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D9PYF7

- D9PYF7_METTM

UniProt

D9PYF7 - D9PYF7_METTM

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Protein
Submitted name: F420-reducing hydrogenase, subunit gamma
Gene
frhG, MTBMA_c16840
Organism
Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi56 – 561Iron-sulfur (4Fe-4S) 1Imported
Metal bindingi56 – 561Iron-sulfur (4Fe-4S) 2
Metal bindingi57 – 571Iron-sulfur (4Fe-4S) 1Imported
Metal bindingi59 – 591Iron-sulfur (4Fe-4S) 2
Metal bindingi60 – 601Iron-sulfur (4Fe-4S) 1Imported
Metal bindingi131 – 1311Iron-sulfur (4Fe-4S) 1; via amide nitrogenImported
Metal bindingi132 – 1321Iron-sulfur (4Fe-4S) 1Imported
Metal bindingi171 – 1711Iron-sulfur (4Fe-4S) 1Imported
Metal bindingi220 – 2201Iron-sulfur (4Fe-4S) 4Imported
Metal bindingi223 – 2231Iron-sulfur (4Fe-4S) 4Imported
Metal bindingi224 – 2241Iron-sulfur (4Fe-4S) 4; via amide nitrogenImported
Metal bindingi224 – 2241Iron-sulfur (4Fe-4S) 5
Metal bindingi225 – 2251Iron-sulfur (4Fe-4S) 4Imported
Metal bindingi226 – 2261Iron-sulfur (4Fe-4S) 4Imported
Metal bindingi230 – 2301Iron-sulfur (4Fe-4S) 3Imported
Metal bindingi232 – 2321Iron-sulfur (4Fe-4S) 3Imported
Metal bindingi235 – 2351Iron-sulfur (4Fe-4S) 3Imported
Metal bindingi249 – 2491Iron-sulfur (4Fe-4S) 3Imported
Metal bindingi251 – 2511Iron-sulfur (4Fe-4S) 6
Metal bindingi252 – 2521Iron-sulfur (4Fe-4S) 3Imported
Metal bindingi255 – 2551Iron-sulfur (4Fe-4S) 3Imported
Metal bindingi255 – 2551Iron-sulfur (4Fe-4S) 6
Metal bindingi259 – 2591Iron-sulfur (4Fe-4S) 4Imported

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. coenzyme F420 hydrogenase activity Source: UniProtKB-EC
  3. flavin adenine dinucleotide binding Source: InterPro
  4. nickel cation binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

4Fe-4SImported, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciMMAR79929:GH5J-1690-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
F420-reducing hydrogenase, subunit gammaImported (EC:1.12.98.1Imported)
Gene namesi
Name:frhGImported
Ordered Locus Names:MTBMA_c16840Imported
OrganismiMethanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)Imported
Taxonomic identifieri79929 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000000345: Chromosome

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZFSelectron microscopy4.00B1-275[»]
4CI0electron microscopy3.36B1-275[»]
4OMFX-ray1.71G1-275[»]

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000236993.
KOiK00443.
OMAiCPPSPEI.

Family and domain databases

Gene3Di3.40.50.700. 1 hit.
InterProiIPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR017681. Coenz_F420_hydrogenase_gsu.
IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
[Graphical view]
PfamiPF13237. Fer4_10. 1 hit.
PF01058. Oxidored_q6. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03294. FrhG. 1 hit.
PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D9PYF7-1 [UniParc]FASTAAdd to Basket

« Hide

MSLIARIKRF LGLEAEAKRE EPEKEKSEPV GASKEEVEKV AEENAKPRIG    50
YIHLSGCTGD AMSLTENYDI LAELLTNMVD IVYGQTLVDL WEMPEMDLAL 100
VEGSVCLQDE HSLHELKELR EKAKLVCAFG SCAATGCFTR YSRGGQQAQP 150
SHESFVPIAD LIDVDLALPG CPPSPEIIAK TVVALLNNDM DYLQPMLDLA 200
GYTEACGCDL QTKVVNQGLC IGCGTCAMAC QTRALDMTNG RPELNSDRCI 250
KCGICYVQCP RSWWPEEQIK KELGL 275
Length:275
Mass (Da):30,238
Last modified:October 5, 2010 - v1
Checksum:i858E41DFB402030A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001710 Genomic DNA. Translation: ADL59255.1.
RefSeqiYP_003850568.1. NC_014408.1.

Genome annotation databases

EnsemblBacteriaiADL59255; ADL59255; MTBMA_c16840.
GeneIDi9705395.
KEGGimmg:MTBMA_c16840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001710 Genomic DNA. Translation: ADL59255.1 .
RefSeqi YP_003850568.1. NC_014408.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZFS electron microscopy 4.00 B 1-275 [» ]
4CI0 electron microscopy 3.36 B 1-275 [» ]
4OMF X-ray 1.71 G 1-275 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADL59255 ; ADL59255 ; MTBMA_c16840 .
GeneIDi 9705395.
KEGGi mmg:MTBMA_c16840.

Phylogenomic databases

HOGENOMi HOG000236993.
KOi K00443.
OMAi CPPSPEI.

Enzyme and pathway databases

BioCyci MMAR79929:GH5J-1690-MONOMER.

Family and domain databases

Gene3Di 3.40.50.700. 1 hit.
InterProi IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR017681. Coenz_F420_hydrogenase_gsu.
IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
[Graphical view ]
Pfami PF13237. Fer4_10. 1 hit.
PF01058. Oxidored_q6. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03294. FrhG. 1 hit.
PROSITEi PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Methanothermobacter marburgensis."
    Kaster A., Seedorf H., Goenrich M., Wiezer A., Liesegang H., Thauer R., Gottschalk G.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Marburg.
  2. "Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
    Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
    J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg.
  3. "De novo modeling of the F420-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy."
    Mills D.J., Vitt S., Strauss M., Shima S., Vonck J.
    Elife 2:e00218-e00218(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (4.00 ANGSTROMS) IN COMPLEX WITH IRON-SULFUR (4FE-4S).
  4. "Atomic model of the F420-reducing [NiFe] hydrogenase by electron cryo-microscopy using a direct electron detector."
    Allegretti M., Mills D.J., McMullan G., Kuhlbrandt W., Vonck J.
    Elife 3:e01963-e01963(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (3.36 ANGSTROMS) IN COMPLEX WITH IRON-SULFUR (4FE-4S).

Entry informationi

Entry nameiD9PYF7_METTM
AccessioniPrimary (citable) accession number: D9PYF7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: September 3, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome

External Data

Dasty 3

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