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D9N168 (D9N168_GEOSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA polymerase RuleBase RU004460

EC=2.7.7.7 RuleBase RU004460
Gene names
Name:DPO1 PDB 3HT3
OrganismGeobacillus stearothermophilus (Bacillus stearothermophilus) PDB 3HT3
Taxonomic identifier1422 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Protein attributes

Sequence length579 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). RuleBase RU004460

Sequence similarities

Belongs to the DNA polymerase type-A family.

Sequences

Sequence LengthMass (Da)Tools
D9N168 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: CDEDB059CBA01889

FASTA57965,967
        10         20         30         40         50         60 
KMAFTLADRV TEEMLADKAA LVVEVVEENY HDAPIVGIAV VNEHGRFFLR PETALADPQF 

        70         80         90        100        110        120 
VAWLGDETKK KSMFDSKRAA VALKWKGIEL CGVSFDLLLA AYLLDPAQGV DDVAAAAKMK 

       130        140        150        160        170        180 
QYEAVRPDEA VYGKGAKRAV PDEPVLAEHL VRKAAAIWEL ERPFLDELRR NEQDRLLVEL 

       190        200        210        220        230        240 
EQPLSSILAE MEFAGVKVDT KRLEQMGKEL AEQLGTVEQR IYELAGQEFN INSPKQLGVI 

       250        260        270        280        290        300 
LFEKLQLPVL KKTKTGYSTS ADVLEKLAPY HEIVENILHY RQLGKLQSTY IEGLLKVVRP 

       310        320        330        340        350        360 
ATKKVHTIFN QALTQTGRLS STEPNLQNIP IRLEEGRKIR QAFVPSESDW LIFAADYSQI 

       370        380        390        400        410        420 
ELRVLAHIAE DDNLMEAFRR DLDIHTKTAM DIFQVSEDEV TPNMRRQAKA VNFGIPYGIS 

       430        440        450        460        470        480 
DYGLAQNLNI SRKEAAEFIE RYFESFPGVK RYMENIVQEA KQKGYVTTLL HRRRYLPDIT 

       490        500        510        520        530        540 
SRNFNVRSFA ERMAMNTPIQ GSAADIIKKA MIDLNARLKE ERLQAHLLLQ VHDELILEAP 

       550        560        570 
KEEMERLCRL VPEVMEQAVT LRVPLKVDYH YGSTWYDAK 

« Hide

References

[1]"The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism."
Wu E.Y., Beese L.S.
J. Biol. Chem. 286:19758-19767(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).

Cross-references

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3HT3X-ray1.70A/D1-579[»]
ProteinModelPortalD9N168.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D3.30.420.10. 1 hit.
InterProIPR002562. 3'-5'_exonuclease_dom.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamPF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSPR00868. DNAPOLI.
SMARTSM00474. 35EXOc. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMSSF53098. SSF53098. 1 hit.
TIGRFAMsTIGR00593. pola. 1 hit.
PROSITEPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceD9N168.

Entry information

Entry nameD9N168_GEOSE
AccessionPrimary (citable) accession number: D9N168
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)