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Protein

Alanine racemase

Gene

Closa_1587

Organism
Clostridium saccharolyticum (strain ATCC 35040 / DSM 2544 / NRCC 2533 / WM1)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei38 – 381Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei135 – 1351SubstrateUniRule annotation
Active sitei266 – 2661Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei314 – 3141Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciCSAC610130:GHTP-1640-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Closa_1587Imported
OrganismiClostridium saccharolyticum (strain ATCC 35040 / DSM 2544 / NRCC 2533 / WM1)Imported
Taxonomic identifieri610130 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
ProteomesiUP000001662: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei38 – 381N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD9RAA6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiWKGGAAI.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D9RAA6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLYSRVYET VDLDAIRHNM EAMKANLKDG TRMIGVVKSD GYGHGAVPVA
60 70 80 90 100
WAIDPYVWGY AVATVEEGVI LRKHGIRKPI LVLGVVPYEG YGLLVEHGIS
110 120 130 140 150
SAVFQLKRAE RLSSLAVREG KKAVIHLVLD TGMSRIGYPV TEEAAKEAAT
160 170 180 190 200
ICGLPGIEVE GLFTHFAKAD ERDKKATDHQ LEQYQKFVAM LADRGITIPM
210 220 230 240 250
LHCSNSAGIL DLQRANLHAV RAGISIYGIY PSGEVDRDTV KLRPAMELKS
260 270 280 290 300
FISYVKKIGP GTSVSYGGTF TADREMTVAT VPVGYGDGYP RNLSGKGEVL
310 320 330 340 350
IRGQRARILG RVCMDQFMVD VTGIHEAEEE DEVVLIGRQG KEEITVEDLA
360 370 380 390
MAGGGFHYEI VCDIGKRVPR IYLEDGRVIG TKDYFNDCYK GFCRV
Length:395
Mass (Da):43,450
Last modified:October 5, 2010 - v1
Checksum:i862F1266793611E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002109 Genomic DNA. Translation: ADL04184.1.
RefSeqiWP_013272275.1. NC_014376.1.
YP_003821807.1. NC_014376.1.

Genome annotation databases

EnsemblBacteriaiADL04184; ADL04184; Closa_1587.
GeneIDi9506877.
KEGGicsh:Closa_1587.
PATRICi42264680. VBICloSac91065_1719.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002109 Genomic DNA. Translation: ADL04184.1.
RefSeqiWP_013272275.1. NC_014376.1.
YP_003821807.1. NC_014376.1.

3D structure databases

ProteinModelPortaliD9RAA6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADL04184; ADL04184; Closa_1587.
GeneIDi9506877.
KEGGicsh:Closa_1587.
PATRICi42264680. VBICloSac91065_1719.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.
OMAiWKGGAAI.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciCSAC610130:GHTP-1640-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35040 / DSM 2544 / NRCC 2533 / WM1Imported.

Entry informationi

Entry nameiD9RAA6_CLOSW
AccessioniPrimary (citable) accession number: D9RAA6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: February 4, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.