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D9Q2U7

- D9Q2U7_ACIS3

UniProt

D9Q2U7 - D9Q2U7_ACIS3

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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Acidilobus saccharovorans (strain DSM 16705 / VKM B-2471 / 345-15)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91SubstrateUniRule annotation
Binding sitei11 – 111SubstrateUniRule annotation
Active sitei93 – 931ElectrophileUniRule annotation
Active sitei141 – 1411Proton acceptorUniRule annotation

GO - Molecular functioni

  1. 2-iminoacetate synthase activity Source: InterPro
  2. triose-phosphate isomerase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. gluconeogenesis Source: UniProtKB-HAMAP
  2. glycolytic process Source: UniProtKB-HAMAP
  3. pentose-phosphate shunt Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationImported

Keywords - Biological processi

GluconeogenesisUniRule annotation, GlycolysisUniRule annotation, Pentose shuntUniRule annotation

Enzyme and pathway databases

BioCyciASAC666510:GH9G-1274-MONOMER.
UniPathwayiUPA00109; UER00189.
UPA00138.

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
Ordered Locus Names:ASAC_1230Imported
OrganismiAcidilobus saccharovorans (strain DSM 16705 / VKM B-2471 / 345-15)Imported
Taxonomic identifieri666510 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiAcidilobalesAcidilobaceaeAcidilobus
ProteomesiUP000000346: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD9Q2U7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000223030.
KOiK01803.
OMAiETWAQHV.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00147_A. TIM_A.
InterProiIPR013785. Aldolase_TIM.
IPR008867. ThiG.
IPR000652. Triosephosphate_isomerase.
IPR022891. Triosephosphate_isomerase_arc.
[Graphical view]
PANTHERiPTHR21139. PTHR21139. 1 hit.
PfamiPF05690. ThiG. 1 hit.
PF00121. TIM. 1 hit.
[Graphical view]
SUPFAMiSSF51351. SSF51351. 1 hit.
PROSITEiPS51440. TIM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D9Q2U7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPRLVFAVNF KAYETAFNEK SLEIAREASK ASSRYGNVRV ILIVPAAIAS
60 70 80 90 100
KVLQIYDDVY IEHADPVDYG AYTGYLPAKA ARLLGVRGIL VNHSEHKMIY
110 120 130 140 150
RDVAKVVETA SKDGIETMAC ADTPGEAAGL AYLRPTYIAI EPPELIGTGV
160 170 180 190 200
SVSKARPEVI TEGVKAVKAV ADIPVLAGAG ITYREDVVRA VQLGASGILL
210 220
ASAVMKAADP DKALSEFVDA LSSVA
Length:225
Mass (Da):23,851
Last modified:October 5, 2010 - v1
Checksum:i7B826A75E692D6F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001742 Genomic DNA. Translation: ADL19635.1.
RefSeqiYP_003816666.1. NC_014374.1.

Genome annotation databases

EnsemblBacteriaiADL19635; ADL19635; ASAC_1230.
GeneIDi9499485.
KEGGiasc:ASAC_1230.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001742 Genomic DNA. Translation: ADL19635.1 .
RefSeqi YP_003816666.1. NC_014374.1.

3D structure databases

ProteinModelPortali D9Q2U7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADL19635 ; ADL19635 ; ASAC_1230 .
GeneIDi 9499485.
KEGGi asc:ASAC_1230.

Phylogenomic databases

HOGENOMi HOG000223030.
KOi K01803.
OMAi ETWAQHV.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00189 .
UPA00138 .
BioCyci ASAC666510:GH9G-1274-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00147_A. TIM_A.
InterProi IPR013785. Aldolase_TIM.
IPR008867. ThiG.
IPR000652. Triosephosphate_isomerase.
IPR022891. Triosephosphate_isomerase_arc.
[Graphical view ]
PANTHERi PTHR21139. PTHR21139. 1 hit.
Pfami PF05690. ThiG. 1 hit.
PF00121. TIM. 1 hit.
[Graphical view ]
SUPFAMi SSF51351. SSF51351. 1 hit.
PROSITEi PS51440. TIM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of the crenarchaeon Acidilobus saccharovorans supports a new order, Acidilobales, and suggests an important ecological role in terrestrial acidic hot springs."
    Mardanov A.V., Svetlitchnyi V.A., Beletsky A.V., Prokofeva M.I., Bonch-Osmolovskaya E.A., Ravin N.V., Skryabin K.G.
    Appl. Environ. Microbiol. 76:5652-5657(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 16705 / VKM B-2471 / 345-15Imported.

Entry informationi

Entry nameiD9Q2U7_ACIS3
AccessioniPrimary (citable) accession number: D9Q2U7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3