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D9PYF6

- D9PYF6_METTM

UniProt

D9PYF6 - D9PYF6_METTM

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Protein
Submitted name:

F420-reducing hydrogenase, subunit beta

Gene

frhB

Organism
Methanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei48 – 481FAD; via amide nitrogenImported
Metal bindingi103 – 1031Iron-sulfur(4Fe-4S) 1Imported
Metal bindingi103 – 1031Iron-sulfur(4Fe-4S) 2Imported
Metal bindingi104 – 1041Iron-sulfur(4Fe-4S) 1Imported
Metal bindingi104 – 1041Iron-sulfur(4Fe-4S) 2Imported
Metal bindingi134 – 1341Iron-sulfur(4Fe-4S) 1Imported
Metal bindingi134 – 1341Iron-sulfur(4Fe-4S) 2Imported
Metal bindingi192 – 1921Iron-sulfur(4Fe-4S) 1Imported
Metal bindingi195 – 1951Iron-sulfur(4Fe-4S) 1Imported
Binding sitei198 – 1981FADImported

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi24 – 307FADImported
Nucleotide bindingi73 – 775FADImported
Nucleotide bindingi133 – 1353FADImported
Nucleotide bindingi207 – 2104FADImported

GO - Molecular functioni

  1. coenzyme F420 hydrogenase activity Source: UniProtKB-EC
  2. flavin adenine dinucleotide binding Source: InterPro
  3. iron-sulfur cluster binding Source: InterPro
  4. nickel cation binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseImported

Keywords - Ligandi

FADImported, Flavoprotein, Metal-bindingImported, Nucleotide-bindingImported

Enzyme and pathway databases

BioCyciMMAR79929:GH5J-1689-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
F420-reducing hydrogenase, subunit betaImported (EC:1.12.98.1Imported)
Gene namesi
Name:frhBImported
Ordered Locus Names:MTBMA_c16830Imported
OrganismiMethanothermobacter marburgensis (strain DSM 2133 / 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)Imported
Taxonomic identifieri79929 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
ProteomesiUP000000345: Chromosome

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3ZFSelectron microscopy4.00C1-281[»]
4CI0electron microscopy3.36C1-281[»]
4OMFX-ray1.71B1-281[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000223731.
KOiK00441.
OMAiMENFPYN.

Family and domain databases

InterProiIPR007516. Co_F420_Hydgase/DH_bsu_N.
IPR017679. Coenz_F420_hydrogenase_bsu.
IPR007525. FrhB_FdhB_C.
[Graphical view]
PfamiPF04432. FrhB_FdhB_C. 1 hit.
PF04422. FrhB_FdhB_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03289. frhB. 1 hit.

Sequencei

Sequence statusi: Complete.

D9PYF6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLGTYKEIV SARSTDREIQ KLAQDGGIVT GLLAYALDEG IIEGAVVAGP
60 70 80 90 100
GEEFWKPQPM VAMSSDELKA AAGTKYTFSP NVMMLKKAVR QYGIEKLGTV
110 120 130 140 150
AIPCQTMGIR KMQTYPFGVR FLADKIKLLV GIYCMENFPY TSLQTFICEK
160 170 180 190 200
LGVSMELVEK MDIGKGKFWV YTQDDVLTLP LKETHGYEQA GCKICKDYVA
210 220 230 240 250
ELADVSTGSV GSPDGWSTVI TRTDAGDSIF KQAVEAGLFE TKPIEEVKPG
260 270 280
LGLLEKLAAQ KKEKAEKNIA ARKEMGLPTP F
Length:281
Mass (Da):30,744
Last modified:October 5, 2010 - v1
Checksum:i1E981B4ADF3B1A16
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001710 Genomic DNA. Translation: ADL59254.1.
RefSeqiYP_003850567.1. NC_014408.1.

Genome annotation databases

EnsemblBacteriaiADL59254; ADL59254; MTBMA_c16830.
GeneIDi9705394.
KEGGimmg:MTBMA_c16830.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001710 Genomic DNA. Translation: ADL59254.1 .
RefSeqi YP_003850567.1. NC_014408.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3ZFS electron microscopy 4.00 C 1-281 [» ]
4CI0 electron microscopy 3.36 C 1-281 [» ]
4OMF X-ray 1.71 B 1-281 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ADL59254 ; ADL59254 ; MTBMA_c16830 .
GeneIDi 9705394.
KEGGi mmg:MTBMA_c16830.

Phylogenomic databases

HOGENOMi HOG000223731.
KOi K00441.
OMAi MENFPYN.

Enzyme and pathway databases

BioCyci MMAR79929:GH5J-1689-MONOMER.

Family and domain databases

InterProi IPR007516. Co_F420_Hydgase/DH_bsu_N.
IPR017679. Coenz_F420_hydrogenase_bsu.
IPR007525. FrhB_FdhB_C.
[Graphical view ]
Pfami PF04432. FrhB_FdhB_C. 1 hit.
PF04422. FrhB_FdhB_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03289. frhB. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of Methanothermobacter marburgensis."
    Kaster A., Seedorf H., Goenrich M., Wiezer A., Liesegang H., Thauer R., Gottschalk G.
    Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Marburg.
  2. "Complete genome sequence of Methanothermobacter marburgensis, a methanoarchaeon model organism."
    Liesegang H., Kaster A.K., Wiezer A., Goenrich M., Wollherr A., Seedorf H., Gottschalk G., Thauer R.K.
    J. Bacteriol. 192:5850-5851(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 2133 / 14651 / NBRC 100331 / OCM 82 / MarburgImported.
  3. "De novo modeling of the F420-reducing [NiFe]-hydrogenase from a methanogenic archaeon by cryo-electron microscopy."
    Mills D.J., Vitt S., Strauss M., Shima S., Vonck J.
    Elife 2:e00218-e00218(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (4.00 ANGSTROMS) IN COMPLEX WITH FAD AND IRON-SULFUR(4FE-4S).
  4. "Atomic model of the F420-reducing [NiFe] hydrogenase by electron cryo-microscopy using a direct electron detector."
    Allegretti M., Mills D.J., McMullan G., Kuhlbrandt W., Vonck J.
    Elife 3:e01963-e01963(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (3.36 ANGSTROMS) IN COMPLEX WITH FAD AND IRON-SULFUR(4FE-4S).

Entry informationi

Entry nameiD9PYF6_METTM
AccessioniPrimary (citable) accession number: D9PYF6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 26, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteomeImported

External Data

Dasty 3