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D9R399

- D9R399_CLOSW

UniProt

D9R399 - D9R399_CLOSW

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Protein
Thymidine kinase
Gene
tdk, Closa_2271
Organism
Clostridium saccharolyticum (strain ATCC 35040 / DSM 2544 / NRCC 2533 / WM1)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei83 – 831Proton acceptor By similarityUniRule annotation
Metal bindingi140 – 1401Zinc By similarityUniRule annotation
Metal bindingi142 – 1421Zinc By similarityUniRule annotation
Metal bindingi177 – 1771Zinc By similarityUniRule annotation
Metal bindingi180 – 1801Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi82 – 854ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciCSAC610130:GHTP-2331-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Closa_2271Imported
OrganismiClostridium saccharolyticum (strain ATCC 35040 / DSM 2544 / NRCC 2533 / WM1)Imported
Taxonomic identifieri610130 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
ProteomesiUP000001662: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000076391.
KOiK00857.
OMAiELKTVCH.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D9R399-1 [UniParc]FASTAAdd to Basket

« Hide

MAKLYFRYGA MGSSKTANAL MTRYNYMEKG KKVLLVKPDI ETRDGRKKIK    50
SRIGLEADCI LWSEFKNYDF KFINNLDAVI VDEVQFLSEA DIDQLSNIVD 100
EYHIPVFCYG LRIDFTSHLF SGSKRLMELA DEIEELKTVC WCGNHANMNA 150
RIDENGNIVR TGQQVSMGAN DKYVSLCRKH YKEGKIKQ 188
Length:188
Mass (Da):21,670
Last modified:October 5, 2010 - v1
Checksum:iCC098E99EE759E61
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002109 Genomic DNA. Translation: ADL04848.1.
RefSeqiYP_003822471.1. NC_014376.1.

Genome annotation databases

EnsemblBacteriaiADL04848; ADL04848; Closa_2271.
GeneIDi9507569.
KEGGicsh:Closa_2271.
PATRICi42266164. VBICloSac91065_2456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002109 Genomic DNA. Translation: ADL04848.1 .
RefSeqi YP_003822471.1. NC_014376.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADL04848 ; ADL04848 ; Closa_2271 .
GeneIDi 9507569.
KEGGi csh:Closa_2271.
PATRICi 42266164. VBICloSac91065_2456.

Phylogenomic databases

HOGENOMi HOG000076391.
KOi K00857.
OMAi ELKTVCH.

Enzyme and pathway databases

BioCyci CSAC610130:GHTP-2331-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35040 / DSM 2544 / NRCC 2533 / WM1.

Entry informationi

Entry nameiD9R399_CLOSW
AccessioniPrimary (citable) accession number: D9R399
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 26 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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