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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Ralstonia solanacearum (Pseudomonas solanacearum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciRSOL859657:GJJ9-981-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotationImported)
Gene namesi
Name:icdImported
ORF Names:RPSI07_0976Imported
OrganismiRalstonia solanacearum (Pseudomonas solanacearum)Imported
Taxonomic identifieri305 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000006858 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi267608.RSc2490.

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8NZI3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYQHIKVPAG EKITVNQDFS LNVPDNPIIP YIEGDGTGFD ITPVMIKVVD
60 70 80 90 100
AAVAKAYAGK RKISWMEIYA GEKSTKVYGP DVWLPEETLQ VLKDYVVSIK
110 120 130 140 150
GPLTTPVGGG IRSLNVALRQ ELDLYVCLRP VRYFKGVPSP VREPEKTDMV
160 170 180 190 200
IFRENSEDIY AGIEWAAESE QAKKVIAFLR NEMGVKKIRF PETSGIGIKP
210 220 230 240 250
VSKEGTQRLV RKAIQYAIDN DKPSVTIVHK GNIMKFTEGG FRDWAYELAQ
260 270 280 290 300
KEFGAELIDG GPWCKFKNPK TGKDIIVKDA IADAFLQQIL LRPAEYSVVA
310 320 330 340 350
TLNLNGDYIS DALAAQVGGI GIAPGANLSD SVAMFEATHG TAPKYAGKDY
360 370 380 390 400
VNPGSEILSA EMMLRHMGWT EAADLIISSI EKSILSKKVT YDFARLLEGA
410
TQVSCSGFGQ VMIDNM
Length:416
Mass (Da):45,696
Last modified:October 5, 2010 - v1
Checksum:iCEBC39AEC915A5E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP885906 Genomic DNA. Translation: CBJ50336.1.

Genome annotation databases

EnsemblBacteriaiCBJ50336; CBJ50336; RPSI07_0976.
PATRICi42538081. VBIRalSol167236_2650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP885906 Genomic DNA. Translation: CBJ50336.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi267608.RSc2490.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBJ50336; CBJ50336; RPSI07_0976.
PATRICi42538081. VBIRalSol167236_2650.

Phylogenomic databases

HOGENOMiHOG000021113.

Enzyme and pathway databases

BioCyciRSOL859657:GJJ9-981-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomes of three tomato pathogens within the Ralstonia solanacearum species complex reveal significant evolutionary divergence."
    Remenant B., Coupat-Goutaland B., Guidot A., Cellier G., Wicker E., Allen C., Fegan M., Pruvost O., Elbaz M., Calteau A., Salvignol G., Mornico D., Mangenot S., Barbe V., Medigue C., Prior P.
    BMC Genomics 11:379-379(2010)
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PSI07Imported.

Entry informationi

Entry nameiD8NZI3_RALSL
AccessioniPrimary (citable) accession number: D8NZI3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: July 22, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.