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Protein

Chromosomal replication initiator protein DnaA

Gene

dnaA

Organism
Corynebacterium pseudotuberculosis (strain C231)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.UniRule annotationSAAS annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi298 – 305ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotationSAAS annotation
Biological processDNA replicationUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosomal replication initiator protein DnaAUniRule annotation
Gene namesi
Name:dnaAUniRule annotationImported
Ordered Locus Names:CpC231_0001Imported
OrganismiCorynebacterium pseudotuberculosis (strain C231)Imported
Taxonomic identifieri681645 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000276 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini290 – 418AAAInterPro annotationAdd BLAST129
Domaini507 – 576Bac_DnaA_CInterPro annotationAdd BLAST70

Sequence similaritiesi

Belongs to the DnaA family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000235658.
KOiK02313.
OMAiREFNPLF.

Family and domain databases

CDDicd06571. Bac_DnaA_C. 1 hit.
Gene3Di1.10.1750.10. 1 hit.
HAMAPiMF_00377. DnaA_bact. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR001957. Chromosome_initiator_DnaA.
IPR020591. Chromosome_initiator_DnaA-like.
IPR018312. Chromosome_initiator_DnaA_CS.
IPR013317. DnaA.
IPR013159. DnaA_C.
IPR027417. P-loop_NTPase.
IPR010921. Trp_repressor/repl_initiator.
PANTHERiPTHR30050:SF2. PTHR30050:SF2. 1 hit.
PfamiView protein in Pfam
PF00308. Bac_DnaA. 1 hit.
PF08299. Bac_DnaA_C. 1 hit.
PRINTSiPR00051. DNAA.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00760. Bac_DnaA_C. 1 hit.
SUPFAMiSSF48295. SSF48295. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00362. DnaA. 1 hit.
PROSITEiView protein in PROSITE
PS01008. DNAA. 1 hit.

Sequencei

Sequence statusi: Complete.

D9QD56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEAPSTWNE RWQEVTNELL SQSQDPESGI SITRQQSAYL RLVKPVAFVE
60 70 80 90 100
GIAVLSVPHA RAKKEIETTL GPVITEVLSR RLGRQYSLAV SVHAPEENPE
110 120 130 140 150
VSSATPDAVS YYQEQSAVSG QYGATSANAD FQNQQSTIYR KPQESQYPVT
160 170 180 190 200
FGASSYGNEK YQENSQDQGI SHHPYGFNEA QRIASSASHA VPQSGSELLH
210 220 230 240 250
DPVHTRRTDA ALDQNYPGNT GGWRTEHIQE PMPTEQIPSG TPRTREQPSF
260 270 280 290 300
NPDRALALNP HYTFDSYVVS DSNKLPCSAA IAVAEKPARA YNPLFIWGDS
310 320 330 340 350
GLGKTHLMHA VGNYAQYLNP RLRIKYVSSE EFTNEYINSV RDDRQEAFKR
360 370 380 390 400
KYRELDILMV DDIQFLQGKE GTQEEFFHTF NALYQANKQI VLSSDRPPKQ
410 420 430 440 450
LTTLEDRLRT RFQAGLIADI YPPDLETRIA ILMKKAASES IVADREAIEL
460 470 480 490 500
IASRFNTSIR ELEGAFIRVS AYASLMSPDK GKHRIDLRIA EKALEDMMPE
510 520 530 540 550
QANEEITATT ILAATAEYFE MDVNALKGSG KTRAVAHARQ LAMYLCRELT
560 570 580 590 600
DLSLPKIGEQ FGGKDHTTVM YADRKIRKEI TEKKETYDEI QLLTQQIKSS

SRG
Length:603
Mass (Da):67,697
Last modified:October 5, 2010 - v1
Checksum:i7B27FEDE0A92A00C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001829 Genomic DNA. Translation: ADL09500.1.
RefSeqiWP_014400874.1. NC_017301.1.

Genome annotation databases

EnsemblBacteriaiADL09500; ADL09500; CpC231_0001.
GeneIDi12298869.
KEGGicpq:CpC231_0001.
PATRICifig|681645.3.peg.1.

Similar proteinsi

Entry informationi

Entry nameiD9QD56_CORP2
AccessioniPrimary (citable) accession number: D9QD56
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: October 25, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported