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Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

SELMODRAFT_121442

Organism
Selaginella moellendorffii (Spikemoss)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Acetyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-acetyldihydrolipoyl)lysine.UniRule annotation

Cofactori

(R)-lipoateUniRule annotationNote: Binds 1 lipoyl cofactor covalently.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotation, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
Gene namesi
ORF Names:SELMODRAFT_121442Imported, SELMODRAFT_94277Imported
OrganismiSelaginella moellendorffii (Spikemoss)Imported
Taxonomic identifieri88036 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaLycopodiopsidaSelaginellalesSelaginellaceaeSelaginella
Proteomesi
  • UP000001514 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Mitochondrion matrix UniRule annotation

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_501082995417 – 446Acetyltransferase component of pyruvate dehydrogenase complexSequence analysisAdd BLAST430

Interactioni

Protein-protein interaction databases

STRINGi88036.EFJ28117.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 99Lipoyl-bindingInterPro annotationAdd BLAST77

Sequence similaritiesi

Belongs to the 2-oxoacid dehydrogenase family.UniRule annotation

Keywords - Domaini

LipoylUniRule annotation, SignalSequence analysis

Phylogenomic databases

eggNOGiKOG0557. Eukaryota.
COG0508. LUCA.
KOiK00627.
OMAiSWRLGCD.
OrthoDBiEOG093607WT.

Family and domain databases

Gene3Di4.10.320.10. 1 hit.
InterProiView protein in InterPro
IPR003016. 2-oxoA_DH_lipoyl-BS.
IPR001078. 2-oxoacid_DH_actylTfrase.
IPR000089. Biotin_lipoyl.
IPR004167. E3-bd.
IPR006257. LAT1.
IPR011053. Single_hybrid_motif.
PfamiView protein in Pfam
PF00198. 2-oxoacid_dh. 1 hit.
PF00364. Biotin_lipoyl. 1 hit.
PF02817. E3_binding. 1 hit.
SUPFAMiSSF47005. SSF47005. 1 hit.
SSF51230. SSF51230. 1 hit.
TIGRFAMsiTIGR01349. PDHac_trf_mito. 1 hit.
PROSITEiView protein in PROSITE
PS50968. BIOTINYL_LIPOYL. 1 hit.
PS00189. LIPOYL. 1 hit.

Sequencei

Sequence statusi: Complete.

D8RIN1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLFLSILCL TDHVFFSCLV PSHQPLGMPS LSPTMTQGNI VKWKKKEGDK
60 70 80 90 100
VTAGDVLCEI ETDKATVDME CMEDGYLAKI VFSDGAKDIK VGQIIAITVE
110 120 130 140 150
EQGDIDKFKD YKADAPAAPP KPAPKESPPP PKPTESPKPA PSPKPAPAAS
160 170 180 190 200
GDRIIASPNA RKYAQDNQIS LSGVAGTGPG GRIVRADLLI VVFIGGQQVQ
210 220 230 240 250
EPRRAETPGD STSLDYTDLP NTQIRRVIAQ RLLQSKQTIP HYYLTVDVRV
260 270 280 290 300
DKLLALRTQL NAKLEKEKRK KLSVNDFVLK AAALALKKVP ECNSSWTDEF
310 320 330 340 350
IRQFHNINIS VAVQTERGLM VPVVKDADKK GLGAISDDVR TLAEKARENT
360 370 380 390 400
LKPSDYDGGT FTVSNLGGPF GIKQFCAIIN PPQSCILAVG TTDKRVIPGE
410 420 430 440
NDGEYTAATF MSATLSCDHR VVDGAIGAHW LGAFKGYIED PMTLLL
Length:446
Mass (Da):48,348
Last modified:October 5, 2010 - v1
Checksum:iC3C1AEEA63F986D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GL377630 Genomic DNA. Translation: EFJ13978.1.
GL377580 Genomic DNA. Translation: EFJ28117.1.
RefSeqiXP_002970791.1. XM_002970745.1.
XP_002985103.1. XM_002985057.1.
UniGeneiSmo.15286.
Smo.2571.

Genome annotation databases

EnsemblPlantsiEFJ13978; EFJ13978; SELMODRAFT_121442.
EFJ28117; EFJ28117; SELMODRAFT_94277.
GeneIDi9641347.
9648948.
GrameneiEFJ13978; EFJ13978; SELMODRAFT_121442.
EFJ28117; EFJ28117; SELMODRAFT_94277.
KEGGismo:SELMODRAFT_121442.
smo:SELMODRAFT_94277.

Similar proteinsi

Entry informationi

Entry nameiD8RIN1_SELML
AccessioniPrimary (citable) accession number: D8RIN1
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: August 30, 2017
This is version 43 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported