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D9PYF7

- D9PYF7_METTM

UniProt

D9PYF7 - D9PYF7_METTM

Protein
Submitted name:

F420-reducing hydrogenase, subunit gamma

Gene

frhG

Organism
Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (05 Oct 2010)
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi56 – 561Iron-sulfur (4Fe-4S) 2
    Metal bindingi56 – 561Iron-sulfur(4Fe-4S) 1Imported
    Metal bindingi56 – 561Iron-sulfur(4Fe-4S) 2Imported
    Metal bindingi57 – 571Iron-sulfur(4Fe-4S) 1Imported
    Metal bindingi59 – 591Iron-sulfur (4Fe-4S) 2
    Metal bindingi59 – 591Iron-sulfur(4Fe-4S) 2Imported
    Metal bindingi60 – 601Iron-sulfur(4Fe-4S) 1Imported
    Metal bindingi131 – 1311Iron-sulfur(4Fe-4S) 1; via amide nitrogenImported
    Metal bindingi132 – 1321Iron-sulfur(4Fe-4S) 1Imported
    Metal bindingi171 – 1711Iron-sulfur(4Fe-4S) 1Imported
    Metal bindingi220 – 2201Iron-sulfur(4Fe-4S) 4Imported
    Metal bindingi223 – 2231Iron-sulfur(4Fe-4S) 4Imported
    Metal bindingi224 – 2241Iron-sulfur (4Fe-4S) 5
    Metal bindingi224 – 2241Iron-sulfur(4Fe-4S) 4; via amide nitrogenImported
    Metal bindingi224 – 2241Iron-sulfur(4Fe-4S) 5Imported
    Metal bindingi225 – 2251Iron-sulfur(4Fe-4S) 4Imported
    Metal bindingi226 – 2261Iron-sulfur(4Fe-4S) 4Imported
    Metal bindingi230 – 2301Iron-sulfur(4Fe-4S) 3Imported
    Metal bindingi232 – 2321Iron-sulfur(4Fe-4S) 3Imported
    Metal bindingi235 – 2351Iron-sulfur(4Fe-4S) 3Imported
    Metal bindingi249 – 2491Iron-sulfur(4Fe-4S) 3Imported
    Metal bindingi251 – 2511Iron-sulfur (4Fe-4S) 6
    Metal bindingi251 – 2511Iron-sulfur(4Fe-4S) 7Imported
    Metal bindingi252 – 2521Iron-sulfur(4Fe-4S) 3Imported
    Metal bindingi255 – 2551Iron-sulfur (4Fe-4S) 6
    Metal bindingi255 – 2551Iron-sulfur(4Fe-4S) 3Imported
    Metal bindingi255 – 2551Iron-sulfur(4Fe-4S) 7Imported
    Metal bindingi259 – 2591Iron-sulfur(4Fe-4S) 4Imported

    GO - Molecular functioni

    1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
    2. coenzyme F420 hydrogenase activity Source: UniProtKB-EC
    3. flavin adenine dinucleotide binding Source: InterPro
    4. nickel cation binding Source: InterPro

    Keywords - Molecular functioni

    OxidoreductaseImported

    Keywords - Ligandi

    Metal-bindingImported

    Enzyme and pathway databases

    BioCyciMMAR79929:GH5J-1690-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    F420-reducing hydrogenase, subunit gammaImported (EC:1.12.98.1Imported)
    Gene namesi
    Name:frhGImported
    Ordered Locus Names:MTBMA_c16840Imported
    OrganismiMethanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)Imported
    Taxonomic identifieri79929 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
    ProteomesiUP000000345: Chromosome

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3ZFSelectron microscopy4.00B1-275[»]
    4CI0electron microscopy3.36B1-275[»]
    4OMFX-ray1.71G1-275[»]
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOGENOMiHOG000236993.
    KOiK00443.
    OMAiCPPSPEI.

