Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Prostaglandin-endoperoxidase synthase 2

Gene

PTGS2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. heme binding Source: Ensembl
  2. lipid binding Source: Ensembl
  3. oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Source: Ensembl
  4. peroxidase activity Source: UniProtKB-KW
  5. prostaglandin-endoperoxide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. bone mineralization Source: Ensembl
  3. brown fat cell differentiation Source: Ensembl
  4. cellular response to ATP Source: Ensembl
  5. cellular response to mechanical stimulus Source: Ensembl
  6. cellular response to UV Source: Ensembl
  7. cyclooxygenase pathway Source: Ensembl
  8. decidualization Source: Ensembl
  9. embryo implantation Source: Ensembl
  10. hair cycle Source: Ensembl
  11. inflammatory response Source: Ensembl
  12. learning Source: Ensembl
  13. maintenance of blood-brain barrier Source: Ensembl
  14. memory Source: Ensembl
  15. negative regulation of calcium ion transport Source: Ensembl
  16. negative regulation of cell cycle Source: Ensembl
  17. negative regulation of cell proliferation Source: Ensembl
  18. negative regulation of smooth muscle contraction Source: Ensembl
  19. negative regulation of synaptic transmission, dopaminergic Source: Ensembl
  20. ovulation Source: Ensembl
  21. positive regulation of apoptotic process Source: Ensembl
  22. positive regulation of brown fat cell differentiation Source: Ensembl
  23. positive regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
  24. positive regulation of fever generation Source: Ensembl
  25. positive regulation of fibroblast growth factor production Source: Ensembl
  26. positive regulation of NF-kappaB import into nucleus Source: Ensembl
  27. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  28. positive regulation of platelet-derived growth factor production Source: Ensembl
  29. positive regulation of smooth muscle cell proliferation Source: Ensembl
  30. positive regulation of smooth muscle contraction Source: Ensembl
  31. positive regulation of synaptic plasticity Source: Ensembl
  32. positive regulation of synaptic transmission, glutamatergic Source: Ensembl
  33. positive regulation of transforming growth factor beta production Source: Ensembl
  34. positive regulation of vasoconstriction Source: Ensembl
  35. positive regulation vascular endothelial growth factor production Source: Ensembl
  36. regulation of blood pressure Source: Ensembl
  37. response to drug Source: Ensembl
  38. response to estradiol Source: Ensembl
  39. response to fatty acid Source: Ensembl
  40. response to fructose Source: Ensembl
  41. response to glucocorticoid Source: Ensembl
  42. response to lipopolysaccharide Source: Ensembl
  43. response to lithium ion Source: Ensembl
  44. response to manganese ion Source: Ensembl
  45. response to tumor necrosis factor Source: Ensembl
  46. response to vitamin D Source: Ensembl
  47. sensory perception of pain Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, PeroxidaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin-endoperoxidase synthase 2Imported (EC:1.14.99.1Imported)
Gene namesi
Name:PTGS2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. neuron projection Source: Ensembl
  4. protein complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD9MWI3.
ExpressionAtlasiD9MWI3. baseline and differential.

Interactioni

Family & Domainsi

Family and domain databases

InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D9MWI3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
RGVCMSVGFD QYKCDCTRTG FYGENCSTPE FLTRIKLFLK PTPNTVHYIL

THF
Length:53
Mass (Da):6,137
Last modified:October 5, 2010 - v1
Checksum:i2F521E820A121F80
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei53 – 531Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM473188 mRNA. Translation: ADJ56342.1.
UniGeneiHs.196384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM473188 mRNA. Translation: ADJ56342.1.
UniGeneiHs.196384.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiD9MWI3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

NextBioi35495912.

Gene expression databases

BgeeiD9MWI3.
ExpressionAtlasiD9MWI3. baseline and differential.

Family and domain databases

InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "COX2 gene expression in peripheral blood leukocytes."
    Esmaeili B., Rafatpanah H., Rezaee A., Layegh P., Esmaeili S., Kalalinia F., Mosafa F., Negari S., Amani J.
    Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiD9MWI3_HUMAN
AccessioniPrimary (citable) accession number: D9MWI3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 26, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.