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D8NZI3

- D8NZI3_RALSL

UniProt

D8NZI3 - D8NZI3_RALSL

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Ralstonia solanacearum (Pseudomonas solanacearum)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 25 (01 Oct 2014)
      Sequence version 1 (05 Oct 2010)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciRSOL859657:GJJ9-981-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdImported
    ORF Names:RPSI07_0976Imported
    OrganismiRalstonia solanacearum (Pseudomonas solanacearum)Imported
    Taxonomic identifieri305 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
    ProteomesiUP000006858: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    HOGENOMiHOG000021113.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    D8NZI3-1 [UniParc]FASTAAdd to Basket

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    MYQHIKVPAG EKITVNQDFS LNVPDNPIIP YIEGDGTGFD ITPVMIKVVD    50
    AAVAKAYAGK RKISWMEIYA GEKSTKVYGP DVWLPEETLQ VLKDYVVSIK 100
    GPLTTPVGGG IRSLNVALRQ ELDLYVCLRP VRYFKGVPSP VREPEKTDMV 150
    IFRENSEDIY AGIEWAAESE QAKKVIAFLR NEMGVKKIRF PETSGIGIKP 200
    VSKEGTQRLV RKAIQYAIDN DKPSVTIVHK GNIMKFTEGG FRDWAYELAQ 250
    KEFGAELIDG GPWCKFKNPK TGKDIIVKDA IADAFLQQIL LRPAEYSVVA 300
    TLNLNGDYIS DALAAQVGGI GIAPGANLSD SVAMFEATHG TAPKYAGKDY 350
    VNPGSEILSA EMMLRHMGWT EAADLIISSI EKSILSKKVT YDFARLLEGA 400
    TQVSCSGFGQ VMIDNM 416
    Length:416
    Mass (Da):45,696
    Last modified:October 5, 2010 - v1
    Checksum:iCEBC39AEC915A5E9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP885906 Genomic DNA. Translation: CBJ50336.1.

    Genome annotation databases

    EnsemblBacteriaiCBJ50336; CBJ50336; RPSI07_0976.
    PATRICi42538081. VBIRalSol167236_2650.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    FP885906 Genomic DNA. Translation: CBJ50336.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CBJ50336 ; CBJ50336 ; RPSI07_0976 .
    PATRICi 42538081. VBIRalSol167236_2650.

    Phylogenomic databases

    HOGENOMi HOG000021113.

    Enzyme and pathway databases

    BioCyci RSOL859657:GJJ9-981-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomes of three tomato pathogens within the Ralstonia solanacearum species complex reveal significant evolutionary divergence."
      Remenant B., Coupat-Goutaland B., Guidot A., Cellier G., Wicker E., Allen C., Fegan M., Pruvost O., Elbaz M., Calteau A., Salvignol G., Mornico D., Mangenot S., Barbe V., Medigue C., Prior P.
      BMC Genomics 11:379-379(2010)
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PSI07Imported.

    Entry informationi

    Entry nameiD8NZI3_RALSL
    AccessioniPrimary (citable) accession number: D8NZI3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 5, 2010
    Last sequence update: October 5, 2010
    Last modified: October 1, 2014
    This is version 25 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3