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D9QPU9

- D9QPU9_ACEAZ

UniProt

D9QPU9 - D9QPU9_ACEAZ

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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 3

Gene

fabH

Organism
Acetohalobium arabaticum (strain ATCC 49924 / DSM 5501 / Z-7288)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.UniRule annotation

Catalytic activityi

Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO2.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei117 – 1171UniRule annotation
Active sitei256 – 2561UniRule annotation
Active sitei286 – 2861UniRule annotation

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: InterPro
  2. beta-ketoacyl-acyl-carrier-protein synthase III activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Fatty acid biosynthesisUniRule annotationSAAS annotation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciAARA574087:GHPK-1080-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 3UniRule annotation (EC:2.3.1.180UniRule annotation)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase IIIUniRule annotation
Beta-ketoacyl-ACP synthase IIIUniRule annotation
Gene namesi
Name:fabHUniRule annotation
Ordered Locus Names:Acear_1013Imported
OrganismiAcetohalobium arabaticum (strain ATCC 49924 / DSM 5501 / Z-7288)Imported
Taxonomic identifieri574087 [NCBI]
Taxonomic lineageiBacteriaFirmicutesClostridiaHalanaerobialesHalobacteroidaceaeAcetohalobium
ProteomesiUP000001661: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD9QPU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni257 – 2615ACP-bindingUniRule annotation

Domaini

The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.UniRule annotation

Sequence similaritiesi

Belongs to the FabH family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000246676.
KOiK00648.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
HAMAPiMF_01815. FabH.
InterProiIPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view]
SUPFAMiSSF53901. SSF53901. 1 hit.
TIGRFAMsiTIGR00747. fabH. 1 hit.

Sequencei

Sequence statusi: Complete.

D9QPU9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKELRRAGI TGVGSYAPDK VLTNRDLEEM VDTSDEWIKS RTGIQERRIA
60 70 80 90 100
KEETTTSDLA YKAAEAALDD ADLAPEELDL ILVATVTPDM VFPATGCLLQ
110 120 130 140 150
DRLNATDAAA FDLEAGCSGF VYGISVATQF VRTGAYDNVL VIGAETLSKI
160 170 180 190 200
INWEDRNTCV LFGDGAGAAV IQPVESRGIL STVLGSDGSG GDVLQIPAGG
210 220 230 240 250
SKQPASLETV ENNLHCIQME GNAVFKFAVR AMGKGAVEAL NEAGLEKEDV
260 270 280 290 300
DFLIPHQANI RIIDGAAKRL NLSDDEVFVN LDKYGNTSAA SIPIALDEAV
310 320 330
EAGKIHSGDR VVIVGFGAGL TWAASVIEWS
Length:330
Mass (Da):34,949
Last modified:October 5, 2010 - v1
Checksum:i728EB725764CFF67
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002105 Genomic DNA. Translation: ADL12540.1.
RefSeqiYP_003827605.1. NC_014378.1.

Genome annotation databases

EnsemblBacteriaiADL12540; ADL12540; Acear_1013.
GeneIDi9513055.
KEGGiaar:Acear_1013.
PATRICi42136231. VBIAceAra30843_1040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002105 Genomic DNA. Translation: ADL12540.1 .
RefSeqi YP_003827605.1. NC_014378.1.

3D structure databases

ProteinModelPortali D9QPU9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADL12540 ; ADL12540 ; Acear_1013 .
GeneIDi 9513055.
KEGGi aar:Acear_1013.
PATRICi 42136231. VBIAceAra30843_1040.

Phylogenomic databases

HOGENOMi HOG000246676.
KOi K00648.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci AARA574087:GHPK-1080-MONOMER.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
HAMAPi MF_01815. FabH.
InterProi IPR013751. ACP_syn_III.
IPR013747. ACP_syn_III_C.
IPR004655. FabH_synth.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF08545. ACP_syn_III. 1 hit.
PF08541. ACP_syn_III_C. 1 hit.
[Graphical view ]
SUPFAMi SSF53901. SSF53901. 1 hit.
TIGRFAMsi TIGR00747. fabH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 49924 / DSM 5501 / Z-7288Imported.

Entry informationi

Entry nameiD9QPU9_ACEAZ
AccessioniPrimary (citable) accession number: D9QPU9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 26, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzymeUniRule annotationSAAS annotation, Reference proteomeImported

External Data

Dasty 3