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D8MTA6 (D8MTA6_ERWBE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Chemotaxis response regulator protein-glutamate methylesterase HAMAP-Rule MF_00099
EC=3.1.1.61 HAMAP-Rule MF_00099
Gene names
Name:cheB HAMAP-Rule MF_00099 EMBL CAX60063.1
Ordered Locus Names:EbC_25320 EMBL CAX60063.1
OrganismErwinia billingiae (strain Eb661) [Complete proteome] [HAMAP]
Taxonomic identifier634500 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Erwinia ›

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR By similarity. HAMAP-Rule MF_00099 SAAS SAAS000673

Catalytic activity

Protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol. HAMAP-Rule MF_00099 SAAS SAAS000673

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00099.

Domain

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain By similarity. HAMAP-Rule MF_00099

Post-translational modification

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain By similarity. HAMAP-Rule MF_00099

Sequence similarities

Contains 1 cheB-type methylesterase domain. HAMAP-Rule MF_00099 SAAS SAAS000673

Contains 1 response regulatory domain. HAMAP-Rule MF_00099 SAAS SAAS000673

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain5 – 122118Response regulatory By similarity HAMAP-Rule MF_00099
Domain152 – 344193CheB-type methylesterase By similarity HAMAP-Rule MF_00099

Sites

Active site1641 By similarity HAMAP-Rule MF_00099
Active site1901 By similarity HAMAP-Rule MF_00099
Active site2861 By similarity HAMAP-Rule MF_00099

Amino acid modifications

Modified residue5614-aspartylphosphate By similarity HAMAP-Rule MF_00099

Sequences

Sequence LengthMass (Da)Tools
D8MTA6 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: 25FA55EEF9B58679

FASTA34937,320
        10         20         30         40         50         60 
MGKIRVLCVD DSALMRQLMT EIINSHADME MVASAPDPLV ARDMIKEFNP DVLTLDVEMP 

        70         80         90        100        110        120 
RMDGLDFLEK LMRLRPMPVV MVSSLTGKGS EVTLRALELG AVDFVTKPSL GIREGMLAYS 

       130        140        150        160        170        180 
QMIADKVRAA SRAKLHARGA QPAPVMLKAG PLLSSEKLIA IGASTGGTEA IRHVLQPLPA 

       190        200        210        220        230        240 
TSPALLITQH MPPGFTRSFA ERLNKLCQIT VKEAEDGERI LPGHAYIAPG AMHLELVRSG 

       250        260        270        280        290        300 
ANYQVKLNEG PPVNRHKPSV DVLFKSVAQY AGRNAVGVIL TGMGNDGAAG LLAMNKAGAW 

       310        320        330        340 
TIAQNEASCV VFGMPREAIA LGGASEVVDL HQISQHMLAK ISAGQALRI

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References

[1]"Genome comparison of the epiphytic bacteria Erwinia billingiae and E. tasmaniensis with the pear pathogen E. pyrifoliae."
Kube M., Migdoll A.M., Gehring I., Heitmann K., Mayer Y., Kuhl H., Knaust F., Geider K., Reinhardt R.
BMC Genomics 11:393-393(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Eb661 EMBL CAX60063.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		FP236843 Genomic DNA. Translation: CAX60063.1.
RefSeqYP_003741910.1. NC_014306.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAX60063; CAX60063; EbC_25320.
GeneID9427518.
KEGGebi:EbC_25320.
PATRIC42308073. VBIErwBil95213_2872.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000151423.
KOK03412.

Enzyme and pathway databases

BioCycEBIL634500:GHYX-2792-MONOMER.

Family and domain databases

Gene3D3.40.50.180. 1 hit.
HAMAPMF_00099. CheB_methylest.
InterProIPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
[Graphical view]
PfamPF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
[Graphical view]
PIRSFPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTSM00448. REC. 1 hit.
[Graphical view]
SUPFAMSSF52738. Chemotax_RR_pGlu_Me-esterase. 1 hit.
SSF52172. CheY_like. 1 hit.
PROSITEPS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD8MTA6_ERWBE
AccessionPrimary (citable) accession number: D8MTA6
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: May 1, 2013
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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