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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Acidilobus saccharovorans (strain DSM 16705 / JCM 18335 / VKM B-2471 / 345-15)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathway:igluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathway:iglycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpiA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91SubstrateUniRule annotation
Binding sitei11 – 111SubstrateUniRule annotation
Active sitei93 – 931ElectrophileUniRule annotation
Active sitei141 – 1411Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationImported

Keywords - Biological processi

GluconeogenesisUniRule annotation, GlycolysisUniRule annotation, Pentose shuntUniRule annotation

Enzyme and pathway databases

BioCyciASAC666510:GH9G-1274-MONOMER.
UniPathwayiUPA00109; UER00189.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
Ordered Locus Names:ASAC_1230Imported
OrganismiAcidilobus saccharovorans (strain DSM 16705 / JCM 18335 / VKM B-2471 / 345-15)Imported
Taxonomic identifieri666510 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiAcidilobalesAcidilobaceaeAcidilobus
ProteomesiUP000000346 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi666510.ASAC_1230.

Structurei

3D structure databases

ProteinModelPortaliD9Q2U7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223030.
KOiK01803.
OMAiETWAQHV.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_A. TIM_A.
InterProiIPR013785. Aldolase_TIM.
IPR008867. ThiG.
IPR000652. Triosephosphate_isomerase.
IPR022891. Triosephosphate_isomerase_arc.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF05690. ThiG. 1 hit.
PF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
PROSITEiPS51440. TIM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D9Q2U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLVFAVNF KAYETAFNEK SLEIAREASK ASSRYGNVRV ILIVPAAIAS
60 70 80 90 100
KVLQIYDDVY IEHADPVDYG AYTGYLPAKA ARLLGVRGIL VNHSEHKMIY
110 120 130 140 150
RDVAKVVETA SKDGIETMAC ADTPGEAAGL AYLRPTYIAI EPPELIGTGV
160 170 180 190 200
SVSKARPEVI TEGVKAVKAV ADIPVLAGAG ITYREDVVRA VQLGASGILL
210 220
ASAVMKAADP DKALSEFVDA LSSVA
Length:225
Mass (Da):23,851
Last modified:October 5, 2010 - v1
Checksum:i7B826A75E692D6F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001742 Genomic DNA. Translation: ADL19635.1.
RefSeqiWP_013267147.1. NC_014374.1.
YP_003816666.1. NC_014374.1.

Genome annotation databases

EnsemblBacteriaiADL19635; ADL19635; ASAC_1230.
GeneIDi9499485.
KEGGiasc:ASAC_1230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001742 Genomic DNA. Translation: ADL19635.1.
RefSeqiWP_013267147.1. NC_014374.1.
YP_003816666.1. NC_014374.1.

3D structure databases

ProteinModelPortaliD9Q2U7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi666510.ASAC_1230.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiADL19635; ADL19635; ASAC_1230.
GeneIDi9499485.
KEGGiasc:ASAC_1230.

Phylogenomic databases

HOGENOMiHOG000223030.
KOiK01803.
OMAiETWAQHV.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00189.
UPA00138.
BioCyciASAC666510:GH9G-1274-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_A. TIM_A.
InterProiIPR013785. Aldolase_TIM.
IPR008867. ThiG.
IPR000652. Triosephosphate_isomerase.
IPR022891. Triosephosphate_isomerase_arc.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF05690. ThiG. 1 hit.
PF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
PROSITEiPS51440. TIM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome sequence of the crenarchaeon Acidilobus saccharovorans supports a new order, Acidilobales, and suggests an important ecological role in terrestrial acidic hot springs."
    Mardanov A.V., Svetlitchnyi V.A., Beletsky A.V., Prokofeva M.I., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
    Appl. Environ. Microbiol. 76:5652-5657(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16705 / JCM 18335 / VKM B-2471 / 345-15Imported.

Entry informationi

Entry nameiD9Q2U7_ACIS3
AccessioniPrimary (citable) accession number: D9Q2U7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: June 24, 2015
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.