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Protein

Probable DNA ligase

Gene

lig

Organism
Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / BCRC 12538 / CBS 129.76 / JCM 10878 / NBRC 16125 / NRRL B-16091 / INA 9442)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n)-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)(m) = (deoxyribonucleotide)(n+m) + AMP + diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei209ATPUniRule annotation1
Active sitei211N6-AMP-lysine intermediateUniRule annotation1
Binding sitei216ATPUniRule annotation1
Binding sitei231ATPUniRule annotation1
Binding sitei260ATPUniRule annotation1
Binding sitei315ATPUniRule annotation1
Binding sitei387ATPUniRule annotation1
Binding sitei393ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationImported
Biological processCell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMAUR644283:G1GMI-4999-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]UniRule annotation
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Micau_4966Imported
OrganismiMicromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / BCRC 12538 / CBS 129.76 / JCM 10878 / NBRC 16125 / NRRL B-16091 / INA 9442)Imported
Taxonomic identifieri644283 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicromonosporalesMicromonosporaceaeMicromonospora
Proteomesi
  • UP000001908 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi644283.Micau_4966

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini313 – 427DNA_LIGASE_A3InterPro annotationAdd BLAST115

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107RYT Bacteria
COG1793 LUCA
HOGENOMiHOG000036008
KOiK10747
OMAiWLFEESY
OrthoDBiPOG091H0BGA

Family and domain databases

Gene3Di1.10.3260.10, 1 hit
HAMAPiMF_00407 DNA_ligase, 1 hit
InterProiView protein in InterPro
IPR022865 DNA_ligae_ATP-dep_bac/arc
IPR000977 DNA_ligase_ATP-dep
IPR012309 DNA_ligase_ATP-dep_C
IPR012310 DNA_ligase_ATP-dep_cent
IPR016059 DNA_ligase_ATP-dep_CS
IPR012308 DNA_ligase_ATP-dep_N
IPR036599 DNA_ligase_N_sf
IPR012340 NA-bd_OB-fold
PfamiView protein in Pfam
PF04679 DNA_ligase_A_C, 1 hit
PF01068 DNA_ligase_A_M, 1 hit
PF04675 DNA_ligase_A_N, 1 hit
SUPFAMiSSF117018 SSF117018, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR00574 dnl1, 1 hit
PROSITEiView protein in PROSITE
PS00697 DNA_LIGASE_A1, 1 hit
PS50160 DNA_LIGASE_A3, 1 hit

Sequencei

Sequence statusi: Complete.

D9TAL9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFAELAATS AAVGATSGRR AKVELLAAAL RGLEPGEIPA GAGYLAGELR
60 70 80 90 100
QRQTGVGWAG LRDLPPPAAE PTLTVAAVDA AIEEISRVAG AGSQARRREL
110 120 130 140 150
VGRLFAAATA DEQRLLTGLF RGELRQGAQA GLLADAVARA ADVPVTAVRR
160 170 180 190 200
ALLLAGDLRA VAVAALTGGA AALAGFGLQV GRPLAPMLAQ SAPSVDEALT
210 220 230 240 250
ATGVPAMVDV KLDGIRIQVH RSGPDIAVFT RSLDEITGRL PQVVAAVRAL
260 270 280 290 300
PARELVLDGE AIGLDAAGRP LPFQETSSRA ARRTTPSTTG QAPVAPAVLA
310 320 330 340 350
AAERTGEPVL TPYFFDLLHL DGTDLIDAPG RERWAALAGA VDASLLVDRI
360 370 380 390 400
EVDDVEQAAT AFAAAVDAGQ EGVVVKDPAA PYDAGRRGSA WVKVKPRHTL
410 420 430 440 450
DLVVLAVEWG SGRREGWLSN LHLGARDPRT GEFVMLGKTF KGLTDELLRW
460 470 480 490 500
QTERFLSLAV EKGDWVVRVR PEQVVEIAFD GVQTSSRYPG GMALRFARVL
510 520
RYRDDKTAAE ADTIDAVRAI HAGRVTG
Length:527
Mass (Da):55,322
Last modified:October 5, 2010 - v1
Checksum:i85C36A68BE3D5D71
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002162 Genomic DNA Translation: ADL48475.1
RefSeqiWP_013288089.1, NC_014391.1

Genome annotation databases

EnsemblBacteriaiADL48475; ADL48475; Micau_4966
GeneIDi32165520
KEGGimau:Micau_4966

Similar proteinsi

Entry informationi

Entry nameiD9TAL9_MICAI
AccessioniPrimary (citable) accession number: D9TAL9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: March 28, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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