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D9TAL9

- D9TAL9_MICAI

UniProt

D9TAL9 - D9TAL9_MICAI

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Protein
Probable DNA ligase
Gene
lig, Micau_4966
Organism
Micromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei209 – 2091ATP By similarityUniRule annotation
Active sitei211 – 2111N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei216 – 2161ATP By similarityUniRule annotation
Binding sitei231 – 2311ATP By similarityUniRule annotation
Binding sitei260 – 2601ATP By similarityUniRule annotation
Binding sitei315 – 3151ATP By similarityUniRule annotation
Binding sitei387 – 3871ATP By similarityUniRule annotation
Binding sitei393 – 3931ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. DNA ligation involved in DNA repair Source: InterPro
  2. DNA recombination Source: UniProtKB-HAMAP
  3. DNA replication Source: UniProtKB-HAMAP
  4. cell cycle Source: UniProtKB-KW
  5. cell division Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMAUR644283:GHOD-5010-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
Ordered Locus Names:Micau_4966Imported
OrganismiMicromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442)Imported
Taxonomic identifieri644283 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesMicromonosporineaeMicromonosporaceaeMicromonospora
ProteomesiUP000001908: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the ATP-dependent DNA ligase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000036008.
KOiK01971.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D9TAL9-1 [UniParc]FASTAAdd to Basket

« Hide

MRFAELAATS AAVGATSGRR AKVELLAAAL RGLEPGEIPA GAGYLAGELR    50
QRQTGVGWAG LRDLPPPAAE PTLTVAAVDA AIEEISRVAG AGSQARRREL 100
VGRLFAAATA DEQRLLTGLF RGELRQGAQA GLLADAVARA ADVPVTAVRR 150
ALLLAGDLRA VAVAALTGGA AALAGFGLQV GRPLAPMLAQ SAPSVDEALT 200
ATGVPAMVDV KLDGIRIQVH RSGPDIAVFT RSLDEITGRL PQVVAAVRAL 250
PARELVLDGE AIGLDAAGRP LPFQETSSRA ARRTTPSTTG QAPVAPAVLA 300
AAERTGEPVL TPYFFDLLHL DGTDLIDAPG RERWAALAGA VDASLLVDRI 350
EVDDVEQAAT AFAAAVDAGQ EGVVVKDPAA PYDAGRRGSA WVKVKPRHTL 400
DLVVLAVEWG SGRREGWLSN LHLGARDPRT GEFVMLGKTF KGLTDELLRW 450
QTERFLSLAV EKGDWVVRVR PEQVVEIAFD GVQTSSRYPG GMALRFARVL 500
RYRDDKTAAE ADTIDAVRAI HAGRVTG 527
Length:527
Mass (Da):55,322
Last modified:October 5, 2010 - v1
Checksum:i85C36A68BE3D5D71
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002162 Genomic DNA. Translation: ADL48475.1.
RefSeqiWP_013288089.1. NC_014391.1.
YP_003838051.1. NC_014391.1.

Genome annotation databases

EnsemblBacteriaiADL48475; ADL48475; Micau_4966.
GeneIDi9603065.
KEGGimau:Micau_4966.
PATRICi42395721. VBIMicAur74833_5000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002162 Genomic DNA. Translation: ADL48475.1 .
RefSeqi WP_013288089.1. NC_014391.1.
YP_003838051.1. NC_014391.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADL48475 ; ADL48475 ; Micau_4966 .
GeneIDi 9603065.
KEGGi mau:Micau_4966.
PATRICi 42395721. VBIMicAur74833_5000.

Phylogenomic databases

HOGENOMi HOG000036008.
KOi K01971.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci MAUR644283:GHOD-5010-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 2 hits.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Micromonospora aurantiaca ATCC 27029."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G., Hirsch A.M., Woyke T.
    Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442.

Entry informationi

Entry nameiD9TAL9_MICAI
AccessioniPrimary (citable) accession number: D9TAL9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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