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Protein

Alanine racemase

Gene

Galf_0614

Organism
Gallionella capsiferriformans (strain ES-2) (Gallionella ferruginea capsiferriformans (strain ES-2))
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway:iD-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Galf_0614)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei129 – 1291SubstrateUniRule annotation
Active sitei251 – 2511Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei299 – 2991Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciGCAP395494:GHXI-634-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Galf_0614Imported
OrganismiGallionella capsiferriformans (strain ES-2) (Gallionella ferruginea capsiferriformans (strain ES-2))Imported
Taxonomic identifieri395494 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaGallionellalesGallionellaceaeGallionella
ProteomesiUP000001235 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi395494.Galf_0614.

Structurei

3D structure databases

ProteinModelPortaliD9SCW7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.
OMAiDKYRLTT.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D9SCW7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRPIQALID QNALENNLHV ARRAASSRIM AVIKADGYGH GLLRVAEALA
60 70 80 90 100
AAEGFALLDI QDAVRLREAG YRQTILLLEG FFDAADLALI AAYELTTVIH
110 120 130 140 150
SNWQIALLDA YPGRGTLDVW LKVNSGMHRL GFSPEGVNAA MKSLRAHAAV
160 170 180 190 200
REITLMSHFS HADEPRGVSL QLALINEIAS EYRVARSLAN SAALLRYPAT
210 220 230 240 250
HGDWVRPGVM LYGASPFADT SAQQLGLKPV MTLSSRIIAI QNLQAGDEVG
260 270 280 290 300
YAGVFRADRT MRIGVVACGY ADGYPRHAPN GTPVLVDGRK TQLLGRISMD
310 320 330 340 350
MLCVDLTALP DSGMGAQVTL WGQGLPVETV AAAAGTISYE LMCGLTARVP

VRL
Length:353
Mass (Da):37,881
Last modified:October 5, 2010 - v1
Checksum:i6F8D68A0B6655292
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002159 Genomic DNA. Translation: ADL54656.1.
RefSeqiWP_013292598.1. NC_014394.1.

Genome annotation databases

EnsemblBacteriaiADL54656; ADL54656; Galf_0614.
KEGGigca:Galf_0614.
PATRICi42337826. VBIGalCap53152_0626.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002159 Genomic DNA. Translation: ADL54656.1.
RefSeqiWP_013292598.1. NC_014394.1.

3D structure databases

ProteinModelPortaliD9SCW7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi395494.Galf_0614.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADL54656; ADL54656; Galf_0614.
KEGGigca:Galf_0614.
PATRICi42337826. VBIGalCap53152_0626.

Phylogenomic databases

HOGENOMiHOG000031446.
KOiK01775.
OMAiDKYRLTT.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciGCAP395494:GHXI-634-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ES-2Imported.

Entry informationi

Entry nameiD9SCW7_GALCS
AccessioniPrimary (citable) accession number: D9SCW7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: July 22, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.