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Protein

Triosephosphate isomerase

Gene

tpiA

Organism
Acidilobus saccharovorans (strain DSM 16705 / JCM 18335 / VKM B-2471 / 345-15)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).UniRule annotation

Catalytic activityi

D-glyceraldehyde 3-phosphate = glycerone phosphate.UniRule annotation

Pathwayi: gluconeogenesis

This protein is involved in the pathway gluconeogenesis, which is part of Carbohydrate biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway gluconeogenesis and in Carbohydrate biosynthesis.

Pathwayi: glycolysis

This protein is involved in step 1 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Triosephosphate isomerase (tpiA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate from glycerone phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei93ElectrophileUniRule annotation1
Active sitei141Proton acceptorUniRule annotation1
Binding sitei146Substrate; via carbonyl oxygenUniRule annotation1
Binding sitei180Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationImported
Biological processGluconeogenesisUniRule annotation, GlycolysisUniRule annotation

Enzyme and pathway databases

BioCyciASAC666510:G1GMD-1263-MONOMER
UniPathwayiUPA00109; UER00189
UPA00138

Names & Taxonomyi

Protein namesi
Recommended name:
Triosephosphate isomeraseUniRule annotation (EC:5.3.1.1UniRule annotation)
Short name:
TIMUniRule annotation
Short name:
TPIUniRule annotation
Alternative name(s):
Triose-phosphate isomeraseUniRule annotation
Gene namesi
Name:tpiAUniRule annotation
Ordered Locus Names:ASAC_1230Imported
OrganismiAcidilobus saccharovorans (strain DSM 16705 / JCM 18335 / VKM B-2471 / 345-15)Imported
Taxonomic identifieri666510 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiAcidilobalesAcidilobaceaeAcidilobus
Proteomesi
  • UP000000346 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer; dimer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi666510.ASAC_1230

Structurei

3D structure databases

ProteinModelPortaliD9Q2U7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 217ThiGInterPro annotationAdd BLAST56

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni9 – 11Substrate bindingUniRule annotation3
Regioni201 – 202Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the triosephosphate isomerase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01087 Archaea
COG0149 LUCA
HOGENOMiHOG000223030
KOiK01803
OMAiIPVYAQH
OrthoDBiPOG093Z0G5K

Family and domain databases

CDDicd00311 TIM, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00147_A TIM_A, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR033983 Thiazole_synthase_ThiG
IPR035990 TIM_sf
IPR000652 Triosephosphate_isomerase
IPR022891 Triosephosphate_isomerase_arc
PANTHERiPTHR21139 PTHR21139, 1 hit
PfamiView protein in Pfam
PF05690 ThiG, 1 hit
PF00121 TIM, 1 hit
SUPFAMiSSF51351 SSF51351, 1 hit
PROSITEiView protein in PROSITE
PS51440 TIM_2, 1 hit

Sequencei

Sequence statusi: Complete.

D9Q2U7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRLVFAVNF KAYETAFNEK SLEIAREASK ASSRYGNVRV ILIVPAAIAS
60 70 80 90 100
KVLQIYDDVY IEHADPVDYG AYTGYLPAKA ARLLGVRGIL VNHSEHKMIY
110 120 130 140 150
RDVAKVVETA SKDGIETMAC ADTPGEAAGL AYLRPTYIAI EPPELIGTGV
160 170 180 190 200
SVSKARPEVI TEGVKAVKAV ADIPVLAGAG ITYREDVVRA VQLGASGILL
210 220
ASAVMKAADP DKALSEFVDA LSSVA
Length:225
Mass (Da):23,851
Last modified:October 5, 2010 - v1
Checksum:i7B826A75E692D6F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001742 Genomic DNA Translation: ADL19635.1
RefSeqiWP_013267147.1, NC_014374.1

Genome annotation databases

EnsemblBacteriaiADL19635; ADL19635; ASAC_1230
GeneIDi9499485
KEGGiasc:ASAC_1230

Similar proteinsi

Entry informationi

Entry nameiD9Q2U7_ACIS3
AccessioniPrimary (citable) accession number: D9Q2U7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: April 25, 2018
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health