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Protein

WD repeat-containing protein 20 homolog

Gene

wdr-20

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Together with wdr-48, binds to and stimulates the activity of the deubiquitinating enzyme usp-46, leading to deubiquitination and stabilization of the glr-1 glutamate receptor.1 Publication

GO - Biological processi

  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of locomotion involved in locomotory behavior Source: UniProtKB
  • positive regulation of protein deubiquitination Source: UniProtKB
  • positive regulation of protein localization to cell surface Source: UniProtKB

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-CEL-5689880. Ub-specific processing proteases.
SignaLinkiD9N129.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 20 homologBy similarity
Gene namesi
Name:wdr-20Imported
ORF Names:C08B6.7
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiC08B6.7a; CE05244; WBGene00007428; wdr-20.
C08B6.7b; CE45162; WBGene00007428; wdr-20.

Pathology & Biotechi

Disruption phenotypei

25% decrease in glr-1 expression in the ventral nerve cord. Changed locomotion behavior with mutants displaying decreased reversal frequencies consistent with decreased glutamergic signaling.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004300791 – 768WD repeat-containing protein 20 homologAdd BLAST768

Proteomic databases

EPDiD9N129.
PaxDbiD9N129.
PeptideAtlasiD9N129.

Expressioni

Tissue specificityi

Expressed in several neurons in the head and tail.1 Publication

Gene expression databases

BgeeiWBGene00007428.

Interactioni

Subunit structurei

Interacts with usp-46; the interaction increases the catalytic activity of usp-46 in the presence of wdr-48.1 Publication

Protein-protein interaction databases

STRINGi6239.C08B6.7b.1.

Structurei

3D structure databases

ProteinModelPortaliD9N129.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati224 – 264WD 1Sequence analysisAdd BLAST41
Repeati302 – 342WD 2Sequence analysisAdd BLAST41
Repeati345 – 384WD 3Sequence analysisAdd BLAST40
Repeati454 – 497WD 4Sequence analysisAdd BLAST44
Repeati646 – 683WD 5Sequence analysisAdd BLAST38

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2394. Eukaryota.
COG2319. LUCA.
GeneTreeiENSGT00390000007686.
HOGENOMiHOG000007484.
InParanoidiD9N129.
OMAiNVENTCG.
OrthoDBiEOG091G05SY.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR011042. 6-blade_b-propeller_TolB-like.
IPR015943. WD40/YVTN_repeat-like_dom_sf.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
IPR036322. WD40_repeat_dom_sf.
SMARTiView protein in SMART
SM00320. WD40. 5 hits.
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform b1 Publication (identifier: D9N129-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHQHMLGPST SLGGTNNSAL QSSVLSEGVL LSHSQPTREE IKKNFETREG
60 70 80 90 100
VYRSVPSAEF SRPRPLPQYH MPPGIASAAA SQIAAAGSTV RVSFLNGAEK
110 120 130 140 150
SVESPEAVAP TSSTYEHHKN EPNGARIDMV DEAQADKICF NVGKELYVFS
160 170 180 190 200
YRGTQTETDL SRPIDKRVYK GTSPTYHAFN QESAKNGSCQ LLIGFTLGQL
210 220 230 240 250
QIIDPLEKSS SSPFSRLYNE DRYIEKTSVT CIRWLPGDSN IFLASYVSGN
260 270 280 290 300
LYVYDQRISA ASSNNNGSSQ PPPWTIHKEG DKFAIHTWKG KVQRNPVTRW
310 320 330 340 350
QIGEGSIHQF SFSGSDGKMM ATVSHDGFLR IFNYHAQELL AVMKSYFGGL
360 370 380 390 400
LTLSWSPDAK LIATGGEDDL LTVYSVAEKR VVCRGQAHKS WVSQVKFDPY
410 420 430 440 450
LCTTEEDLEN NGIAMTSTFD DVAKDFSIRS GPVPSTSADL NSGVMNATST
460 470 480 490 500
FSRCSLASFN TINGAPAGNS VRYRIGSVGH DTFLCLWDIT EDMLNQGNIR
510 520 530 540 550
RHRNSTIIAP MTTLEVQTNS LVGRLEDLQE VSPGGAGVNA SSDSQSITNN
560 570 580 590 600
HTTPRPEKQK KKKFTKRLGF SKFTSGSSSA TSNPVGGHKI GTLMNGASVN
610 620 630 640 650
SESSKKQNPG LISQISCCNE TRMLGSKFCP GIRDVPMIEP LMCKKVSHDR
660 670 680 690 700
LTVLEFREDC VVTACQEGYI CTWGRPGRYQ PKRDCINSPG TASPESGQKP
710 720 730 740 750
SGSTSAMTSS YGYGSDALNG VPPSRSSSTY SNSEQQLRSP NITSPSYRVS
760
AASTSVYHRP TYAWQNAN
Note: No experimental confirmation available.Curated
Length:768
Mass (Da):83,741
Last modified:October 5, 2010 - v1
Checksum:iD0FF711E8BFE3F2F
GO
Isoform a1 Publication (identifier: D9N129-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     733-751: SEQQLRSPNITSPSYRVSA → T

Note: No experimental confirmation available.Curated
Show »
Length:750
Mass (Da):81,740
Checksum:iAF18BA10A15B1831
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055505733 – 751SEQQL…YRVSA → T in isoform a. 1 PublicationAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z72502 Genomic DNA. Translation: CAA96589.1.
Z72502 Genomic DNA. Translation: CBO21933.1.
RefSeqiNP_001256184.1. NM_001269255.1. [D9N129-1]
NP_001335505.1. NM_001348580.1.
UniGeneiCel.22559.

Genome annotation databases

EnsemblMetazoaiC08B6.7b; C08B6.7b; WBGene00007428. [D9N129-1]
GeneIDi179410.
KEGGicel:CELE_C08B6.7.
UCSCiC08B6.7. c. elegans.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiWDR20_CAEEL
AccessioniPrimary (citable) accession number: D9N129
Secondary accession number(s): Q17818
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 3, 2014
Last sequence update: October 5, 2010
Last modified: November 22, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase