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D8PR70

- MAP2_SCHCM

UniProt

D8PR70 - MAP2_SCHCM

Protein

Methionine aminopeptidase 2

Gene

SCHCODRAFT_64644

Organism
Schizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 26 (01 Oct 2014)
      Sequence version 1 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).UniRule annotation

    Catalytic activityi

    Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.UniRule annotation

    Cofactori

    Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe2+-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei176 – 1761SubstrateUniRule annotation
    Metal bindingi196 – 1961Divalent metal cation 1UniRule annotation
    Metal bindingi207 – 2071Divalent metal cation 1UniRule annotation
    Metal bindingi207 – 2071Divalent metal cation 2; catalyticUniRule annotation
    Metal bindingi276 – 2761Divalent metal cation 2; catalytic; via tele nitrogenUniRule annotation
    Binding sitei284 – 2841SubstrateUniRule annotation
    Metal bindingi309 – 3091Divalent metal cation 2; catalyticUniRule annotation
    Metal bindingi404 – 4041Divalent metal cation 1UniRule annotation
    Metal bindingi404 – 4041Divalent metal cation 2; catalyticUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-HAMAP
    2. metalloaminopeptidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. protein initiator methionine removal Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Protease

    Keywords - Ligandi

    Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methionine aminopeptidase 2UniRule annotation (EC:3.4.11.18UniRule annotation)
    Short name:
    MAP 2UniRule annotation
    Short name:
    MetAP 2UniRule annotation
    Alternative name(s):
    Peptidase MUniRule annotation
    Gene namesi
    ORF Names:SCHCODRAFT_64644
    OrganismiSchizophyllum commune (strain H4-8 / FGSC 9210) (Split gill fungus)
    Taxonomic identifieri578458 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesSchizophyllaceaeSchizophyllum
    ProteomesiUP000007431: Unassembled WGS sequence

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 423423Methionine aminopeptidase 2PRO_0000407667Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliD8PR70.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi41 – 5414Lys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.UniRule annotation

    Phylogenomic databases

    KOiK01265.
    OrthoDBiEOG7BGHW3.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    3.90.230.10. 2 hits.
    HAMAPiMF_03175. MetAP_2_euk.
    InterProiIPR001714. Pept_M24_MAP.
    IPR000994. Pept_M24_structural-domain.
    IPR002468. Pept_M24A_MAP2.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PANTHERiPTHR10804:SF9. PTHR10804:SF9. 1 hit.
    PfamiPF00557. Peptidase_M24. 1 hit.
    [Graphical view]
    PRINTSiPR00599. MAPEPTIDASE.
    SUPFAMiSSF55920. SSF55920. 2 hits.
    TIGRFAMsiTIGR00501. met_pdase_II. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    D8PR70-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTDVIDAKPE EAKKVPPEVE DEDSGDESAP EASAAGGEAT KKKKKKKKPK    50
    KKKKAAEQSE PPRVGLSKLF PNGIYPEGEI QPYKDDNAYR TTSEEKRYLE 100
    RITCEDPDET YQNIRKGAEV HRQVRQYAQR TIKPGMTMTE IANLIEDGTR 150
    ALVEENGLEA GIGFPTGLSL NNCAAHYTPN AGDTIVLQQG DVMKVDIGVQ 200
    VKGRIVDSAF TMTFEPTYDK LLEAVRAATN TGIREAGIDA RLGEIAGAIQ 250
    ETMESYEVEV NGKLIPVKPI ANLSGHSIDR YTIHAGKSVC LVKNDDQTKM 300
    EEGEYFAIET FGSTGRGRVV DGGECSHYAR KVDAPHVPLR LTTAKSLLKS 350
    INKNFGTIPF CRRYLDRIGE SKYLLALNHL VQQGIVEDYP PLYDQQGSMT 400
    AQFEHTILLR PTVKEVVSRG DDY 423
    Length:423
    Mass (Da):46,783
    Last modified:October 5, 2010 - v1
    Checksum:i3680863E582C4A34
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL377302 Genomic DNA. Translation: EFJ03808.1.
    RefSeqiXP_003038710.1. XM_003038664.1.

    Genome annotation databases

    GeneIDi9592388.
    KEGGiscm:SCHCODRAFT_64644.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    GL377302 Genomic DNA. Translation: EFJ03808.1 .
    RefSeqi XP_003038710.1. XM_003038664.1.

    3D structure databases

    ProteinModelPortali D8PR70.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9592388.
    KEGGi scm:SCHCODRAFT_64644.

    Phylogenomic databases

    KOi K01265.
    OrthoDBi EOG7BGHW3.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    3.90.230.10. 2 hits.
    HAMAPi MF_03175. MetAP_2_euk.
    InterProi IPR001714. Pept_M24_MAP.
    IPR000994. Pept_M24_structural-domain.
    IPR002468. Pept_M24A_MAP2.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    PANTHERi PTHR10804:SF9. PTHR10804:SF9. 1 hit.
    Pfami PF00557. Peptidase_M24. 1 hit.
    [Graphical view ]
    PRINTSi PR00599. MAPEPTIDASE.
    SUPFAMi SSF55920. SSF55920. 2 hits.
    TIGRFAMsi TIGR00501. met_pdase_II. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: H4-8 / FGSC 9210.

    Entry informationi

    Entry nameiMAP2_SCHCM
    AccessioniPrimary (citable) accession number: D8PR70
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 26 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3