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Protein

Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)

Gene

uppS

Organism
Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Catalytic activityi

Geranylgeranyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + tritrans,heptacis-undecaprenyl diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei33UniRule annotation1
Metal bindingi33MagnesiumUniRule annotation1
Binding sitei51SubstrateUniRule annotation1
Active sitei82Proton acceptorUniRule annotation1
Binding sitei83SubstrateUniRule annotation1
Binding sitei85SubstrateUniRule annotation1
Binding sitei204SubstrateUniRule annotation1
Metal bindingi223MagnesiumUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseUniRule annotationImported
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Enzyme and pathway databases

BioCyciMMAR79929:G1GML-677-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Tritrans,polycis-undecaprenyl-diphosphate synthase (geranylgeranyl-diphosphate specific)UniRule annotation (EC:2.5.1.89UniRule annotation)
Alternative name(s):
Undecaprenyl diphosphate synthaseUniRule annotation
Short name:
UDSUniRule annotation
Undecaprenyl pyrophosphate synthaseUniRule annotation
Short name:
UPP synthaseUniRule annotation
Gene namesi
Name:uppSUniRule annotationImported
Ordered Locus Names:MTBMA_c06810Imported
OrganismiMethanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum)Imported
Taxonomic identifieri79929 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanobacteriaMethanobacterialesMethanobacteriaceaeMethanothermobacter
Proteomesi
  • UP000000345 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi79929.MTBMA_c06810

Structurei

3D structure databases

ProteinModelPortaliD9PVM8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 37Substrate bindingUniRule annotation4
Regioni79 – 81Substrate bindingUniRule annotation3
Regioni210 – 212Substrate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01532 Archaea
COG0020 LUCA
HOGENOMiHOG000006056
KOiK15888
OMAiFDRRDLW
OrthoDBiPOG093Z09YM

Family and domain databases

CDDicd00475 Cis_IPPS, 1 hit
Gene3Di3.40.1180.10, 1 hit
HAMAPiMF_01139 ISPT, 1 hit
InterProiView protein in InterPro
IPR001441 UPP_synth-like
IPR018520 UPP_synth-like_CS
IPR036424 UPP_synth-like_sf
PANTHERiPTHR10291 PTHR10291, 1 hit
PfamiView protein in Pfam
PF01255 Prenyltransf, 1 hit
SUPFAMiSSF64005 SSF64005, 1 hit
TIGRFAMsiTIGR00055 uppS, 1 hit
PROSITEiView protein in PROSITE
PS01066 UPP_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

D9PVM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPLKPLYKL YEWYISRNLK RERMPRHVAI IMDGNRRYSR LQGSVDPIEG
60 70 80 90 100
HKKGIETLEK VLDWCVDLGI EIITAYAFST ENFKRPENEV KGLMKLFKEN
110 120 130 140 150
FEAIASNKKI HKNRVKVKAV GKLELLPEDV RKAIEVAERS TEGYSDRLVN
160 170 180 190 200
IAIGYDGRQE ILDAARKIAE DVRAGRIDPE DIDEDMINRN LYTAGLEDPH
210 220 230 240 250
LIIRTSGEER LSGFLLWQSS YSELYFCDSL WPELRKVDFL RAIRSYQQRE

RRFGT
Length:255
Mass (Da):29,770
Last modified:October 5, 2010 - v1
Checksum:i02FB93287B359E93
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001710 Genomic DNA Translation: ADL58276.1
RefSeqiWP_013295500.1, NC_014408.1

Genome annotation databases

EnsemblBacteriaiADL58276; ADL58276; MTBMA_c06810
GeneIDi9704389
KEGGimmg:MTBMA_c06810
PATRICifig|79929.8.peg.666

Similar proteinsi

Entry informationi

Entry nameiD9PVM8_METTM
AccessioniPrimary (citable) accession number: D9PVM8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: February 28, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

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