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D9QPU9

- D9QPU9_ACEAZ

UniProt

D9QPU9 - D9QPU9_ACEAZ

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Protein
3-oxoacyl-[acyl-carrier-protein] synthase 3
Gene
fabH, Acear_1013
Organism
Acetohalobium arabaticum (strain ATCC 49924 / DSM 5501 / Z-7288)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids By similarity.UniRule annotation

Catalytic activityi

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171 By similarityUniRule annotation
Active sitei256 – 2561 By similarityUniRule annotation
Active sitei286 – 2861 By similarityUniRule annotation

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
  2. beta-ketoacyl-acyl-carrier-protein synthase III activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

Fatty acid biosynthesisUniRule annotationSAAS annotations, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciAARA574087:GHPK-1080-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3UniRule annotation (EC:2.3.1.180UniRule annotation)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase III
Beta-ketoacyl-ACP synthase III
Gene namesi
Name:fabHUniRule annotation
Ordered Locus Names:Acear_1013Imported
OrganismiAcetohalobium arabaticum (strain ATCC 49924 / DSM 5501 / Z-7288)Imported
Taxonomic identifieri574087 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalobacteroidaceaeAcetohalobium
ProteomesiUP000001661: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliD9QPU9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni257 – 2615ACP-binding By similarityUniRule annotation

Domaini

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH By similarity.UniRule annotation

Sequence similaritiesi

Belongs to the FabH family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246676.
KOiK00648.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
HAMAPiMF_01815. FabH.
InterProiIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 1 hit.
TIGRFAMsiTIGR00747. fabH. 1 hit.

Sequencei

Sequence statusi: Complete.

D9QPU9-1 [UniParc]FASTAAdd to Basket

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MSKELRRAGI TGVGSYAPDK VLTNRDLEEM VDTSDEWIKS RTGIQERRIA    50
KEETTTSDLA YKAAEAALDD ADLAPEELDL ILVATVTPDM VFPATGCLLQ 100
DRLNATDAAA FDLEAGCSGF VYGISVATQF VRTGAYDNVL VIGAETLSKI 150
INWEDRNTCV LFGDGAGAAV IQPVESRGIL STVLGSDGSG GDVLQIPAGG 200
SKQPASLETV ENNLHCIQME GNAVFKFAVR AMGKGAVEAL NEAGLEKEDV 250
DFLIPHQANI RIIDGAAKRL NLSDDEVFVN LDKYGNTSAA SIPIALDEAV 300
EAGKIHSGDR VVIVGFGAGL TWAASVIEWS 330
Length:330
Mass (Da):34,949
Last modified:October 5, 2010 - v1
Checksum:i728EB725764CFF67
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002105 Genomic DNA. Translation: ADL12540.1.
RefSeqiWP_013277986.1. NC_014378.1.
YP_003827605.1. NC_014378.1.

Genome annotation databases

EnsemblBacteriaiADL12540; ADL12540; Acear_1013.
GeneIDi9513055.
KEGGiaar:Acear_1013.
PATRICi42136231. VBIAceAra30843_1040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002105 Genomic DNA. Translation: ADL12540.1 .
RefSeqi WP_013277986.1. NC_014378.1.
YP_003827605.1. NC_014378.1.

3D structure databases

ProteinModelPortali D9QPU9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADL12540 ; ADL12540 ; Acear_1013 .
GeneIDi 9513055.
KEGGi aar:Acear_1013.
PATRICi 42136231. VBIAceAra30843_1040.

Phylogenomic databases

HOGENOMi HOG000246676.
KOi K00648.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci AARA574087:GHPK-1080-MONOMER.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
HAMAPi MF_01815. FabH.
InterProi IPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 1 hit.
TIGRFAMsi TIGR00747. fabH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49924 / DSM 5501 / Z-7288.

Entry informationi

Entry nameiD9QPU9_ACEAZ
AccessioniPrimary (citable) accession number: D9QPU9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzymeUniRule annotationSAAS annotations

External Data

Dasty 3

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