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D9S2K5

- D9S2K5_THEOJ

UniProt

D9S2K5 - D9S2K5_THEOJ

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Protein

ATP-dependent 6-phosphofructokinase

Gene
pfkA, Toce_0870
Organism
Thermosediminibacter oceani (strain ATCC BAA-1034 / DSM 16646 / JW/IW-1228P)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis By similarity.UniRule annotationSAAS annotations

Catalytic activityi

ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Enzyme regulationi

Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei11 – 111ATP; via amide nitrogen By similarityUniRule annotation
Metal bindingi103 – 1031Magnesium; catalytic By similarityUniRule annotation
Active sitei127 – 1271Proton acceptor By similarityUniRule annotation
Binding sitei154 – 1541Allosteric activator ADP By similarityUniRule annotation
Binding sitei162 – 1621Substrate; shared with dimeric partner By similarityUniRule annotation
Binding sitei211 – 2111Allosteric activator ADP By similarityUniRule annotation
Binding sitei222 – 2221Substrate By similarityUniRule annotation
Binding sitei243 – 2431Substrate; shared with dimeric partner By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 732ATP By similarityUniRule annotation
Nucleotide bindingi102 – 1054ATP By similarityUniRule annotation

GO - Molecular functioni

  1. 6-phosphofructokinase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. fructose 6-phosphate metabolic process Source: InterPro
  2. glycolytic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, MagnesiumUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding

Enzyme and pathway databases

BioCyciTOCE555079:GHIS-879-MONOMER.
UniPathwayiUPA00109; UER00182.

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent 6-phosphofructokinaseUniRule annotation (EC:2.7.1.11UniRule annotation)
Short name:
ATP-PFKUniRule annotation
Short name:
PhosphofructokinaseUniRule annotation
Alternative name(s):
Phosphohexokinase
Gene namesi
Name:pfkAUniRule annotationImported
Ordered Locus Names:Toce_0870Imported
OrganismiThermosediminibacter oceani (strain ATCC BAA-1034 / DSM 16646 / JW/IW-1228P)Imported
Taxonomic identifieri555079 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaThermoanaerobacteralesThermoanaerobacterales Family III. Incertae SedisThermosediminibacter
ProteomesiUP000000272: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. 6-phosphofructokinase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 255Allosteric activator ADP binding; shared with dimeric partner By similarityUniRule annotation
Regioni125 – 1273Substrate binding By similarityUniRule annotation
Regioni169 – 1713Substrate binding By similarityUniRule annotation
Regioni185 – 1873Allosteric activator ADP binding By similarityUniRule annotation
Regioni213 – 2153Allosteric activator ADP binding By similarityUniRule annotation
Regioni249 – 2524Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000248869.
KOiK00850.
OMAiGFGGRCV.

Family and domain databases

HAMAPiMF_00339. Phosphofructokinase.
InterProiIPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view]
PfamiPF00365. PFK. 1 hit.
[Graphical view]
PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSiPR00476. PHFRCTKINASE.
SUPFAMiSSF53784. SSF53784. 1 hit.
TIGRFAMsiTIGR02482. PFKA_ATP. 1 hit.
PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D9S2K5-1 [UniParc]FASTAAdd to Basket

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MKRIGILTSG GDAPGMNAAI RAVVRSGIYN DMEVYGIRRG YAGLINGDFV    50
KMDLGSVGDI IHRGGTILRT ARSEEFKTPE GMEKALKNIE ALGLEGLVVI 100
GGDGSFRGAI ELSKRGVATI GIPGTIDNDI PFTDYSIGFD TAVNTVVEAV 150
NKIRDTATSH ERTFIIEVMG RESGNLALYS GVACGAETIL VPEMPFTIKD 200
VCEKIMSGFR RGKLHSIIIL AEGAGQGFDV GREIKNITGF ETRIIVLGHL 250
QRGGTPTAFD RILASQMGGK AVELLKSGVS NKMVGWVKGE LLVTDLEQIL 300
TTNKPFNMEL YELANILSI 319
Length:319
Mass (Da):34,238
Last modified:October 5, 2010 - v1
Checksum:i43F266758F2DD5F6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002131 Genomic DNA. Translation: ADL07632.1.
RefSeqiYP_003825255.1. NC_014377.1.

Genome annotation databases

EnsemblBacteriaiADL07632; ADL07632; Toce_0870.
GeneIDi9510506.
KEGGitoc:Toce_0870.
PATRICi42456868. VBITheOce34679_0944.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002131 Genomic DNA. Translation: ADL07632.1 .
RefSeqi YP_003825255.1. NC_014377.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADL07632 ; ADL07632 ; Toce_0870 .
GeneIDi 9510506.
KEGGi toc:Toce_0870.
PATRICi 42456868. VBITheOce34679_0944.

Phylogenomic databases

HOGENOMi HOG000248869.
KOi K00850.
OMAi GFGGRCV.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00182 .
BioCyci TOCE555079:GHIS-879-MONOMER.

Family and domain databases

HAMAPi MF_00339. Phosphofructokinase.
InterProi IPR012003. ATP_PFK_prok.
IPR012828. PFKA_ATP.
IPR022953. Phosphofructokinase.
IPR015912. Phosphofructokinase_CS.
IPR000023. Phosphofructokinase_dom.
[Graphical view ]
Pfami PF00365. PFK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
PRINTSi PR00476. PHFRCTKINASE.
SUPFAMi SSF53784. SSF53784. 1 hit.
TIGRFAMsi TIGR02482. PFKA_ATP. 1 hit.
PROSITEi PS00433. PHOSPHOFRUCTOKINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-1034 / DSM 16646 / JW/IW-1228P.

Entry informationi

Entry nameiD9S2K5_THEOJ
AccessioniPrimary (citable) accession number: D9S2K5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: July 9, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Allosteric enzymeUniRule annotation, Complete proteome

External Data

Dasty 3

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