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D9TAL9

- D9TAL9_MICAI

UniProt

D9TAL9 - D9TAL9_MICAI

Protein

Probable DNA ligase

Gene

lig

Organism
Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 24 (01 Oct 2014)
      Sequence version 1 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei209 – 2091ATPUniRule annotation
    Active sitei211 – 2111N6-AMP-lysine intermediateUniRule annotation
    Binding sitei216 – 2161ATPUniRule annotation
    Binding sitei231 – 2311ATPUniRule annotation
    Binding sitei260 – 2601ATPUniRule annotation
    Binding sitei315 – 3151ATPUniRule annotation
    Binding sitei387 – 3871ATPUniRule annotation
    Binding sitei393 – 3931ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMAUR644283:GHOD-5010-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    Ordered Locus Names:Micau_4966Imported
    OrganismiMicromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)Imported
    Taxonomic identifieri644283 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeMicromonospora
    ProteomesiUP000001908: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000036008.
    KOiK01971.
    OMAiARVQVHK.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 2 hits.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D9TAL9-1 [UniParc]FASTAAdd to Basket

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    MRFAELAATS AAVGATSGRR AKVELLAAAL RGLEPGEIPA GAGYLAGELR    50
    QRQTGVGWAG LRDLPPPAAE PTLTVAAVDA AIEEISRVAG AGSQARRREL 100
    VGRLFAAATA DEQRLLTGLF RGELRQGAQA GLLADAVARA ADVPVTAVRR 150
    ALLLAGDLRA VAVAALTGGA AALAGFGLQV GRPLAPMLAQ SAPSVDEALT 200
    ATGVPAMVDV KLDGIRIQVH RSGPDIAVFT RSLDEITGRL PQVVAAVRAL 250
    PARELVLDGE AIGLDAAGRP LPFQETSSRA ARRTTPSTTG QAPVAPAVLA 300
    AAERTGEPVL TPYFFDLLHL DGTDLIDAPG RERWAALAGA VDASLLVDRI 350
    EVDDVEQAAT AFAAAVDAGQ EGVVVKDPAA PYDAGRRGSA WVKVKPRHTL 400
    DLVVLAVEWG SGRREGWLSN LHLGARDPRT GEFVMLGKTF KGLTDELLRW 450
    QTERFLSLAV EKGDWVVRVR PEQVVEIAFD GVQTSSRYPG GMALRFARVL 500
    RYRDDKTAAE ADTIDAVRAI HAGRVTG 527
    Length:527
    Mass (Da):55,322
    Last modified:October 5, 2010 - v1
    Checksum:i85C36A68BE3D5D71
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002162 Genomic DNA. Translation: ADL48475.1.
    RefSeqiWP_013288089.1. NC_014391.1.
    YP_003838051.1. NC_014391.1.

    Genome annotation databases

    EnsemblBacteriaiADL48475; ADL48475; Micau_4966.
    GeneIDi9603065.
    KEGGimau:Micau_4966.
    PATRICi42395721. VBIMicAur74833_5000.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002162 Genomic DNA. Translation: ADL48475.1 .
    RefSeqi WP_013288089.1. NC_014391.1.
    YP_003838051.1. NC_014391.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADL48475 ; ADL48475 ; Micau_4966 .
    GeneIDi 9603065.
    KEGGi mau:Micau_4966.
    PATRICi 42395721. VBIMicAur74833_5000.

    Phylogenomic databases

    HOGENOMi HOG000036008.
    KOi K01971.
    OMAi ARVQVHK.

    Enzyme and pathway databases

    BioCyci MAUR644283:GHOD-5010-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 2 hits.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Micromonospora aurantiaca ATCC 27029."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G., Hirsch A.M., Woyke T.
      Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442Imported.

    Entry informationi

    Entry nameiD9TAL9_MICAI
    AccessioniPrimary (citable) accession number: D9TAL9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 24 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3