ID   D8S9D0_SELML            Unreviewed;       820 AA.
AC   D8S9D0;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   RecName: Full=[Histone H3]-lysine(27) N-trimethyltransferase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=SELMODRAFT_111860 {ECO:0000313|EMBL:EFJ18941.1};
OS   Selaginella moellendorffii (Spikemoss).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Lycopodiopsida; Selaginellales; Selaginellaceae; Selaginella.
OX   NCBI_TaxID=88036 {ECO:0000313|Proteomes:UP000001514};
RN   [1] {ECO:0000313|EMBL:EFJ18941.1, ECO:0000313|Proteomes:UP000001514}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21551031; DOI=10.1126/science.1203810;
RA   Banks J.A., Nishiyama T., Hasebe M., Bowman J.L., Gribskov M.,
RA   dePamphilis C., Albert V.A., Aono N., Aoyama T., Ambrose B.A., Ashton N.W.,
RA   Axtell M.J., Barker E., Barker M.S., Bennetzen J.L., Bonawitz N.D.,
RA   Chapple C., Cheng C., Correa L.G., Dacre M., DeBarry J., Dreyer I.,
RA   Elias M., Engstrom E.M., Estelle M., Feng L., Finet C., Floyd S.K.,
RA   Frommer W.B., Fujita T., Gramzow L., Gutensohn M., Harholt J., Hattori M.,
RA   Heyl A., Hirai T., Hiwatashi Y., Ishikawa M., Iwata M., Karol K.G.,
RA   Koehler B., Kolukisaoglu U., Kubo M., Kurata T., Lalonde S., Li K., Li Y.,
RA   Litt A., Lyons E., Manning G., Maruyama T., Michael T.P., Mikami K.,
RA   Miyazaki S., Morinaga S., Murata T., Mueller-Roeber B., Nelson D.R.,
RA   Obara M., Oguri Y., Olmstead R.G., Onodera N., Petersen B.L., Pils B.,
RA   Prigge M., Rensing S.A., Riano-Pachon D.M., Roberts A.W., Sato Y.,
RA   Scheller H.V., Schulz B., Schulz C., Shakirov E.V., Shibagaki N.,
RA   Shinohara N., Shippen D.E., Soerensen I., Sotooka R., Sugimoto N.,
RA   Sugita M., Sumikawa N., Tanurdzic M., Theissen G., Ulvskov P., Wakazuki S.,
RA   Weng J.K., Willats W.W., Wipf D., Wolf P.G., Yang L., Zimmer A.D., Zhu Q.,
RA   Mitros T., Hellsten U., Loque D., Otillar R., Salamov A., Schmutz J.,
RA   Shapiro H., Lindquist E., Lucas S., Rokhsar D., Grigoriev I.V.;
RT   "The Selaginella genome identifies genetic changes associated with the
RT   evolution of vascular plants.";
RL   Science 332:960-963(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+)
CC         + N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-
CC         homocysteine; Xref=Rhea:RHEA:60292, Rhea:RHEA-COMP:15535, Rhea:RHEA-
CC         COMP:15548, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.356;
CC         Evidence={ECO:0000256|ARBA:ARBA00000090};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GL377608; EFJ18941.1; -; Genomic_DNA.
DR   RefSeq; XP_002980071.1; XM_002980025.1.
DR   AlphaFoldDB; D8S9D0; -.
DR   STRING; 88036.D8S9D0; -.
DR   EnsemblPlants; EFJ18941; EFJ18941; SELMODRAFT_111860.
DR   Gramene; EFJ18941; EFJ18941; SELMODRAFT_111860.
DR   KEGG; smo:SELMODRAFT_111860; -.
DR   eggNOG; KOG1079; Eukaryota.
DR   HOGENOM; CLU_011060_0_0_1; -.
DR   InParanoid; D8S9D0; -.
DR   Proteomes; UP000001514; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0031519; C:PcG protein complex; IEA:InterPro.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0046976; F:histone H3K27 methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0140951; F:histone H3K27 trimethyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0031507; P:heterochromatin formation; IBA:GO_Central.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd10519; SET_EZH; 1.
DR   Gene3D; 2.170.270.10; SET domain; 1.
DR   InterPro; IPR026489; CXC_dom.
DR   InterPro; IPR045318; EZH1/2-like.
DR   InterPro; IPR025778; Hist-Lys_N-MeTrfase_plant.
DR   InterPro; IPR041355; Pre-SET_CXC.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR033467; Tesmin/TSO1-like_CXC.
DR   PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR   PANTHER; PTHR45747:SF4; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR   Pfam; PF18264; preSET_CXC; 1.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM01114; CXC; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SET domain; 1.
DR   PROSITE; PS51633; CXC; 1.
DR   PROSITE; PS51576; SAM_MT43_EZ; 1.
DR   PROSITE; PS50280; SET; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001514};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          559..657
FT                   /note="CXC"
FT                   /evidence="ECO:0000259|PROSITE:PS51633"
FT   DOMAIN          672..787
FT                   /note="SET"
FT                   /evidence="ECO:0000259|PROSITE:PS50280"
FT   REGION          365..401
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          794..820
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        365..387
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        794..808
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   820 AA;  91908 MW;  E4BA710E2EF3518F CRC64;
     MAALSATFTR LKKQVAFERQ AYVKARMDAN SERLQGFCTH LLALSSSRAV NNRNHADNDM
     LNTRIQKALN KLGTDPAAAD QQCGSQDDSS APILFNNSGG KSIVKPVRLQ TVQKTPPYTT
     WIFLDRNQRM AEDQSVVGRR RIYYDSAENE ALICSDSEEE QVEEEEEKRD FSKGDDFLIR
     ATVQEHGSSK MVFKALADCL DAKPSEIEAR YEILAKDGDK LKSEEKHDLL SAMDSFDNLF
     CRRCLVFDCR LHGCSQPVII PFDKQTPLNK TGELPSVPCG PCCFHLPRLS SHHDATSSGV
     ESKPVPVEST APAIEKSWQV PDSKDKGVAT EPVAKTVDKP PEAPKKSFKD KSVTALRRLL
     LKRKATRHTD DDTNEARKKH HVEGSHAEVG DGSGNATRGE NTGASMYLKK LVSKKLYAQR
     KWKGSQITTV KRPPPVIKES EDVMQSISKN LTLYDSNWNT LEKDLYETGL QIFGRDSCLI
     SRNLLRGMKS CAEVGEFMQL EAAVNWKLNE ETKLQQDGNT VIEDATIDRS RSRLYNGRRR
     GRVRRLKYTW KSVGYPAIRK RLVDGKDGCR QYTPCSCSES CGKQCSCHRN GTCCEKYCGC
     SKNCKNRFRG CHCAKSQCSS RQCPCFAAGR ECDPDVCRNC WIGCGDGSQG GPPARGDSYE
     CRNMKLLLKQ QQRVLLGRSD VAGWGAFLKT PVNKHDYLGE YTGELISHRE ADKRGKIYDR
     ENSSFLFNLN DQYVLDACRK GDKLKFANHS PNPNCYAKVI MVAGDHRVGI FAKERISAGE
     ELFYDYRYEA DRAPPWARKP EDGQKNDEAA SGSGRAQKTA
//