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D9SXG3 (D9SXG3_MICAI) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047
EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Micau_1344
OrganismMicromonospora aurantiaca (strain ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442) [Complete proteome] [HAMAP] EMBL ADL44906.1
Taxonomic identifier644283 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Micromonospora ›

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. SAAS SAAS005905 HAMAP-Rule MF_00047

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. SAAS SAAS005905 HAMAP-Rule MF_00047

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. SAAS SAAS005905 HAMAP-Rule MF_00047

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. SAAS SAAS005905 HAMAP-Rule MF_00047

Subcellular location

Cytoplasm By similarity SAAS SAAS005905 HAMAP-Rule MF_00047.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. SAAS SAAS005905 HAMAP-Rule MF_00047

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain152 – 358207ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding179 – 23456ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3121Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3251Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3251Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3271Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
D9SXG3 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: 1C475ABF5DEA2ADF

FASTA36739,069
        10         20         30         40         50         60 
MTTPGKTRVA IVFGGRSPEH GISCVSAGSV LAALDPDEFE VVPVGITRQG QWVLASGDPS 

        70         80         90        100        110        120 
GLAIADRKLP EITAGSGAEL VLRADPAVGG LMVLDPAQGP VALADVDVVF PVLHGAYGED 

       130        140        150        160        170        180 
GTIQGMLEMA DIPYVGANVF ASAAAMDKEF TKKLCAAEGI PVGPYAVLRA GMSLSDEDKE 

       190        200        210        220        230        240 
RLGLPVFVKP SRAGSSFGIT KVDDWADLDA ALVTAREIDS KVLVEGAVVG REIECGVLEG 

       250        260        270        280        290        300 
EAGGAPEASV LAEVRMIGDR DWYDFEAKYI FADEVCEYDV PADLPEPVAR QVRDYATRAF 

       310        320        330        340        350        360 
TALDCSGLAR VDFFVTPQMD VYLNEINTMP GFTPTSMFPR MWSASGLEYP KLVNRLIRTA 


LHRRAGR

« Hide

References

[1]"Complete sequence of Micromonospora aurantiaca ATCC 27029."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Cheng J.-F., Bruce D., Goodwin L., Pitluck S., Chertkov O., Detter J.C., Han C., Tapia R., Land M., Hauser L., Chang Y.-J., Jeffries C., Kyrpides N., Ivanova N., Ovchinnikova G., Hirsch A.M., Woyke T.
Submitted (AUG-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27029 / DSM 43813 / JCM 10878 / NBRC 16125 / INA 9442.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002162 Genomic DNA. Translation: ADL44906.1.
RefSeqYP_003834482.1. NC_014391.1.

3D structure databases

ProteinModelPortalD9SXG3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADL44906; ADL44906; Micau_1344.
GeneID9599421.
KEGGmau:Micau_1344.
PATRIC42388411. VBIMicAur74833_1367.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000011593.
KOK01921.
OMALLHGPFG.

Enzyme and pathway databases

BioCycMAUR644283:GHOD-1366-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD9SXG3_MICAI
AccessionPrimary (citable) accession number: D9SXG3
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: May 1, 2013
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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