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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Prevotella melaninogenica (strain ATCC 25845 / DSM 7089 / JCM 6325 / VPI 2381 / B282) (Bacteroides melaninogenicus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi171 – 178ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation
Biological processDNA replicationUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciPMEL553174-HMP:G1GM7-1449-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotationSAAS annotation
Gene namesi
Name:dnaAUniRule annotationImported
Ordered Locus Names:HMPREF0659_A6416Imported
OrganismiPrevotella melaninogenica (strain ATCC 25845 / DSM 7089 / JCM 6325 / VPI 2381 / B282) (Bacteroides melaninogenicus)Imported
Taxonomic identifieri553174 [NCBI]
Taxonomic lineageiBacteriaBacteroidetesBacteroidiaBacteroidalesPrevotellaceaePrevotella
Proteomesi
  • UP000001498 Componenti: Chromosome II

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi553174.HMPREF0659_A6416

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini163 – 295AAAInterPro annotationAdd BLAST133
Domaini374 – 443Bac_DnaA_CInterPro annotationAdd BLAST70

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CI4 Bacteria
COG0593 LUCA
HOGENOMiHOG000235658
KOiK02313
OMAiVENWVKD

Family and domain databases

CDDicd06571 Bac_DnaA_C, 1 hit
Gene3Di1.10.1750.10, 1 hit
3.30.300.180, 1 hit
HAMAPiMF_00377 DnaA_bact, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR001957 Chromosome_initiator_DnaA
IPR020591 Chromosome_initiator_DnaA-like
IPR018312 Chromosome_initiator_DnaA_CS
IPR013317 DnaA
IPR013159 DnaA_C
IPR024633 DnaA_N_dom
IPR038454 DnaA_N_sf
IPR027417 P-loop_NTPase
IPR010921 Trp_repressor/repl_initiator
PANTHERiPTHR30050:SF2 PTHR30050:SF2, 1 hit
PfamiView protein in Pfam
PF00308 Bac_DnaA, 1 hit
PF08299 Bac_DnaA_C, 1 hit
PF11638 DnaA_N, 1 hit
PRINTSiPR00051 DNAA
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00760 Bac_DnaA_C, 1 hit
SUPFAMiSSF48295 SSF48295, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00362 DnaA, 1 hit
PROSITEiView protein in PROSITE
PS01008 DNAA, 1 hit

Sequencei

Sequence statusi: Complete.

D9RUT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVSPKNLWD SCLQLIKENV TEQQFDTWFR PIVLQSYKPA SKTLLVQVPS
60 70 80 90 100
QFVYEYLEGH YVDLLRKVLT RVFGQGVQLT YRVMVDQENH LSQDLEQDTV
110 120 130 140 150
EDISSQRPTA RANQSPTVLD TVPQDLDSQL DPHKSFSNYV EGDSNKLPRS
160 170 180 190 200
IGLSIAEHPN TTQFNPMFIY GPSGCGKTHL VNAIGLKAKQ LYPQKRVLYV
210 220 230 240 250
SARLFQVQYT DSVRQNTTND FINFYQTIDI LIVDDIQEWV TATKTQDTFF
260 270 280 290 300
HIFNHLFRNG KRIILASDRP PVDLKGMNDR LLTRFSCGLI AELEKPNVQL
310 320 330 340 350
CVDILHSKIK RDGLNIPEDV VRFIAETANG SVRDLQGVIN SLLAYSVVYN
360 370 380 390 400
SNIDMRLAER VIKRAVKIDD EPLTIDDILD KVCTHYNVTM SAVNSRSRKK
410 420 430 440 450
DIVMARQVSM YMAQKYTKMP ASRIGKLVGN RDHSTVIHSC SKIEDRLKVD
460
KGFHAEIASI ENSFKLKA
Length:468
Mass (Da):53,375
Last modified:October 5, 2010 - v1
Checksum:i63FAA612399DFB4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002123 Genomic DNA Translation: ADK96742.1
RefSeqiWP_013265222.1, NC_014371.1

Genome annotation databases

EnsemblBacteriaiADK96742; ADK96742; HMPREF0659_A6416
GeneIDi9498194
KEGGipmz:HMPREF0659_A6416
PATRICifig|553174.6.peg.1396

Similar proteinsi

Entry informationi

Entry nameiD9RUT9_PREMB
AccessioniPrimary (citable) accession number: D9RUT9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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