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D8PGT0

- D8PGT0_9BACT

UniProt

D8PGT0 - D8PGT0_9BACT

Protein

Alanine racemase

Gene

alr

Organism
Candidatus Nitrospira defluvii
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (05 Oct 2010)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei138 – 1381SubstrateUniRule annotation
    Active sitei267 – 2671Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei315 – 3151Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciNDEF330214:GI4U-2715-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alrImported
    ORF Names:NIDE2761Imported
    OrganismiCandidatus Nitrospira defluviiImported
    Taxonomic identifieri330214 [NCBI]
    Taxonomic lineageiBacteriaNitrospiraeNitrospiralesNitrospiraceaeNitrospira
    ProteomesiUP000001660: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliD8PGT0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000031444.
    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D8PGT0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYTPSQFPPT SVSVDLNALG HNLAHVRRLA PRSEVLAVVK ANAYGHGALE    50
    LTRTLQQLAV HRFGVATVDE GIVLRQAGIH DPILVMGPTV PAQFPDLIAH 100
    RLTPVLYRSD MVQAFAAAVP PKAAPYSVHV KIETGMGRLG VHPPEMPDLA 150
    AMPAFRATLR LEGLMTHLAD ADNTKTTHTE TQLTEFQQTL DTLRQGGLSC 200
    PLIHAANSAG IIQYPASLYT LVRPGIMLYG YHTLSNETPA PELRPILTWK 250
    ATIAHLHNIQ AGDSVSYNRT FIAARRSKIA VLPVGYADGY NRLLSNRGMV 300
    LIGGRRVPVV GRVCMDMTMV DVTDVPGVHI GQEAILIGQQ GQERLTAADL 350
    AAWQQTIPYE VLCAIGQRVP RHYLPLRSDN EKSSPKP 387
    Length:387
    Mass (Da):42,140
    Last modified:October 5, 2010 - v1
    Checksum:i5DDD96A5DA66AA5A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP929003 Genomic DNA. Translation: CBK42467.1.
    RefSeqiWP_013249288.1. NC_014355.1.
    YP_003798392.1. NC_014355.1.

    Genome annotation databases

    EnsemblBacteriaiCBK42467; CBK42467; NIDE2761.
    GeneIDi9486037.
    KEGGinde:NIDE2761.
    PATRICi42244483. VBICanNit28252_2622.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP929003 Genomic DNA. Translation: CBK42467.1 .
    RefSeqi WP_013249288.1. NC_014355.1.
    YP_003798392.1. NC_014355.1.

    3D structure databases

    ProteinModelPortali D8PGT0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBK42467 ; CBK42467 ; NIDE2761 .
    GeneIDi 9486037.
    KEGGi nde:NIDE2761.
    PATRICi 42244483. VBICanNit28252_2622.

    Phylogenomic databases

    HOGENOMi HOG000031444.
    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci NDEF330214:GI4U-2715-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria."
      Lucker S., Wagner M., Maixner F., Pelletier E., Koch H., Vacherie B., Rattei T., Sinninghe Damste J., Spieck E., Le Paslier D., Daims H.
      Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2010)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiD8PGT0_9BACT
    AccessioniPrimary (citable) accession number: D8PGT0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3