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Protein

Alanine racemase

Gene

alr

Organism
Nitrospira defluvii
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (alr)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei40Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei138SubstrateUniRule annotation1
Active sitei267Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei315Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
ORF Names:NIDE2761Imported
OrganismiNitrospira defluviiImported
Taxonomic identifieri330214 [NCBI]
Taxonomic lineageiBacteriaNitrospiraeNitrospiralesNitrospiraceaeNitrospira
Proteomesi
  • UP000001660 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei40N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi330214.NIDE2761.

Structurei

3D structure databases

ProteinModelPortaliD8PGT0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini246 – 374Ala_racemase_CInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4. Bacteria.
COG0787. LUCA.
HOGENOMiHOG000031444.
KOiK01775.
OrthoDBiPOG091H022F.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase. 1 hit.
InterProiView protein in InterPro
IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
PfamiView protein in Pfam
PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
PRINTSiPR00992. ALARACEMASE.
SMARTiView protein in SMART
SM01005. Ala_racemase_C. 1 hit.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiView protein in PROSITE
PS00395. ALANINE_RACEMASE. 1 hit.

Sequencei

Sequence statusi: Complete.

D8PGT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYTPSQFPPT SVSVDLNALG HNLAHVRRLA PRSEVLAVVK ANAYGHGALE
60 70 80 90 100
LTRTLQQLAV HRFGVATVDE GIVLRQAGIH DPILVMGPTV PAQFPDLIAH
110 120 130 140 150
RLTPVLYRSD MVQAFAAAVP PKAAPYSVHV KIETGMGRLG VHPPEMPDLA
160 170 180 190 200
AMPAFRATLR LEGLMTHLAD ADNTKTTHTE TQLTEFQQTL DTLRQGGLSC
210 220 230 240 250
PLIHAANSAG IIQYPASLYT LVRPGIMLYG YHTLSNETPA PELRPILTWK
260 270 280 290 300
ATIAHLHNIQ AGDSVSYNRT FIAARRSKIA VLPVGYADGY NRLLSNRGMV
310 320 330 340 350
LIGGRRVPVV GRVCMDMTMV DVTDVPGVHI GQEAILIGQQ GQERLTAADL
360 370 380
AAWQQTIPYE VLCAIGQRVP RHYLPLRSDN EKSSPKP
Length:387
Mass (Da):42,140
Last modified:October 5, 2010 - v1
Checksum:i5DDD96A5DA66AA5A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP929003 Genomic DNA. Translation: CBK42467.1.
RefSeqiWP_013249288.1. NC_014355.1.

Genome annotation databases

EnsemblBacteriaiCBK42467; CBK42467; NIDE2761.
KEGGinde:NIDE2761.

Similar proteinsi

Entry informationi

Entry nameiD8PGT0_9BACT
AccessioniPrimary (citable) accession number: D8PGT0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 22, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported