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D9T0J2 (D9T0J2_MICAI) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Pantothenate synthetase HAMAP-Rule MF_00158
Short name=PS HAMAP-Rule MF_00158
EC=6.3.2.1 HAMAP-Rule MF_00158
Alternative name(s):
Pantoate--beta-alanine ligase HAMAP-Rule MF_00158
Pantoate-activating enzyme HAMAP-Rule MF_00158
Gene names
Name:panC HAMAP-Rule MF_00158
Ordered Locus Names:Micau_5858
OrganismMicromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442) [Complete proteome] [HAMAP] EMBL ADL49362.1
Taxonomic identifier644283 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Micromonospora ›

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate By similarity. HAMAP-Rule MF_00158

Catalytic activity

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate. HAMAP-Rule MF_00158 SAAS SAAS003721

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1. HAMAP-Rule MF_00158 SAAS SAAS003721

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00158

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00158.

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism By similarity. HAMAP-Rule MF_00158

Sequence similarities

Belongs to the pantothenate synthetase family. HAMAP-Rule MF_00158

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding28 – 358ATP By similarity HAMAP-Rule MF_00158
Nucleotide binding146 – 1494ATP By similarity HAMAP-Rule MF_00158
Nucleotide binding183 – 1864ATP By similarity HAMAP-Rule MF_00158

Sites

Active site351Proton donor By similarity HAMAP-Rule MF_00158
Binding site591Beta-alanine By similarity HAMAP-Rule MF_00158
Binding site591Pantoate By similarity HAMAP-Rule MF_00158
Binding site1521Pantoate By similarity HAMAP-Rule MF_00158
Binding site1751ATP; via amide nitrogen and carbonyl oxygen By similarity HAMAP-Rule MF_00158

Sequences

Sequence LengthMass (Da)Tools
D9T0J2 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: 227AA0A99EECF7E6

FASTA28030,266
        10         20         30         40         50         60 
MAEVLHTRKE LAAAREAMAG PVGVVMTMGA LHAGHEALLR AARERAGHVI VTIFVNPLQF 

        70         80         90        100        110        120 
GPNEDFDRYP RTLDTDLEIC RRAGVDVVFA PSVTEMYPEG RPTVRLDPGP LGEDLEGLSR 

       130        140        150        160        170        180 
PGFFHGVLTV VMKLLQLTRP DLAFFGEKDY QQLTLVRRMV RDLDVPAEIV GVPTVREPDG 

       190        200        210        220        230        240 
LAMSSRNRYL SAPERETALS LSAALRAGAT AAERGEDAGA VLAAAHRAFD APDARLDYLV 

       250        260        270        280 
LTDTELEPGP VAGPARLLIA AWVGATRLID NTAIHLAPRP

« Hide

References

[1]"Complete sequence of Micromonospora aurantiaca ATCC 27029."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G., Hirsch A.M., Woyke T.
Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002162 Genomic DNA. Translation: ADL49362.1.
RefSeqYP_003838938.1. NC_014391.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADL49362; ADL49362; Micau_5858.
GeneID9603966.
KEGGmau:Micau_5858.
PATRIC42397541. VBIMicAur74833_5906.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000175516.
KOK01918.
OMAEDFGSYP.

Enzyme and pathway databases

BioCycMAUR644283:GHOD-5911-MONOMER.
UniPathwayUPA00028; UER00005.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_00158. PanC.
InterProIPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00018. panC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameD9T0J2_MICAI
AccessionPrimary (citable) accession number: D9T0J2
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: May 1, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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