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D9TD85 (D9TD85_MICAI) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Non-canonical purine NTP pyrophosphatase HAMAP-Rule MF_01405
EC=3.6.1.19 HAMAP-Rule MF_01405
Alternative name(s):
Non-standard purine NTP pyrophosphatase HAMAP-Rule MF_01405
Nucleoside-triphosphate diphosphatase HAMAP-Rule MF_01405
Nucleoside-triphosphate pyrophosphatase HAMAP-Rule MF_01405
Gene names
Ordered Locus Names:Micau_1161
OrganismMicromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442) [Complete proteome] [HAMAP] EMBL ADL44723.1
Taxonomic identifier644283 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Micromonospora ›

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity. HAMAP-Rule MF_01405

Catalytic activity

A nucleoside triphosphate + H2O = a nucleotide + diphosphate. SAAS SAAS002637 HAMAP-Rule MF_01405

Cofactor

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity. SAAS SAAS002637 HAMAP-Rule MF_01405

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01405 SAAS SAAS002637

Sequence similarities

Belongs to the HAM1 NTPase family. RuleBase RU003781 HAMAP-Rule MF_01405

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region8 – 136Substrate binding By similarity HAMAP-Rule MF_01405
Region74 – 752Substrate binding By similarity HAMAP-Rule MF_01405

Sites

Metal binding741Magnesium or manganese By similarity HAMAP-Rule MF_01405
Binding site1601Substrate By similarity HAMAP-Rule MF_01405
Binding site1801Substrate By similarity HAMAP-Rule MF_01405
Binding site1861Substrate By similarity HAMAP-Rule MF_01405

Sequences

Sequence LengthMass (Da)Tools
D9TD85 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: 7198EE5A56F539D9

FASTA20521,912
        10         20         30         40         50         60 
MNKVLLATRN RKKLVELQRI LDGALGAHRI ALLGLDDVEE YPELPETGLT FGENALIKAR 

        70         80         90        100        110        120 
EGCRRTGLPT IADDSGLAVD ALNGMPGVFS ARWSGGHGDD RANLQLVLDQ VADVPDEHRG 

       130        140        150        160        170        180 
AAFVCTVALV LPGGKEHLVD GRQSGRLLRA PRGDGGFGYD PIFLGDGQER TNAELTPEEK 

       190        200 
DAVSHRGKAL RELAKLVAKV LPPAA

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References

[1]"Complete sequence of Micromonospora aurantiaca ATCC 27029."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G., Hirsch A.M., Woyke T.
Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002162 Genomic DNA. Translation: ADL44723.1.
RefSeqYP_003834299.1. NC_014391.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADL44723; ADL44723; Micau_1161.
GeneID9599231.
KEGGmau:Micau_1161.
PATRIC42388023. VBIMicAur74833_1180.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000293319.
KOK02428.
OMAGEAHNDA.

Enzyme and pathway databases

BioCycMAUR644283:GHOD-1176-MONOMER.

Family and domain databases

HAMAPMF_01405. Non_canon_purine_NTPase.
InterProIPR002637. Ham1p-like.
IPR020922. NTPase.
[Graphical view]
PANTHERPTHR11067. PTHR11067. 1 hit.
PfamPF01725. Ham1p_like. 1 hit.
[Graphical view]
TIGRFAMsTIGR00042. TIGR00042. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD9TD85_MICAI
AccessionPrimary (citable) accession number: D9TD85
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: May 29, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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