Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

3-deoxy-manno-octulosonate cytidylyltransferase

Gene

kdsB

Organism
Ralstonia solanacearum PSI07
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotation

Catalytic activityi

CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

Pathwayi: lipopolysaccharide biosynthesis

This protein is involved in the pathway lipopolysaccharide biosynthesis, which is part of Bacterial outer membrane biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway lipopolysaccharide biosynthesis and in Bacterial outer membrane biogenesis.

Pathwayi: CMP-3-deoxy-D-manno-octulosonate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. 3-deoxy-manno-octulosonate cytidylyltransferase (kdsB)
This subpathway is part of the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis, which is itself part of Nucleotide-sugar biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP, the pathway CMP-3-deoxy-D-manno-octulosonate biosynthesis and in Nucleotide-sugar biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferaseUniRule annotationSAAS annotationImported, Transferase
Biological processLipopolysaccharide biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00030
UPA00358; UER00476

Names & Taxonomyi

Protein namesi
Recommended name:
3-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotation (EC:2.7.7.38UniRule annotation)
Alternative name(s):
CMP-2-keto-3-deoxyoctulosonic acid synthaseUniRule annotation
Short name:
CKSUniRule annotation
Short name:
CMP-KDO synthaseUniRule annotation
Gene namesi
Name:kdsBUniRule annotationImported
ORF Names:RPSI07_0932Imported
OrganismiRalstonia solanacearum PSI07Imported
Taxonomic identifieri859657 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
Proteomesi
  • UP000006858 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliD8NZE0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the KdsB family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CET Bacteria
COG1212 LUCA
HOGENOMiHOG000007602
KOiK00979
OrthoDBiPOG091H00UN

Family and domain databases

CDDicd02517 CMP-KDO-Synthetase, 1 hit
Gene3Di3.90.550.10, 1 hit
HAMAPiMF_00057 KdsB, 1 hit
InterProiView protein in InterPro
IPR003329 Cytidylyl_trans
IPR004528 KdsB
IPR029044 Nucleotide-diphossugar_trans
PfamiView protein in Pfam
PF02348 CTP_transf_3, 1 hit
SUPFAMiSSF53448 SSF53448, 1 hit
TIGRFAMsiTIGR00466 kdsB, 1 hit

Sequencei

Sequence statusi: Complete.

D8NZE0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHAPFVAVI PARLASTRLP NKPLADIGGK PMVVRVAERA HQSSAARVVV
60 70 80 90 100
ATDAVSVADA CMQHHIEAVL TRADHASGTD RLAEVATVLA LPDDAIVVNV
110 120 130 140 150
QGDEPLIAPT LIDNVAAHLR DHADCAIATA AHPIHDAADI FNPNVVKVVL
160 170 180 190 200
DAAERAMLFS RAPLPWARDA WTPAVLGKPA AERPLPAMPV LRHIGIYAYR
210 220 230 240 250
AGFLRRFPQL AAAPLELTEQ LEQLRAMWHG ERIAVLTTDD APAAGVDTPE
260
DLARVRAAWS GLLSQDGP
Length:268
Mass (Da):28,559
Last modified:October 5, 2010 - v1
Checksum:i60D2AE071C62E768
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FP885906 Genomic DNA Translation: CBJ50292.1
RefSeqiWP_013211639.1, NC_014311.1

Genome annotation databases

EnsemblBacteriaiCBJ50292; CBJ50292; RPSI07_0932
KEGGirsl:RPSI07_0932

Similar proteinsi

Entry informationi

Entry nameiD8NZE0_RALSL
AccessioniPrimary (citable) accession number: D8NZE0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: September 27, 2017
This is version 52 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health