    Family and domain databases

    Gene3Di3.40.50.700. 1 hit.
    InterProiIPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR017681. Coenz_F420_hydrogenase_gsu.
    IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
    [Graphical view]
    PfamiPF13237. Fer4_10. 1 hit.
    PF01058. Oxidored_q6. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03294. FrhG. 1 hit.
    PROSITEiPS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D9PYF7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLIARIKRF LGLEAEAKRE EPEKEKSEPV GASKEEVEKV AEENAKPRIG    50
    YIHLSGCTGD AMSLTENYDI LAELLTNMVD IVYGQTLVDL WEMPEMDLAL 100
    VEGSVCLQDE HSLHELKELR EKAKLVCAFG SCAATGCFTR YSRGGQQAQP 150
    SHESFVPIAD LIDVDLALPG CPPSPEIIAK TVVALLNNDM DYLQPMLDLA 200
    GYTEACGCDL QTKVVNQGLC IGCGTCAMAC QTRALDMTNG RPELNSDRCI 250
    KCGICYVQCP RSWWPEEQIK KELGL 275
    Length:275
    Mass (Da):30,238
    Last modified:October 5, 2010 - v1
    Checksum:i858E41DFB402030A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001710 Genomic DNA. Translation: ADL59255.1.
    RefSeqiYP_003850568.1. NC_014408.1.

    Genome annotation databases

    EnsemblBacteriaiADL59255; ADL59255; MTBMA_c16840.
    GeneIDi9705395.
    KEGGimmg:MTBMA_c16840.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001710 Genomic DNA. Translation: ADL59255.1 .
    RefSeqi YP_003850568.1. NC_014408.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3ZFS electron microscopy 4.00 B 1-275 [» ]
    4CI0 electron microscopy 3.36 B 1-275 [» ]
    4OMF X-ray 1.71 G 1-275 [» ]
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ADL59255 ; ADL59255 ; MTBMA_c16840 .
    GeneIDi 9705395.
    KEGGi mmg:MTBMA_c16840.

    Phylogenomic databases

    HOGENOMi HOG000236993.
    KOi K00443.
    OMAi CPPSPEI.

    Enzyme and pathway databases

    BioCyci MMAR79929:GH5J-1690-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.700. 1 hit.
    InterProi IPR017896. 4Fe4S_Fe-S-bd.
    IPR017900. 4Fe4S_Fe_S_CS.
    IPR017681. Coenz_F420_hydrogenase_gsu.
    IPR006137. NADH_UbQ_OxRdtase-like_20kDa.
    [Graphical view ]
    Pfami PF13237. Fer4_10. 1 hit.
    PF01058. Oxidored_q6. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03294. FrhG. 1 hit.
    PROSITEi PS00198. 4FE4S_FER_1. 1 hit.
    PS51379. 4FE4S_FER_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Methanothermobacter marburgensis."
      Kaster A., Seedorf H., Goenrich M., Wiezer A., Liesegang H., Thauer R., Gottschalk G.
      Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Marburg.
    2. "Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
      Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
      J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / MarburgImported.
    3. "De novo modeling of the F420-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy."
      Mills D.J., Vitt S., Strauss M., Shima S., Vonck J.
      Elife 2:e00218-e00218(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY ELECTRON MICROSCOPY (4.00 ANGSTROMS) IN COMPLEX WITH IRON-SULFUR(4FE-4S).
    4. "Atomic model of the F420-reducing [NiFe] hydrogenase by electron cryo-microscopy using a direct electron detector."
      Allegretti M., Mills D.J., McMullan G., Kuhlbrandt W., Vonck J.
      Elife 3:e01963-e01963(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY ELECTRON MICROSCOPY (3.36 ANGSTROMS) IN COMPLEX WITH IRON-SULFUR(4FE-4S).

    Entry informationi

    Entry nameiD9PYF7_METTM
    AccessioniPrimary (citable) accession number: D9PYF7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteomeImported

    External Data

    Dasty 3