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D9N168

- D9N168_GEOSE

UniProt

D9N168 - D9N168_GEOSE

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Protein

DNA polymerase

Gene
DPO1
Organism
Geobacillus stearothermophilus (Bacillus stearothermophilus)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).UniRule annotation

GO - Molecular functioni

  1. 3'-5' exonuclease activity Source: InterPro
  2. DNA binding Source: UniProtKB-KW
  3. DNA-directed DNA polymerase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

NucleotidyltransferaseUniRule annotation, Transferase

Keywords - Biological processi

DNA replicationUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymeraseUniRule annotation (EC:2.7.7.7UniRule annotation)
Gene namesi
Name:DPO1Imported
OrganismiGeobacillus stearothermophilus (Bacillus stearothermophilus)Imported
Taxonomic identifieri1422 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeGeobacillus

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3HT3X-ray1.70A/D1-579[»]
ProteinModelPortaliD9N168.

Miscellaneous databases

EvolutionaryTraceiD9N168.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR002562. 3'-5'_exonuclease_dom.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF00476. DNA_pol_A. 1 hit.
[Graphical view]
PRINTSiPR00868. DNAPOLI.
SMARTiSM00474. 35EXOc. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00593. pola. 1 hit.
PROSITEiPS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D9N168-1 [UniParc]FASTAAdd to Basket

« Hide

KMAFTLADRV TEEMLADKAA LVVEVVEENY HDAPIVGIAV VNEHGRFFLR    50
PETALADPQF VAWLGDETKK KSMFDSKRAA VALKWKGIEL CGVSFDLLLA 100
AYLLDPAQGV DDVAAAAKMK QYEAVRPDEA VYGKGAKRAV PDEPVLAEHL 150
VRKAAAIWEL ERPFLDELRR NEQDRLLVEL EQPLSSILAE MEFAGVKVDT 200
KRLEQMGKEL AEQLGTVEQR IYELAGQEFN INSPKQLGVI LFEKLQLPVL 250
KKTKTGYSTS ADVLEKLAPY HEIVENILHY RQLGKLQSTY IEGLLKVVRP 300
ATKKVHTIFN QALTQTGRLS STEPNLQNIP IRLEEGRKIR QAFVPSESDW 350
LIFAADYSQI ELRVLAHIAE DDNLMEAFRR DLDIHTKTAM DIFQVSEDEV 400
TPNMRRQAKA VNFGIPYGIS DYGLAQNLNI SRKEAAEFIE RYFESFPGVK 450
RYMENIVQEA KQKGYVTTLL HRRRYLPDIT SRNFNVRSFA ERMAMNTPIQ 500
GSAADIIKKA MIDLNARLKE ERLQAHLLLQ VHDELILEAP KEEMERLCRL 550
VPEVMEQAVT LRVPLKVDYH YGSTWYDAK 579
Length:579
Mass (Da):65,967
Last modified:October 5, 2010 - v1
Checksum:iCDEDB059CBA01889
GO

Cross-referencesi

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3HT3 X-ray 1.70 A/D 1-579 [» ]
ProteinModelPortali D9N168.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei D9N168.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
InterProi IPR002562. 3'-5'_exonuclease_dom.
IPR019760. DNA-dir_DNA_pol_A_CS.
IPR001098. DNA-dir_DNA_pol_A_palm_dom.
IPR018320. DNA_polymerase_1.
IPR002298. DNA_polymerase_A.
IPR012337. RNaseH-like_dom.
[Graphical view ]
Pfami PF00476. DNA_pol_A. 1 hit.
[Graphical view ]
PRINTSi PR00868. DNAPOLI.
SMARTi SM00474. 35EXOc. 1 hit.
SM00482. POLAc. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
TIGRFAMsi TIGR00593. pola. 1 hit.
PROSITEi PS00447. DNA_POLYMERASE_A. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The structure of a high fidelity DNA polymerase bound to a mismatched nucleotide reveals an "ajar" intermediate conformation in the nucleotide selection mechanism."
    Wu E.Y., Beese L.S.
    J. Biol. Chem. 286:19758-19767(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS).

Entry informationi

Entry nameiD9N168_GEOSE
AccessioniPrimary (citable) accession number: D9N168
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: April 16, 2014
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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