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D8PGT0

- D8PGT0_9BACT

UniProt

D8PGT0 - D8PGT0_9BACT

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Protein

Alanine racemase

Gene

alr

Organism
Candidatus Nitrospira defluvii
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei40 – 401Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei138 – 1381SubstrateUniRule annotation
Active sitei267 – 2671Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei315 – 3151Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciNDEF330214:GI4U-2715-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
ORF Names:NIDE2761Imported
OrganismiCandidatus Nitrospira defluviiImported
Taxonomic identifieri330214 [NCBI]
Taxonomic lineageiBacteriaNitrospiraeNitrospiralesNitrospiraceaeNitrospira
ProteomesiUP000001660: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei40 – 401N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliD8PGT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000031444.
KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8PGT0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MYTPSQFPPT SVSVDLNALG HNLAHVRRLA PRSEVLAVVK ANAYGHGALE
60 70 80 90 100
LTRTLQQLAV HRFGVATVDE GIVLRQAGIH DPILVMGPTV PAQFPDLIAH
110 120 130 140 150
RLTPVLYRSD MVQAFAAAVP PKAAPYSVHV KIETGMGRLG VHPPEMPDLA
160 170 180 190 200
AMPAFRATLR LEGLMTHLAD ADNTKTTHTE TQLTEFQQTL DTLRQGGLSC
210 220 230 240 250
PLIHAANSAG IIQYPASLYT LVRPGIMLYG YHTLSNETPA PELRPILTWK
260 270 280 290 300
ATIAHLHNIQ AGDSVSYNRT FIAARRSKIA VLPVGYADGY NRLLSNRGMV
310 320 330 340 350
LIGGRRVPVV GRVCMDMTMV DVTDVPGVHI GQEAILIGQQ GQERLTAADL
360 370 380
AAWQQTIPYE VLCAIGQRVP RHYLPLRSDN EKSSPKP
Length:387
Mass (Da):42,140
Last modified:October 5, 2010 - v1
Checksum:i5DDD96A5DA66AA5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP929003 Genomic DNA. Translation: CBK42467.1.
RefSeqiWP_013249288.1. NC_014355.1.
YP_003798392.1. NC_014355.1.

Genome annotation databases

EnsemblBacteriaiCBK42467; CBK42467; NIDE2761.
GeneIDi9486037.
KEGGinde:NIDE2761.
PATRICi42244483. VBICanNit28252_2622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP929003 Genomic DNA. Translation: CBK42467.1 .
RefSeqi WP_013249288.1. NC_014355.1.
YP_003798392.1. NC_014355.1.

3D structure databases

ProteinModelPortali D8PGT0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBK42467 ; CBK42467 ; NIDE2761 .
GeneIDi 9486037.
KEGGi nde:NIDE2761.
PATRICi 42244483. VBICanNit28252_2622.

Phylogenomic databases

HOGENOMi HOG000031444.
KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci NDEF330214:GI4U-2715-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria."
    Lucker S., Wagner M., Maixner F., Pelletier E., Koch H., Vacherie B., Rattei T., Sinninghe Damste J., Spieck E., Le Paslier D., Daims H.
    Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2010)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiD8PGT0_9BACT
AccessioniPrimary (citable) accession number: D8PGT0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 26, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3