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D9MWI3

- D9MWI3_HUMAN

UniProt

D9MWI3 - D9MWI3_HUMAN

Protein
Submitted name:

Prostaglandin-endoperoxidase synthase 2

Gene

PTGS2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    GO - Molecular functioni

    1. heme binding Source: Ensembl
    2. lipid binding Source: Ensembl
    3. oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen Source: Ensembl
    4. peroxidase activity Source: UniProtKB-KW
    5. prostaglandin-endoperoxide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. anagen Source: Ensembl
    2. angiogenesis Source: Ensembl
    3. bone mineralization Source: Ensembl
    4. brown fat cell differentiation Source: Ensembl
    5. cellular response to ATP Source: Ensembl
    6. cellular response to mechanical stimulus Source: Ensembl
    7. cellular response to UV Source: Ensembl
    8. cyclooxygenase pathway Source: Ensembl
    9. decidualization Source: Ensembl
    10. embryo implantation Source: Ensembl
    11. inflammatory response Source: Ensembl
    12. learning Source: Ensembl
    13. maintenance of blood-brain barrier Source: Ensembl
    14. memory Source: Ensembl
    15. negative regulation of calcium ion transport Source: Ensembl
    16. negative regulation of cell cycle Source: Ensembl
    17. negative regulation of cell proliferation Source: Ensembl
    18. negative regulation of smooth muscle contraction Source: Ensembl
    19. negative regulation of synaptic transmission, dopaminergic Source: Ensembl
    20. ovulation Source: Ensembl
    21. positive regulation of apoptotic process Source: Ensembl
    22. positive regulation of brown fat cell differentiation Source: Ensembl
    23. positive regulation of cell migration involved in sprouting angiogenesis Source: Ensembl
    24. positive regulation of fever generation Source: Ensembl
    25. positive regulation of fibroblast growth factor production Source: Ensembl
    26. positive regulation of NF-kappaB import into nucleus Source: Ensembl
    27. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    28. positive regulation of platelet-derived growth factor production Source: Ensembl
    29. positive regulation of smooth muscle cell proliferation Source: Ensembl
    30. positive regulation of smooth muscle contraction Source: Ensembl
    31. positive regulation of synaptic plasticity Source: Ensembl
    32. positive regulation of synaptic transmission, glutamatergic Source: Ensembl
    33. positive regulation of transforming growth factor beta production Source: Ensembl
    34. positive regulation of vasoconstriction Source: Ensembl
    35. positive regulation vascular endothelial growth factor production Source: Ensembl
    36. regulation of blood pressure Source: Ensembl
    37. response to drug Source: Ensembl
    38. response to estradiol Source: Ensembl
    39. response to fatty acid Source: Ensembl
    40. response to fructose Source: Ensembl
    41. response to glucocorticoid Source: Ensembl
    42. response to lipopolysaccharide Source: Ensembl
    43. response to lithium ion Source: Ensembl
    44. response to manganese ion Source: Ensembl
    45. response to tumor necrosis factor Source: Ensembl
    46. response to vitamin D Source: Ensembl
    47. sensory perception of pain Source: Ensembl

    Keywords - Molecular functioni

    Oxidoreductase, PeroxidaseImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Prostaglandin-endoperoxidase synthase 2Imported (EC:1.14.99.1Imported)
    Gene namesi
    Name:PTGS2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. neuron projection Source: Ensembl
    3. protein complex Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiD9MWI3.
    BgeeiD9MWI3.

    Interactioni

    Family & Domainsi

    Family and domain databases

    InterProiIPR029576. COX-2.
    IPR000742. EG-like_dom.
    [Graphical view]
    PANTHERiPTHR11903:SF8. PTHR11903:SF8. 1 hit.
    PROSITEiPS50026. EGF_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    D9MWI3-1 [UniParc]FASTAAdd to Basket

    « Hide

    RGVCMSVGFD QYKCDCTRTG FYGENCSTPE FLTRIKLFLK PTPNTVHYIL   50
    THF 53
    Length:53
    Mass (Da):6,137
    Last modified:October 5, 2010 - v1
    Checksum:i2F521E820A121F80
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei53 – 531Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM473188 mRNA. Translation: ADJ56342.1.
    UniGeneiHs.196384.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    HM473188 mRNA. Translation: ADJ56342.1 .
    UniGenei Hs.196384.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi D9MWI3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    NextBioi 35495912.

    Gene expression databases

    ArrayExpressi D9MWI3.
    Bgeei D9MWI3.

    Family and domain databases

    InterProi IPR029576. COX-2.
    IPR000742. EG-like_dom.
    [Graphical view ]
    PANTHERi PTHR11903:SF8. PTHR11903:SF8. 1 hit.
    PROSITEi PS50026. EGF_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "COX2 gene expression in peripheral blood leukocytes."
      Esmaeili B., Rafatpanah H., Rezaee A., Layegh P., Esmaeili S., Kalalinia F., Mosafa F., Negari S., Amani J.
      Submitted (JUN-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiD9MWI3_HUMAN
    AccessioniPrimary (citable) accession number: D9MWI3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 20 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.