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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Corynebacterium pseudotuberculosis (strain C231)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi313Magnesium or manganese 1UniRule annotation1
Metal bindingi325Magnesium or manganese 1UniRule annotation1
Metal bindingi325Magnesium or manganese 2UniRule annotation1
Metal bindingi327Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotation
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotationImported
Ordered Locus Names:CpC231_0914Imported
OrganismiCorynebacterium pseudotuberculosis (strain C231)Imported
Taxonomic identifieri681645 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesCorynebacteriaceaeCorynebacterium
Proteomesi
  • UP000000276 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD9QA17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini154 – 358ATP-graspInterPro annotationAdd BLAST205

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000011593.
KOiK01921.
OMAiYETKYTE.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

D9QA17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCVVTQKPSP NPRVRVAVVY GGQSSEHSVS CVSAGAIMSH LDPQKYEVFP
60 70 80 90 100
VGITRDGVWT VGESDATKLR TVDRVMPEVE FVREVKLSVN PRSAGEFRYE
110 120 130 140 150
DGTLYAQADV IFPALHGRFG EDGTIQGMFE LSGIPYVGTG VLSSACGMDK
160 170 180 190 200
EYTKKLLAAE GLPVGKEVIL RGDETLTESD KQMLGLPVFV KPARGGSSIG
210 220 230 240 250
ISRVIEWDDF DAALTLAREH DTKVIVEAEI KGVEVECGVL ERADGSLIAS
260 270 280 290 300
VPAQLEDVDE GEEGFYGFDT KYLDNIVTAT IPAPFDQQTI ALIQSLSLEA
310 320 330 340 350
FQALNCRGLS RVDFFVTDQG PVLNEVNTMP GFTPISMYPQ VFEATGIGYA
360
ELLSHLIDQA LAQ
Length:363
Mass (Da):39,320
Last modified:October 5, 2010 - v1
Checksum:i07125E0F62D5499D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001829 Genomic DNA. Translation: ADL10393.1.
RefSeqiWP_013241771.1. NC_017301.1.

Genome annotation databases

EnsemblBacteriaiADL10393; ADL10393; CpC231_0914.
GeneIDi12299327.
KEGGicpq:CpC231_0914.
PATRICifig|681645.3.peg.953.

Similar proteinsi

Entry informationi

Entry nameiD9QA17_CORP2
AccessioniPrimary (citable) accession number: D9QA17
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: September 27, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported