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Protein

Hydroxymethylglutaryl-CoA synthase

Gene

VOLCADRAFT_59473

Organism
Volvox carteri f. nagariensis
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.UniRule annotation

Catalytic activityi

Acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA.UniRule annotation

Pathwayi: (R)-mevalonate biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes (R)-mevalonate from acetyl-CoA.UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Hydroxymethylglutaryl-CoA synthase (VOLCADRAFT_59473)
  3. no protein annotated in this organism
This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotation
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesisUniRule annotation, Sterol metabolism

Enzyme and pathway databases

UniPathwayiUPA00058; UER00102.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxymethylglutaryl-CoA synthaseUniRule annotation (EC:2.3.3.10UniRule annotation)
Short name:
HMG-CoA synthaseUniRule annotation
Alternative name(s):
3-hydroxy-3-methylglutaryl coenzyme A synthaseUniRule annotation
Gene namesi
ORF Names:VOLCADRAFT_59473Imported
OrganismiVolvox carteri f. nagariensisImported
Taxonomic identifieri3068 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesVolvocaceaeVolvox
Proteomesi
  • UP000001058 Componenti: Unassembled WGS sequence

Structurei

3D structure databases

ProteinModelPortaliD8TSV1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 187HMG_CoA_synt_NInterPro annotationAdd BLAST176
Domaini189 – 454HMG_CoA_synt_CInterPro annotationAdd BLAST266

Sequence similaritiesi

Belongs to the HMG-CoA synthase family.UniRule annotation

Phylogenomic databases

InParanoidiD8TSV1.
KOiK01641.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiView protein in InterPro
IPR013746. HMG_CoA_synt_C_dom.
IPR013528. HMG_CoA_synth_N.
IPR010122. HMG_CoA_synthase_euk.
IPR016039. Thiolase-like.
PfamiView protein in Pfam
PF08540. HMG_CoA_synt_C. 1 hit.
PF01154. HMG_CoA_synt_N. 1 hit.
SUPFAMiSSF53901. SSF53901. 3 hits.
TIGRFAMsiTIGR01833. HMG-CoA-S_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

D8TSV1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATYRHGKDR PRPDSVGVLA LEVYFPTQHV LMSDMELADG CPGKYTRGLE
60 70 80 90 100
QEAMSFCSDR EDVVSMALTV AKSLMDKYRV RPAEVGHLQV ATESAVDRSK
110 120 130 140 150
SIKSHLMTLW RRAVGGGPPA EGVDCVHACY GGTAALLAAV DWVESRRWDG
160 170 180 190 200
RLALVVAADV ALYAPGTPAR PTGGCGAAAI LVGPDAPLVL DPLWYGSHAE
210 220 230 240 250
HSWDFYKPLG TLPYPAVDGP RTLVQYLRAM GMCGMRLLDR VQRAGELAPE
260 270 280 290 300
EGVHHFVAHA PFSKLARKGL ARLALMDAIC RAAAGLSSYE SYATWRLEDK
310 320 330 340 350
ELEAQLVAGT TLEWREKAED GSWLQKQVGN SYTASVWQGL ASLVWRQGAQ
360 370 380 390 400
LAGRRLLLFS FGSGTIASLF SLVCGPSDPR FTLESIQGVL DLGERLRARV
410 420 430 440 450
RRPLEVFDAV SAQVVASYAC PVPYEPRGDV ADVAAGSYYL LRVDEHSRRW

YGRKV
Length:455
Mass (Da):49,694
Last modified:October 5, 2010 - v1
Checksum:i0ED94CCB1853DFA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL378335 Genomic DNA. Translation: EFJ49546.1.
RefSeqiXP_002949527.1. XM_002949481.1.

Genome annotation databases

GeneIDi9618698.
KEGGivcn:VOLCADRAFT_59473.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiD8TSV1_VOLCA
AccessioniPrimary (citable) accession number: D8TSV1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: July 5, 2017
This is version 25 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported