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Protein

Alanine racemase

Gene

alr

Organism
Candidatus Nitrospira defluvii
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathway: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei138 – 1381SubstrateUniRule annotation
Active sitei267 – 2671Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei315 – 3151Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciNDEF330214:GI4U-2715-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
ORF Names:NIDE2761Imported
OrganismiCandidatus Nitrospira defluviiImported
Taxonomic identifieri330214 [NCBI]
Taxonomic lineageiBacteriaNitrospiraeNitrospiralesNitrospiraceaeNitrospira
ProteomesiUP000001660 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi330214.NIDE2761.

Structurei

3D structure databases

ProteinModelPortaliD8PGT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8PGT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTPSQFPPT SVSVDLNALG HNLAHVRRLA PRSEVLAVVK ANAYGHGALE
60 70 80 90 100
LTRTLQQLAV HRFGVATVDE GIVLRQAGIH DPILVMGPTV PAQFPDLIAH
110 120 130 140 150
RLTPVLYRSD MVQAFAAAVP PKAAPYSVHV KIETGMGRLG VHPPEMPDLA
160 170 180 190 200
AMPAFRATLR LEGLMTHLAD ADNTKTTHTE TQLTEFQQTL DTLRQGGLSC
210 220 230 240 250
PLIHAANSAG IIQYPASLYT LVRPGIMLYG YHTLSNETPA PELRPILTWK
260 270 280 290 300
ATIAHLHNIQ AGDSVSYNRT FIAARRSKIA VLPVGYADGY NRLLSNRGMV
310 320 330 340 350
LIGGRRVPVV GRVCMDMTMV DVTDVPGVHI GQEAILIGQQ GQERLTAADL
360 370 380
AAWQQTIPYE VLCAIGQRVP RHYLPLRSDN EKSSPKP
Length:387
Mass (Da):42,140
Last modified:October 5, 2010 - v1
Checksum:i5DDD96A5DA66AA5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP929003 Genomic DNA. Translation: CBK42467.1.
RefSeqiWP_013249288.1. NC_014355.1.
YP_003798392.1. NC_014355.1.

Genome annotation databases

EnsemblBacteriaiCBK42467; CBK42467; NIDE2761.
KEGGinde:NIDE2761.
PATRICi42244483. VBICanNit28252_2622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP929003 Genomic DNA. Translation: CBK42467.1.
RefSeqiWP_013249288.1. NC_014355.1.
YP_003798392.1. NC_014355.1.

3D structure databases

ProteinModelPortaliD8PGT0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi330214.NIDE2761.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBK42467; CBK42467; NIDE2761.
KEGGinde:NIDE2761.
PATRICi42244483. VBICanNit28252_2622.

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciNDEF330214:GI4U-2715-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria."
    Lucker S., Wagner M., Maixner F., Pelletier E., Koch H., Vacherie B., Rattei T., Sinninghe Damste J., Spieck E., Le Paslier D., Daims H.
    Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2010)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiD8PGT0_9BACT
AccessioniPrimary (citable) accession number: D8PGT0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: June 24, 2015
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.