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D9MWI3

- D9MWI3_HUMAN

UniProt

D9MWI3 - D9MWI3_HUMAN

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Protein
Submitted name:

Prostaglandin-endoperoxidase synthase 2

Gene

PTGS2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. heme binding Source: Ensembl
  2. lipid binding Source: Ensembl
  3. oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Source: Ensembl
  4. peroxidase activity Source: UniProtKB-KW
  5. prostaglandin-endoperoxide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. angiogenesis Source: Ensembl
  2. bone mineralization Source: Ensembl
  3. brown fat cell differentiation Source: Ensembl
  4. cellular response to ATP Source: Ensembl
  5. cellular response to mechanical stimulus Source: Ensembl
  6. cellular response to UV Source: Ensembl
  7. cyclooxygenase pathway Source: Ensembl
  8. decidualization Source: Ensembl
  9. embryo implantation Source: Ensembl
  10. hair cycle Source: Ensembl
  11. inflammatory response Source: Ensembl
  12. learning Source: Ensembl
  13. maintenance of blood-brain barrier Source: Ensembl
  14. memory Source: Ensembl
  15. negative regulation of calcium ion transport Source: Ensembl
  16. negative regulation of cell cycle Source: Ensembl
  17. negative regulation of cell proliferation Source: Ensembl
  18. negative regulation of smooth muscle contraction Source: Ensembl
  19. negative regulation of synaptic transmission, dopaminergic Source: Ensembl
  20. ovulation Source: Ensembl
  21. positive regulation of apoptotic process Source: Ensembl
  22. positive regulation of brown fat cell differentiation Source: Ensembl
  23. positive regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
  24. positive regulation of fever generation Source: Ensembl
  25. positive regulation of fibroblast growth factor production Source: Ensembl
  26. positive regulation of NF-kappaB import into nucleus Source: Ensembl
  27. positive regulation of nitric oxide biosynthetic process Source: Ensembl
  28. positive regulation of platelet-derived growth factor production Source: Ensembl
  29. positive regulation of smooth muscle cell proliferation Source: Ensembl
  30. positive regulation of smooth muscle contraction Source: Ensembl
  31. positive regulation of synaptic plasticity Source: Ensembl
  32. positive regulation of synaptic transmission, glutamatergic Source: Ensembl
  33. positive regulation of transforming growth factor beta production Source: Ensembl
  34. positive regulation of vasoconstriction Source: Ensembl
  35. positive regulation vascular endothelial growth factor production Source: Ensembl
  36. regulation of blood pressure Source: Ensembl
  37. response to drug Source: Ensembl
  38. response to estradiol Source: Ensembl
  39. response to fatty acid Source: Ensembl
  40. response to fructose Source: Ensembl
  41. response to glucocorticoid Source: Ensembl
  42. response to lipopolysaccharide Source: Ensembl
  43. response to lithium ion Source: Ensembl
  44. response to manganese ion Source: Ensembl
  45. response to tumor necrosis factor Source: Ensembl
  46. response to vitamin D Source: Ensembl
  47. sensory perception of pain Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, PeroxidaseImported

Names & Taxonomyi

Protein namesi
Submitted name:
Prostaglandin-endoperoxidase synthase 2Imported (EC:1.14.99.1Imported)
Gene namesi
Name:PTGS2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. caveola Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. neuron projection Source: Ensembl
  4. protein complex Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiD9MWI3.
ExpressionAtlasiD9MWI3. baseline and differential.

Interactioni

Family & Domainsi

Family and domain databases

InterProiIPR029576. COX-2.
IPR000742. EG-like_dom.
[Graphical view]
PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
PROSITEiPS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

D9MWI3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
RGVCMSVGFD QYKCDCTRTG FYGENCSTPE FLTRIKLFLK PTPNTVHYIL

THF
Length:53
Mass (Da):6,137
Last modified:October 5, 2010 - v1
Checksum:i2F521E820A121F80
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei53 – 531Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM473188 mRNA. Translation: ADJ56342.1.
UniGeneiHs.196384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
HM473188 mRNA. Translation: ADJ56342.1 .
UniGenei Hs.196384.

3D structure databases

ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi D9MWI3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

NextBioi 35495912.

Gene expression databases

Bgeei D9MWI3.
ExpressionAtlasi D9MWI3. baseline and differential.

Family and domain databases

InterProi IPR029576. COX-2.
IPR000742. EG-like_dom.
[Graphical view ]
PANTHERi PTHR11903:SF8. PTHR11903:SF8. 1 hit.
PROSITEi PS50026. EGF_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "COX2 gene expression in peripheral blood leukocytes."
    Esmaeili B., Rafatpanah H., Rezaee A., Layegh P., Esmaeili S., Kalalinia F., Mosafa F., Negari S., Amani J.
    Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiD9MWI3_HUMAN
AccessioniPrimary (citable) accession number: D9MWI3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 26, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.