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Protein
Submitted name:

Dihydroorotate dehydrogenase A

Gene

pyrDA

Organism
Leuconostoc gasicomitatum (strain DSM 15947 / CECT 5767 / JCM 12535 / LMG 18811 / TB1-10)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.SAAS annotation

Cofactori

FMNSAAS annotationNote: Binds 1 FMN per subunit.SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei130 – 1301NucleophileUniRule annotation

GO - Molecular functioni

  1. dihydroorotate dehydrogenase activity Source: InterPro

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. UMP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseSAAS annotation

Keywords - Ligandi

Flavoprotein, FMNSAAS annotation

Enzyme and pathway databases

BioCyciLGAS762550:GHH1-1703-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Dihydroorotate dehydrogenase AImported
Gene namesi
Name:pyrDAImported
Ordered Locus Names:LEGAS_1084Imported
OrganismiLeuconostoc gasicomitatum (strain DSM 15947 / CECT 5767 / JCM 12535 / LMG 18811 / TB1-10)Imported
Taxonomic identifieri762550 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
ProteomesiUP000008706: Chromosome

Interactioni

Subunit structurei

Monomer.SAAS annotation

Family & Domainsi

Phylogenomic databases

HOGENOMiHOG000225104.
KOiK00226.
OMAiGLTLINC.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8MFW4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQLTANIQNY HFNHILLNAA GVMCQTSMEL DTVLASEYTG AVVTKSATPL
60 70 80 90 100
VRPGNPAPRY YELNNGLGTI NSMGLPNEGF DYYMDYVDTK ETYKPIFFSI
110 120 130 140 150
AGLSKQENIA MLHQLQDADF DGLIELNLSC PNVPGKPQTG YDFEATEQIL
160 170 180 190 200
TEVFAFFKKP LGVKLPPYFD IVHFDDIAAI LNKFPLAFVN TINSIGNGLV
210 220 230 240 250
IDQDTDTVVI KPKAGFGGIG GTLVKATALA NVRALRDRLN TTIKIIGTGG
260 270 280 290 300
VTTGRDVYDH LLCGADLVEV GSQLAIEGIT VFERLEKELT EILTEKGYDS
310
LDDVRGQLKI MS
Length:312
Mass (Da):34,110
Last modified:October 5, 2010 - v1
Checksum:iC9873F1B927B9A0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN822744 Genomic DNA. Translation: CBL91732.1.
RefSeqiYP_003772551.1. NC_014319.1.

Genome annotation databases

EnsemblBacteriaiCBL91732; CBL91732; LEGAS_1084.
GeneIDi9398606.
KEGGilgs:LEGAS_1084.
PATRICi42383844. VBILeuGas160647_1099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN822744 Genomic DNA. Translation: CBL91732.1.
RefSeqiYP_003772551.1. NC_014319.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBL91732; CBL91732; LEGAS_1084.
GeneIDi9398606.
KEGGilgs:LEGAS_1084.
PATRICi42383844. VBILeuGas160647_1099.

Phylogenomic databases

HOGENOMiHOG000225104.
KOiK00226.
OMAiGLTLINC.

Enzyme and pathway databases

BioCyciLGAS762550:GHH1-1703-MONOMER.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR012135. Dihydroorotate_DH_1_2.
IPR001295. Dihydroorotate_DH_CS.
[Graphical view]
PfamiPF01180. DHO_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
PROSITEiPS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence and comparative genomics of a food spoilage lactic acid bacterium Leuconostoc gasicomitatum 18811T."
    Johansson P., Paulin L., Vihavainen E.J., Salovuori N., Alatalo E.R., Bjoerkroth J.K., Auvinen P.
    Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 15947 / CECT 5767 / JCM 12535 / LMG 18811 / TB1-10Imported.

Entry informationi

Entry nameiD8MFW4_LEUGT
AccessioniPrimary (citable) accession number: D8MFW4
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: January 7, 2015
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.