ID   D8Q886_SCHCM            Unreviewed;       662 AA.
AC   D8Q886;
DT   05-OCT-2010, integrated into UniProtKB/TrEMBL.
DT   05-OCT-2010, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   RecName: Full=Acetyl-coenzyme A synthetase {ECO:0000256|RuleBase:RU361147};
DE            EC=6.2.1.1 {ECO:0000256|RuleBase:RU361147};
GN   ORFNames=SCHCODRAFT_77294 {ECO:0000313|EMBL:EFI96559.1};
OS   Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Schizophyllaceae; Schizophyllum.
OX   NCBI_TaxID=578458 {ECO:0000313|Proteomes:UP000007431};
RN   [1] {ECO:0000313|EMBL:EFI96559.1, ECO:0000313|Proteomes:UP000007431}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=H4-8 / FGSC 9210 {ECO:0000313|Proteomes:UP000007431};
RX   PubMed=20622885; DOI=10.1038/nbt.1643;
RA   Ohm R.A., de Jong J.F., Lugones L.G., Aerts A., Kothe E., Stajich J.E.,
RA   de Vries R.P., Record E., Levasseur A., Baker S.E., Bartholomew K.A.,
RA   Coutinho P.M., Erdmann S., Fowler T.J., Gathman A.C., Lombard V.,
RA   Henrissat B., Knabe N., Kuees U., Lilly W.W., Lindquist E., Lucas S.,
RA   Magnuson J.K., Piumi F., Raudaskoski M., Salamov A., Schmutz J.,
RA   Schwarze F.W.M.R., vanKuyk P.A., Horton J.S., Grigoriev I.V.,
RA   Woesten H.A.B.;
RT   "Genome sequence of the model mushroom Schizophyllum commune.";
RL   Nat. Biotechnol. 28:957-963(2010).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate;
CC         Xref=Rhea:RHEA:23176, ChEBI:CHEBI:30089, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288,
CC         ChEBI:CHEBI:456215; EC=6.2.1.1;
CC         Evidence={ECO:0000256|RuleBase:RU361147};
CC   -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC       {ECO:0000256|ARBA:ARBA00006432, ECO:0000256|RuleBase:RU361147}.
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DR   EMBL; GL377307; EFI96559.1; -; Genomic_DNA.
DR   RefSeq; XP_003031462.1; XM_003031416.1.
DR   AlphaFoldDB; D8Q886; -.
DR   STRING; 578458.D8Q886; -.
DR   GeneID; 9592576; -.
DR   KEGG; scm:SCHCO_02628260; -.
DR   VEuPathDB; FungiDB:SCHCODRAFT_02628260; -.
DR   eggNOG; KOG1175; Eukaryota.
DR   HOGENOM; CLU_000022_3_6_1; -.
DR   InParanoid; D8Q886; -.
DR   OMA; INVSYNC; -.
DR   OrthoDB; 144557at2759; -.
DR   Proteomes; UP000007431; Unassembled WGS sequence.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR   CDD; cd05966; ACS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR011904; Ac_CoA_lig.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU361147};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU361147};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW   ECO:0000256|RuleBase:RU361147};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007431}.
FT   DOMAIN          39..90
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          92..479
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          540..622
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   662 AA;  72535 MW;  84914B7A4955DECB CRC64;
     MAEAEQVPIH PVAPRLASKG TKKPHIGPHI HAYRTAHAET VGKESDKWWA KMAHEMLHWD
     RPFQTVRSGG FETGDIAWFP EGGLNASYNC VDRWAFKHPD KTAIIYEADE PGDGCTVSYA
     ELLRETCSVA NVLKGLGVKK GDAVSIYLPM TWHAVAAFLA CARIGAVHSV VFAGFSAESL
     RDRVLDCGSR VVITSDEGRR GGKTIATKAI VDAALKECPA VEHVVVLKRT GNDVAWTEGR
     DIWWHEETAK VPNYCPPEIM ASEDPLFILY TSGSTGKPKG VVHTTGGYLL GAAMTVKYVF
     DVHPDDKFAC MADIGWITGH TYIVYGPLAN GVSTTVFEST PVYPTPSRYW QTVEKHKLTQ
     FYSAPTAIRL LRRLGSHHVE NHDLSSLRVL GSVGEPINPE AWNWYNEHVG KMECAIVDTF
     WQTETGSIVV TPFPGAIETK PGAATVPFFG IEPAILDPVS GKELEGNNVE GVLAIKSPWP
     SIARTVYQDH NRYLETYMKP YPGYFYTGDG AARDEHGYIW IKGRVDDVIN VSGHRLSTAE
     IESALLLHKG VAETAVIGTP DELTGQAVYA FVTLKPEFAY DPADESSLVK ELVIQVRKVI
     GPFAAPKKIY IVADLPKTRS GKIMRRIMRK IVAGEGDQLG DLSTVADPGI VDVIKNKVAE
     SA
//