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D9PYF9

- D9PYF9_METTM

UniProt

D9PYF9 - D9PYF9_METTM

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Protein
Submitted name: F420-reducing hydrogenase, subunit alpha
Gene
frhA, MTBMA_c16860
Organism
Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi44 – 441IronImported
Metal bindingi63 – 631NickelImported
Metal bindingi66 – 661NickelImported
Metal bindingi347 – 3471Iron; via carbonyl oxygenImported
Metal bindingi380 – 3801NickelImported
Metal bindingi383 – 3831NickelImported
Metal bindingi386 – 3861Iron; via tele nitrogenImported

GO - Molecular functioni

  1. coenzyme F420 hydrogenase activity Source: UniProtKB-EC
  2. ferredoxin hydrogenase activity Source: InterPro
  3. flavin adenine dinucleotide binding Source: InterPro
  4. iron-sulfur cluster binding Source: InterPro
  5. nickel cation binding Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Ligandi

    IronImported, Metal-bindingUniRule annotationImported, NickelUniRule annotationImported

    Enzyme and pathway databases

    BioCyciMMAR79929:GH5J-1692-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    F420-reducing hydrogenase, subunit alphaImported (EC:1.12.98.1Imported)
    Gene namesi
    Name:frhAImported
    Ordered Locus Names:MTBMA_c16860Imported
    OrganismiMethanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)Imported
    Taxonomic identifieri79929 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000000345: Chromosome

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZFSelectron microscopy4.00A1-405[»]
    4CI0electron microscopy3.36A1-386[»]
    4OMFX-ray1.71A1-405[»]

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    HOGENOMiHOG000004885.
    KOiK00440.
    OMAiHSINIEN.

    Family and domain databases

    Gene3Di1.10.645.10. 1 hit.
    InterProiIPR017682. Coenz_F420_hydrogenase_asu.
    IPR001501. Ni-dep_hyd_lsu.
    IPR018194. Ni-dep_hyd_lsu_Ni_BS.
    IPR029014. NiFe_Hase-like.
    [Graphical view]
    PfamiPF00374. NiFeSe_Hases. 3 hits.
    [Graphical view]
    SUPFAMiSSF56762. SSF56762. 1 hit.
    TIGRFAMsiTIGR03295. frhA. 1 hit.
    PROSITEiPS00507. NI_HGENASE_L_1. 1 hit.
    PS00508. NI_HGENASE_L_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D9PYF9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSERIVISPT SRQEGHAELV MEVDDEGIVT KGRYFSITPV RGLEKMVTGK    50
    APETAPVMVQ RICGVCPIPH TLASVEAIDD SLDIEVPKAG RLLRELTLAA 100
    HHVNSHAIHH FLIAPDFVPE NLMADAINSV SEIRKNAQYV VDMVAGEGIH 150
    PSDVRIGGMA DNITELARKR LYARLKQLKP KVNEHVELMI GLIEDKGLPE 200
    GLGVHNQPTL ASHQIYGDRT KFDLDRFTEI MPESWYDDPE IAKRACSTIP 250
    LYDGRNVEVG PRARMVEFQG FKERGVVAQH VARALEMKTA LSRAIEILDE 300
    LDTSAPVRAD FDERGTGKLG IGAIEAPRGL DVHMAKVENG KIQFYSALVP 350
    TTWNIPTMGP ATEGFHHEYG PHVIRAYDPC LSCATHVMVV DDEDKSVIKN 400
    EMVKI 405
    Length:405
    Mass (Da):44,811
    Last modified:October 5, 2010 - v1
    Checksum:i1172C414E1ADFEBD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001710 Genomic DNA. Translation: ADL59257.1.
    RefSeqiYP_003850570.1. NC_014408.1.

    Genome annotation databases

    EnsemblBacteriaiADL59257; ADL59257; MTBMA_c16860.
    GeneIDi9705397.
    KEGGimmg:MTBMA_c16860.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001710 Genomic DNA. Translation: ADL59257.1 .
    RefSeqi YP_003850570.1. NC_014408.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZFS electron microscopy 4.00 A 1-405 [» ]
    4CI0 electron microscopy 3.36 A 1-386 [» ]
    4OMF X-ray 1.71 A 1-405 [» ]
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADL59257 ; ADL59257 ; MTBMA_c16860 .
    GeneIDi 9705397.
    KEGGi mmg:MTBMA_c16860.

    Phylogenomic databases

    HOGENOMi HOG000004885.
    KOi K00440.
    OMAi HSINIEN.

    Enzyme and pathway databases

    BioCyci MMAR79929:GH5J-1692-MONOMER.

    Family and domain databases

    Gene3Di 1.10.645.10. 1 hit.
    InterProi IPR017682. Coenz_F420_hydrogenase_asu.
    IPR001501. Ni-dep_hyd_lsu.
    IPR018194. Ni-dep_hyd_lsu_Ni_BS.
    IPR029014. NiFe_Hase-like.
    [Graphical view ]
    Pfami PF00374. NiFeSe_Hases. 3 hits.
    [Graphical view ]
    SUPFAMi SSF56762. SSF56762. 1 hit.
    TIGRFAMsi TIGR03295. frhA. 1 hit.
    PROSITEi PS00507. NI_HGENASE_L_1. 1 hit.
    PS00508. NI_HGENASE_L_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. "The genome sequence of Methanothermobacter marburgensis."
      Kaster A., Seedorf H., Goenrich M., Wiezer A., Liesegang H., Thauer R., Gottschalk G.
      Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Marburg.
    2. "Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
      Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
      J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
    3. "De novo modeling of the F420-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy."
      Mills D.J., Vitt S., Strauss M., Shima S., Vonck J.
      Elife 2:e00218-e00218(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY ELECTRON MICROSCOPY (4.00 ANGSTROMS).
    4. "Atomic model of the F420-reducing [NiFe] hydrogenase by electron cryo-microscopy using a direct electron detector."
      Allegretti M., Mills D.J., McMullan G., Kuhlbrandt W., Vonck J.
      Elife 3:e01963-e01963(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY ELECTRON MICROSCOPY (3.36 ANGSTROMS) OF 1-386 IN COMPLEX WITH IRON AND NICKEL.

    Entry informationi

    Entry nameiD9PYF9_METTM
    AccessioniPrimary (citable) accession number: D9PYF9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: September 3, 2014
    This is version 28 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome

    External Data

    Dasty 3

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