthaseUniRule annotationSAAS annotation (EC:4.2.3.3UniRule annotationSAAS annotation)
Short name:
MGSUniRule annotation
Gene namesi
Name:mgsAUniRule annotation
Ordered Locus Names:Tthe_1132Imported
OrganismiThermoanaerobacterium thermosaccharolyticum (strain ATCC 7956 / DSM 571 / NCIB 9385 / NCA 3814) (Clostridium thermosaccharolyticum)Imported
Taxonomic identifieri580327 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisThermoanaerobacterium
Proteomesi
  • UP000001626 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi580327.Tthe_1132

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini14 – 107MGSInterPro annotationAdd BLAST94

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 37Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the methylglyoxal synthase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4108Z5K Bacteria
COG1803 LUCA
HOGENOMiHOG000283729
KOiK01734
OMAiFAWRELV
OrthoDBiPOG091H04UH

Family and domain databases

CDDicd01422 MGS, 1 hit
Gene3Di3.40.50.1380, 1 hit
HAMAPiMF_00549 Methylglyoxal_synth, 1 hit
InterProiView protein in InterPro
IPR004363 Methylgl_synth
IPR018148 Methylglyoxal_synth_AS
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
PANTHERiPTHR30492 PTHR30492, 1 hit
PfamiView protein in Pfam
PF02142 MGS, 1 hit
PIRSFiPIRSF006614 Methylglyox_syn, 1 hit
SMARTiView protein in SMART
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
TIGRFAMsiTIGR00160 MGSA, 1 hit
PROSITEiView protein in PROSITE
PS01335 METHYLGLYOXAL_SYNTH, 1 hit

Sequencei

Sequence statusi: Complete.

D9TP33-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIALIAHDM KKSLMIDFAI AYKDILKKCN IYATGATGQL VEEATGIKVN
60 70 80 90 100
KFLPGPMGGD QQIGAMIAED KMDLVIFLRD PLTAQPHEPD ILALLRVCDV
110 120 130
HSIPLATNLA TAEVLIKGLD AGLLEWRNAV K
Length:131
Mass (Da):14,239
Last modified:October 5, 2010 - v1
Checksum:i904BEF69D7FCAD16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002171 Genomic DNA Translation: ADL68652.1
RefSeqiWP_013297620.1, NC_014410.1

Genome annotation databases

EnsemblBacteriaiADL68652; ADL68652; Tthe_1132
KEGGittm:Tthe_1132

Similar proteinsi

Entry informationi

Entry nameiD9TP33_THETC
AccessioniPrimary (citable) accession number: D9TP33
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: April 25, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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