D8PAD8 (D8PAD8_9BACT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Histidinol-phosphate aminotransferase HAMAP-Rule MF_01023
EC=2.6.1.9 HAMAP-Rule MF_01023

Alternative name(s):
Imidazole acetol-phosphate transaminase HAMAP-Rule MF_01023

Gene names

Name:	hisC HAMAP-Rule MF_01023 EMBL CBK40197.1
ORF Names:	NIDE0420 EMBL CBK40197.1

Organism

Candidatus Nitrospira defluvii EMBL CBK40197.1

Taxonomic identifier

330214 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Nitrospirae › Nitrospira › Nitrospirales › Nitrospiraceae › Nitrospira

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate. HAMAP-Rule MF_01023 SAAS SAAS005861
Cofactor	Pyridoxal phosphate By similarity. HAMAP-Rule MF_01023 SAAS SAAS005861
Pathway	Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. HAMAP-Rule MF_01023 SAAS SAAS005861
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_01023
Sequence similarities	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. HAMAP-Rule MF_01023

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Histidine biosynthesis HAMAP-Rule MF_01023 SAAS SAAS005861
Ligand	Pyridoxal phosphate HAMAP-Rule MF_01023 SAAS SAAS005861
Molecular function	Aminotransferase HAMAP-Rule MF_01023 SAAS SAAS005861 EMBL CBK40197.1 Transferase
Gene Ontology (GO)
Biological_process	histidine biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	L-phenylalanine:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC histidinol-phosphate transaminase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Amino acid modifications
	Modified residue	224	1	N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01023

Sequences

	Sequence		Length	Mass (Da)
	D8PAD8 [UniParc]. Last modified October 5, 2010. Version 1. Checksum: E324030227ABC3DA	FASTA	361	39,712
	10 20 30 40 50 60 MPLKVHPDIA SLVPYVPGKP IEELQRELGL PRAIKLASNE NPIGPSPKAL AVLSETAPTL 70 80 90 100 110 120 HRYPDGGAFR LRGALAERWK VTPDHVILGN GSDEILGLLA RTFLSPGDEA VMAEHTFVIY 130 140 150 160 170 180 KMEVKAAHGV AVEVPQKKWH HDLPAMAAAI TDKTRLLFVC NPNNPTGTMA TRDEVAALMA 190 200 210 220 230 240 RVPDHVVVVF DEAYYEYVRH AEFPESLDYV KAGRNAIVLR TFSKIYGLAG LRIGYGMTTP 250 260 270 280 290 300 EITNYLNRIR PPFNANSMAQ RAALAALDDE AHVGASRALN HAEMDKVRAG LLTLGFEALP 310 320 330 340 350 360 SETNFLYFDV GRDGREVFDA LLRKGIIVRH IDGRMLRVTI GLPEENQLFL SALADVTRAA R

References

[1]	"A Nitrospira metagenome illuminates the physiology and evolution of globally important nitrite-oxidizing bacteria." Lucker S., Wagner M., Maixner F., Pelletier E., Koch H., Vacherie B., Rattei T., Sinninghe Damste J., Spieck E., Le Paslier D., Daims H. Proc. Natl. Acad. Sci. U.S.A. 0:0-0(2010) Cited for: NUCLEOTIDE SEQUENCE.
[2]	Genoscope - CEA Submitted (MAR-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	FP929003 Genomic DNA. Translation: CBK40197.1.
RefSeq	YP_003796123.1. NC_014355.1.
3D structure databases
ProteinModelPortal	D8PAD8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CBK40197; CBK40197; NIDE0420.
GeneID	9486413.
KEGG	nde:NIDE0420.
PATRIC	42239977. VBICanNit28252_0389.
Phylogenomic databases
HOGENOM	HOG000288510.
KO	K00817.
Enzyme and pathway databases
BioCyc	NDEF330214:GI4U-417-MONOMER.
UniPathway	UPA00031; UER00012.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 1 hit.
HAMAP	MF_01023. HisC_aminotrans_2.
InterPro	IPR004839. Aminotransferase_I/II. IPR005861. HisP_aminotrans. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR01141. hisC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

D8PAD8_9BACT

Accession

Primary (citable) accession number: D8PAD8

Entry history

Integrated into UniProtKB/TrEMBL:	October 5, 2010
Last sequence update:	October 5, 2010
Last modified:	May 29, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)