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D8PR70

- MAP2_SCHCM

UniProt

D8PR70 - MAP2_SCHCM

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Protein
Methionine aminopeptidase 2
Gene
SCHCODRAFT_64644
Organism
Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) By similarity.UniRule annotation

Catalytic activityi

Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

Cofactori

Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei176 – 1761Substrate By similarity
Metal bindingi196 – 1961Divalent metal cation 1 By similarity
Metal bindingi207 – 2071Divalent metal cation 1 By similarity
Metal bindingi207 – 2071Divalent metal cation 2; catalytic By similarity
Metal bindingi276 – 2761Divalent metal cation 2; catalytic; via tele nitrogen By similarity
Binding sitei284 – 2841Substrate By similarity
Metal bindingi309 – 3091Divalent metal cation 2; catalytic By similarity
Metal bindingi404 – 4041Divalent metal cation 1 By similarity
Metal bindingi404 – 4041Divalent metal cation 2; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-HAMAP
  2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein initiator methionine removal Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Protease

Keywords - Ligandi

Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Methionine aminopeptidase 2 (EC:3.4.11.18)
Short name:
MAP 2
Short name:
MetAP 2
Alternative name(s):
Peptidase M
Gene namesi
ORF Names:SCHCODRAFT_64644
OrganismiSchizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus)
Taxonomic identifieri578458 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesSchizophyllaceaeSchizophyllum
ProteomesiUP000007431: Unassembled WGS sequence

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423Methionine aminopeptidase 2UniRule annotation
PRO_0000407667Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliD8PR70.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi41 – 5414Lys-richUniRule annotation
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

KOiK01265.
OrthoDBiEOG7BGHW3.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPiMF_03175. MetAP_2_euk.
InterProiIPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR10804:SF9. PTHR10804:SF9. 1 hit.
PfamiPF00557. Peptidase_M24. 1 hit.
[Graphical view]
PRINTSiPR00599. MAPEPTIDASE.
SUPFAMiSSF55920. SSF55920. 2 hits.
TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.

Sequencei

Sequence statusi: Complete.

D8PR70-1 [UniParc]FASTAAdd to Basket

« Hide

MTDVIDAKPE EAKKVPPEVE DEDSGDESAP EASAAGGEAT KKKKKKKKPK    50
KKKKAAEQSE PPRVGLSKLF PNGIYPEGEI QPYKDDNAYR TTSEEKRYLE 100
RITCEDPDET YQNIRKGAEV HRQVRQYAQR TIKPGMTMTE IANLIEDGTR 150
ALVEENGLEA GIGFPTGLSL NNCAAHYTPN AGDTIVLQQG DVMKVDIGVQ 200
VKGRIVDSAF TMTFEPTYDK LLEAVRAATN TGIREAGIDA RLGEIAGAIQ 250
ETMESYEVEV NGKLIPVKPI ANLSGHSIDR YTIHAGKSVC LVKNDDQTKM 300
EEGEYFAIET FGSTGRGRVV DGGECSHYAR KVDAPHVPLR LTTAKSLLKS 350
INKNFGTIPF CRRYLDRIGE SKYLLALNHL VQQGIVEDYP PLYDQQGSMT 400
AQFEHTILLR PTVKEVVSRG DDY 423
Length:423
Mass (Da):46,783
Last modified:October 5, 2010 - v1
Checksum:i3680863E582C4A34
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL377302 Genomic DNA. Translation: EFJ03808.1.
RefSeqiXP_003038710.1. XM_003038664.1.

Genome annotation databases

GeneIDi9592388.
KEGGiscm:SCHCODRAFT_64644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GL377302 Genomic DNA. Translation: EFJ03808.1 .
RefSeqi XP_003038710.1. XM_003038664.1.

3D structure databases

ProteinModelPortali D8PR70.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9592388.
KEGGi scm:SCHCODRAFT_64644.

Phylogenomic databases

KOi K01265.
OrthoDBi EOG7BGHW3.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
3.90.230.10. 2 hits.
HAMAPi MF_03175. MetAP_2_euk.
InterProi IPR001714. Pept_M24_MAP.
IPR000994. Pept_M24_structural-domain.
IPR002468. Pept_M24A_MAP2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
PANTHERi PTHR10804:SF9. PTHR10804:SF9. 1 hit.
Pfami PF00557. Peptidase_M24. 1 hit.
[Graphical view ]
PRINTSi PR00599. MAPEPTIDASE.
SUPFAMi SSF55920. SSF55920. 2 hits.
TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: H4-8 / FGSC 9210.

Entry informationi

Entry nameiMAP2_SCHCM
AccessioniPrimary (citable) accession number: D8PR70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 3, 2011
Last sequence update: October 5, 2010
Last modified: May 14, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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