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Protein

Thymidine kinase

Gene

tdk

Organism
Clostridium saccharolyticum (strain ATCC 35040 / DSM 2544 / NRCC 2533 / WM1)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei83Proton acceptorUniRule annotation1
Metal bindingi140ZincUniRule annotation1
Metal bindingi142ZincUniRule annotation1
Metal bindingi177ZincUniRule annotation1
Metal bindingi180ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi82 – 85ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Closa_2271Imported
OrganismiClostridium saccharolyticum (strain ATCC 35040 / DSM 2544 / NRCC 2533 / WM1)Imported
Taxonomic identifieri610130 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaClostridialesLachnospiraceae
Proteomesi
  • UP000001662 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi610130.Closa_2271.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107SV9. Bacteria.
COG1435. LUCA.
HOGENOMiHOG000076391.
KOiK00857.
OMAiKEQFGWI.
OrthoDBiPOG091H0659.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiView protein in Pfam
PF00265. TK. 1 hit.
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS00603. TK_CELLULAR_TYPE. 1 hit.

Sequencei

Sequence statusi: Complete.

D9R399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLYFRYGA MGSSKTANAL MTRYNYMEKG KKVLLVKPDI ETRDGRKKIK
60 70 80 90 100
SRIGLEADCI LWSEFKNYDF KFINNLDAVI VDEVQFLSEA DIDQLSNIVD
110 120 130 140 150
EYHIPVFCYG LRIDFTSHLF SGSKRLMELA DEIEELKTVC WCGNHANMNA
160 170 180
RIDENGNIVR TGQQVSMGAN DKYVSLCRKH YKEGKIKQ
Length:188
Mass (Da):21,670
Last modified:October 5, 2010 - v1
Checksum:iCC098E99EE759E61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002109 Genomic DNA. Translation: ADL04848.1.
RefSeqiWP_013272934.1. NC_014376.1.

Genome annotation databases

EnsemblBacteriaiADL04848; ADL04848; Closa_2271.
KEGGicsh:Closa_2271.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiD9R399_CLOSW
AccessioniPrimary (citable) accession number: D9R399
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: July 5, 2017
This is version 46 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported