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D8PR70

- MAP2_SCHCM

UniProt

D8PR70 - MAP2_SCHCM

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Protein

Methionine aminopeptidase 2

Gene

SCHCODRAFT_64644

Organism
Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei176 – 1761SubstrateUniRule annotation
Metal bindingi196 – 1961Divalent metal cation 1UniRule annotation
Metal bindingi207 – 2071Divalent metal cation 1UniRule annotation
Metal bindingi207 – 2071Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi276 – 2761Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation
Binding sitei284 – 2841SubstrateUniRule annotation
Metal bindingi309 – 3091Divalent metal cation 2; catalyticUniRule annotation
Metal bindingi404 – 4041Divalent metal cation 1UniRule annotation
Metal bindingi404 – 4041Divalent metal cation 2; catalyticUniRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2UniRule annotation (EC:3.4.11.18UniRule annotation)
Short name:
MAP 2UniRule annotation
Short name:
MetAP 2UniRule annotation
Alternative name(s):
Peptidase MUniRule annotation
Gene namesi
ORF Names:SCHCODRAFT_64644
OrganismiSchizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus)
Taxonomic identifieri578458 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesSchizophyllaceaeSchizophyllum
ProteomesiUP000007431: Unassembled WGS sequence

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Methionine aminopeptidase 2PRO_0000407667Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliD8PR70.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 5414Lys-richAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.UniRule annotation

Phylogenomic databases

InParanoidiD8PR70.
KOiK01265.
OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10804:SF9. PTHR10804:SF9. 1 hit.
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.

Sequencei

Sequence statusi: Complete.

D8PR70-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTDVIDAKPE EAKKVPPEVE DEDSGDESAP EASAAGGEAT KKKKKKKKPK
60 70 80 90 100
KKKKAAEQSE PPRVGLSKLF PNGIYPEGEI QPYKDDNAYR TTSEEKRYLE
110 120 130 140 150
RITCEDPDET YQNIRKGAEV HRQVRQYAQR TIKPGMTMTE IANLIEDGTR
160 170 180 190 200
ALVEENGLEA GIGFPTGLSL NNCAAHYTPN AGDTIVLQQG DVMKVDIGVQ
210 220 230 240 250
VKGRIVDSAF TMTFEPTYDK LLEAVRAATN TGIREAGIDA RLGEIAGAIQ
260 270 280 290 300
ETMESYEVEV NGKLIPVKPI ANLSGHSIDR YTIHAGKSVC LVKNDDQTKM
310 320 330 340 350
EEGEYFAIET FGSTGRGRVV DGGECSHYAR KVDAPHVPLR LTTAKSLLKS
360 370 380 390 400
INKNFGTIPF CRRYLDRIGE SKYLLALNHL VQQGIVEDYP PLYDQQGSMT
410 420
AQFEHTILLR PTVKEVVSRG DDY
Length:423
Mass (Da):46,783
Last modified:October 5, 2010 - v1
Checksum:i3680863E582C4A34
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL377302 Genomic DNA. Translation: EFJ03808.1.
RefSeqiXP_003038710.1. XM_003038664.1.

Genome annotation databases

GeneIDi9592388.
KEGGiscm:SCHCODRAFT_64644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL377302 Genomic DNA. Translation: EFJ03808.1 .
RefSeqi XP_003038710.1. XM_003038664.1.

3D structure databases

ProteinModelPortali D8PR70.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9592388.
KEGGi scm:SCHCODRAFT_64644.

Phylogenomic databases

InParanoidi D8PR70.
KOi K01265.
OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10804:SF9. PTHR10804:SF9. 1 hit.
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H4-8 / FGSC 9210.

Entry informationi

Entry nameiMAP2_SCHCM
AccessioniPrimary (citable) accession number: D8PR70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: October 5, 2010
Last modified: October 29, 2014
This is version 27 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3