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D9TAL9 (D9TAL9_MICAI) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 18. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable DNA ligase HAMAP-Rule MF_00407
EC=6.5.1.1 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
Ordered Locus Names:Micau_4966
OrganismMicromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442) [Complete proteome] [HAMAP] EMBL ADL48475.1
Taxonomic identifier644283 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Micromonospora ›

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407 RuleBase RU000617

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2111N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2091ATP By similarity HAMAP-Rule MF_00407
Binding site2161ATP By similarity HAMAP-Rule MF_00407
Binding site2311ATP By similarity HAMAP-Rule MF_00407
Binding site2601ATP By similarity HAMAP-Rule MF_00407
Binding site3151ATP By similarity HAMAP-Rule MF_00407
Binding site3871ATP By similarity HAMAP-Rule MF_00407
Binding site3931ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
D9TAL9 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: 85C36A68BE3D5D71

FASTA52755,322
        10         20         30         40         50         60 
MRFAELAATS AAVGATSGRR AKVELLAAAL RGLEPGEIPA GAGYLAGELR QRQTGVGWAG 

        70         80         90        100        110        120 
LRDLPPPAAE PTLTVAAVDA AIEEISRVAG AGSQARRREL VGRLFAAATA DEQRLLTGLF 

       130        140        150        160        170        180 
RGELRQGAQA GLLADAVARA ADVPVTAVRR ALLLAGDLRA VAVAALTGGA AALAGFGLQV 

       190        200        210        220        230        240 
GRPLAPMLAQ SAPSVDEALT ATGVPAMVDV KLDGIRIQVH RSGPDIAVFT RSLDEITGRL 

       250        260        270        280        290        300 
PQVVAAVRAL PARELVLDGE AIGLDAAGRP LPFQETSSRA ARRTTPSTTG QAPVAPAVLA 

       310        320        330        340        350        360 
AAERTGEPVL TPYFFDLLHL DGTDLIDAPG RERWAALAGA VDASLLVDRI EVDDVEQAAT 

       370        380        390        400        410        420 
AFAAAVDAGQ EGVVVKDPAA PYDAGRRGSA WVKVKPRHTL DLVVLAVEWG SGRREGWLSN 

       430        440        450        460        470        480 
LHLGARDPRT GEFVMLGKTF KGLTDELLRW QTERFLSLAV EKGDWVVRVR PEQVVEIAFD 

       490        500        510        520 
GVQTSSRYPG GMALRFARVL RYRDDKTAAE ADTIDAVRAI HAGRVTG

« Hide

References

[1]"Complete sequence of Micromonospora aurantiaca ATCC 27029."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G., Hirsch A.M., Woyke T.
Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002162 Genomic DNA. Translation: ADL48475.1.
RefSeqYP_003838051.1. NC_014391.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADL48475; ADL48475; Micau_4966.
GeneID9603065.
KEGGmau:Micau_4966.
PATRIC42395721. VBIMicAur74833_5000.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000036008.
KOK01971.
OMAARVQVHK.

Enzyme and pathway databases

BioCycMAUR644283:GHOD-5010-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF50249. Nucleic_acid_OB. 1 hit.
SSF117018. SSF117018. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD9TAL9_MICAI
AccessionPrimary (citable) accession number: D9TAL9
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: May 1, 2013
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info