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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

SELMODRAFT_57580

Organism
Selaginella moellendorffii (Spikemoss)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterUniRule annotationNote: Binds 1 [2Fe-2S] cluster.UniRule annotation
  • [3Fe-4S] clusterUniRule annotationNote: Binds 1 [3Fe-4S] cluster.UniRule annotation
  • [4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SELMODRAFT_417854), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SELMODRAFT_118126), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SELMODRAFT_47515), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SELMODRAFT_126628), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SELMODRAFT_440964), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SELMODRAFT_82638), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SELMODRAFT_108358), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SELMODRAFT_57433), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SELMODRAFT_86191), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SELMODRAFT_57580), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SELMODRAFT_446158)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Ligand2Fe-2SUniRule annotation, 3Fe-4SUniRule annotation, 4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:SELMODRAFT_57580Imported
OrganismiSelaginella moellendorffii (Spikemoss)Imported
Taxonomic identifieri88036 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaLycopodiopsidaSelaginellalesSelaginellaceaeSelaginella
Proteomesi
  • UP000001514 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi88036.EFJ19143

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 972Fe-2S ferredoxin-typeInterPro annotationAdd BLAST92
Domaini140 – 1704Fe-4S ferredoxin-typeInterPro annotationAdd BLAST31

Sequence similaritiesi

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3049 Eukaryota
COG0479 LUCA
InParanoidiD8S953
KOiK00235
OMAiIDSRDMA
OrthoDBiEOG093609RV

Family and domain databases

CDDicd00207 fer2, 1 hit
Gene3Di1.10.1060.10, 1 hit
3.10.20.30, 1 hit
InterProiView protein in InterPro
IPR036010 2Fe-2S_ferredoxin-like_sf
IPR001041 2Fe-2S_ferredoxin-type
IPR006058 2Fe2S_fd_BS
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR012675 Beta-grasp_dom_sf
IPR009051 Helical_ferredxn
IPR004489 Succ_DH/fum_Rdtase_Fe-S
IPR025192 Succ_DH/fum_Rdtase_N
PfamiView protein in Pfam
PF13085 Fer2_3, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
SSF54292 SSF54292, 1 hit
TIGRFAMsiTIGR00384 dhsB, 1 hit
PROSITEiView protein in PROSITE
PS00197 2FE2S_FER_1, 1 hit
PS51085 2FE2S_FER_2, 1 hit
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 1 hit

Sequencei

Sequence statusi: Fragment.

D8S953-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KSSNIKEFSI YRWNPDGSSN PQQQVYKIDL NECGPMVLDA LIKIKNEVDQ
60 70 80 90 100
GLTFRRSCRE GICGSCAMNI NGKNGLACLT KIEKDAAQTS VLPLPHMYVI
110 120 130 140 150
KDLVVDLTNF YQQYKSVEPW LKTKTMLEAG QKEHLQSKKE RLKLDGMYEC
160 170 180 190 200
ILCACCTSSC PSYWWNPEKF LGPAALLHAH RWIADSRDEY TRERLEAIAG
210 220 230
DYKVGRCHTI RNCENACPKG LSPANQIIKI KALQ
Length:234
Mass (Da):26,550
Last modified:October 5, 2010 - v1
Checksum:iFFA4F7A3C88D9C69
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei234Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL377607 Genomic DNA Translation: EFJ19143.1
RefSeqiXP_002979741.1, XM_002979695.1

Genome annotation databases

EnsemblPlantsiEFJ19143; EFJ19143; SELMODRAFT_57580
GeneIDi9636198
GrameneiEFJ19143; EFJ19143; SELMODRAFT_57580
KEGGismo:SELMODRAFT_57580

Similar proteinsi

Entry informationi

Entry nameiD8S953_SELML
AccessioniPrimary (citable) accession number: D8S953
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: March 28, 2018
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health