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D9PYF9

- D9PYF9_METTM

UniProt

D9PYF9 - D9PYF9_METTM

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Protein
Submitted name:

F420-reducing hydrogenase, subunit alpha

Gene

frhA

Organism
Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Unreviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. coenzyme F420 hydrogenase activity Source: UniProtKB-EC
  2. ferredoxin hydrogenase activity Source: InterPro
  3. flavin adenine dinucleotide binding Source: InterPro
  4. iron-sulfur cluster binding Source: InterPro
  5. nickel cation binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Ligandi

IronImported, MagnesiumImported, Metal-bindingUniRule annotationImported, NickelUniRule annotation

Enzyme and pathway databases

BioCyciMMAR79929:GH5J-1692-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
F420-reducing hydrogenase, subunit alphaImported (EC:1.12.98.1Imported)
Gene namesi
Name:frhAImported
Ordered Locus Names:MTBMA_c16860Imported
OrganismiMethanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)Imported
Taxonomic identifieri79929 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000000345: Chromosome

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZFSelectron microscopy4.00A1-405[»]
4CI0electron microscopy3.36A1-386[»]
4OMFX-ray1.71A1-405[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000004885.
KOiK00440.
OMAiHSINIEN.

Family and domain databases

Gene3Di1.10.645.10. 1 hit.
InterProiIPR017682. Coenz_F420_hydrogenase_asu.
IPR001501. Ni-dep_hyd_lsu.
IPR018194. Ni-dep_hyd_lsu_Ni_BS.
IPR029014. NiFe_Hase-like.
[Graphical view]
PfamiPF00374. NiFeSe_Hases. 3 hits.
[Graphical view]
SUPFAMiSSF56762. SSF56762. 1 hit.
TIGRFAMsiTIGR03295. frhA. 1 hit.
PROSITEiPS00507. NI_HGENASE_L_1. 1 hit.
PS00508. NI_HGENASE_L_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D9PYF9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSERIVISPT SRQEGHAELV MEVDDEGIVT KGRYFSITPV RGLEKMVTGK
60 70 80 90 100
APETAPVMVQ RICGVCPIPH TLASVEAIDD SLDIEVPKAG RLLRELTLAA
110 120 130 140 150
HHVNSHAIHH FLIAPDFVPE NLMADAINSV SEIRKNAQYV VDMVAGEGIH
160 170 180 190 200
PSDVRIGGMA DNITELARKR LYARLKQLKP KVNEHVELMI GLIEDKGLPE
210 220 230 240 250
GLGVHNQPTL ASHQIYGDRT KFDLDRFTEI MPESWYDDPE IAKRACSTIP
260 270 280 290 300
LYDGRNVEVG PRARMVEFQG FKERGVVAQH VARALEMKTA LSRAIEILDE
310 320 330 340 350
LDTSAPVRAD FDERGTGKLG IGAIEAPRGL DVHMAKVENG KIQFYSALVP
360 370 380 390 400
TTWNIPTMGP ATEGFHHEYG PHVIRAYDPC LSCATHVMVV DDEDKSVIKN

EMVKI
Length:405
Mass (Da):44,811
Last modified:October 5, 2010 - v1
Checksum:i1172C414E1ADFEBD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001710 Genomic DNA. Translation: ADL59257.1.
RefSeqiYP_003850570.1. NC_014408.1.

Genome annotation databases

EnsemblBacteriaiADL59257; ADL59257; MTBMA_c16860.
GeneIDi9705397.
KEGGimmg:MTBMA_c16860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001710 Genomic DNA. Translation: ADL59257.1 .
RefSeqi YP_003850570.1. NC_014408.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZFS electron microscopy 4.00 A 1-405 [» ]
4CI0 electron microscopy 3.36 A 1-386 [» ]
4OMF X-ray 1.71 A 1-405 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADL59257 ; ADL59257 ; MTBMA_c16860 .
GeneIDi 9705397.
KEGGi mmg:MTBMA_c16860.

Phylogenomic databases

HOGENOMi HOG000004885.
KOi K00440.
OMAi HSINIEN.

Enzyme and pathway databases

BioCyci MMAR79929:GH5J-1692-MONOMER.

Family and domain databases

Gene3Di 1.10.645.10. 1 hit.
InterProi IPR017682. Coenz_F420_hydrogenase_asu.
IPR001501. Ni-dep_hyd_lsu.
IPR018194. Ni-dep_hyd_lsu_Ni_BS.
IPR029014. NiFe_Hase-like.
[Graphical view ]
Pfami PF00374. NiFeSe_Hases. 3 hits.
[Graphical view ]
SUPFAMi SSF56762. SSF56762. 1 hit.
TIGRFAMsi TIGR03295. frhA. 1 hit.
PROSITEi PS00507. NI_HGENASE_L_1. 1 hit.
PS00508. NI_HGENASE_L_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Methanothermobacter marburgensis."
    Kaster A., Seedorf H., Goenrich M., Wiezer A., Liesegang H., Thauer R., Gottschalk G.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Marburg.
  2. "Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
    Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
    J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / MarburgImported.
  3. "De novo modeling of the F420-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy."
    Mills D.J., Vitt S., Strauss M., Shima S., Vonck J.
    Elife 2:e00218-e00218(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (4.00 ANGSTROMS).
  4. "Atomic model of the F420-reducing [NiFe] hydrogenase by electron cryo-microscopy using a direct electron detector."
    Allegretti M., Mills D.J., McMullan G., Kuhlbrandt W., Vonck J.
    Elife 3:e01963-e01963(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (3.36 ANGSTROMS) OF 1-386 IN COMPLEX WITH IRON, ACTIVE SITE.
  5. "The F420-reducing [NiFe]-hydrogenase complex from Methanothermobacter marburgensis, the first X-ray structure of a group 3 family member."
    Vitt S., Ma K., Warkentin E., Moll J., Pierik A.J., Shima S., Ermler U.
    J. Mol. Biol. 426:2813-2826(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.71 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.

Entry informationi

Entry nameiD9PYF9_METTM
AccessioniPrimary (citable) accession number: D9PYF9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 26, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3