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Protein
Submitted name:

Dihydroorotate dehydrogenase A

Gene

pyrDA

Organism
Leuconostoc gelidum subsp. gasicomitatum (strain DSM 15947 / CECT 5767 / JCM 12535 / LMG 18811 / TB1-10)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the conversion of dihydroorotate to orotate.SAAS annotation

Cofactori

FMNSAAS annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in the pathway UMP biosynthesis via de novo pathway, which is part of Pyrimidine metabolism.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseSAAS annotation
Biological processPyrimidine biosynthesisSAAS annotation
LigandFlavoprotein, FMNSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00070.

Names & Taxonomyi

Protein namesi
Submitted name:
Dihydroorotate dehydrogenase AImported
Gene namesi
Name:pyrDAImported
Ordered Locus Names:LEGAS_1084Imported
OrganismiLeuconostoc gelidum subsp. gasicomitatum (strain DSM 15947 / CECT 5767 / JCM 12535 / LMG 18811 / TB1-10)Imported
Taxonomic identifieri762550 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLeuconostocaceaeLeuconostoc
Proteomesi
  • UP000008706 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Interactioni

Protein-protein interaction databases

STRINGi762550.LEGAS_1084.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 293DHO_dhInterPro annotationAdd BLAST291

Sequence similaritiesi

Belongs to the dihydroorotate dehydrogenase family.SAAS annotation

Phylogenomic databases

eggNOGiENOG4107RY0. Bacteria.
COG0167. LUCA.
HOGENOMiHOG000225104.
KOiK00226.
OMAiMAKKGYE.
OrthoDBiPOG091H021X.

Family and domain databases

CDDicd04741. DHOD_1A_like. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR033886. DHOD_1A.
IPR005720. Dihydroorotate_DH.
IPR012135. Dihydroorotate_DH_1_2.
IPR001295. Dihydroorotate_DH_CS.
PfamiView protein in Pfam
PF01180. DHO_dh. 1 hit.
PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
PROSITEiView protein in PROSITE
PS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

D8MFW4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLTANIQNY HFNHILLNAA GVMCQTSMEL DTVLASEYTG AVVTKSATPL
60 70 80 90 100
VRPGNPAPRY YELNNGLGTI NSMGLPNEGF DYYMDYVDTK ETYKPIFFSI
110 120 130 140 150
AGLSKQENIA MLHQLQDADF DGLIELNLSC PNVPGKPQTG YDFEATEQIL
160 170 180 190 200
TEVFAFFKKP LGVKLPPYFD IVHFDDIAAI LNKFPLAFVN TINSIGNGLV
210 220 230 240 250
IDQDTDTVVI KPKAGFGGIG GTLVKATALA NVRALRDRLN TTIKIIGTGG
260 270 280 290 300
VTTGRDVYDH LLCGADLVEV GSQLAIEGIT VFERLEKELT EILTEKGYDS
310
LDDVRGQLKI MS
Length:312
Mass (Da):34,110
Last modified:October 5, 2010 - v1
Checksum:iC9873F1B927B9A0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN822744 Genomic DNA. Translation: CBL91732.1.
RefSeqiWP_010385793.1. NC_014319.1.

Genome annotation databases

EnsemblBacteriaiCBL91732; CBL91732; LEGAS_1084.
KEGGilgs:LEGAS_1084.
PATRICi42383844. VBILeuGas160647_1099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN822744 Genomic DNA. Translation: CBL91732.1.
RefSeqiWP_010385793.1. NC_014319.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi762550.LEGAS_1084.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCBL91732; CBL91732; LEGAS_1084.
KEGGilgs:LEGAS_1084.
PATRICi42383844. VBILeuGas160647_1099.

Phylogenomic databases

eggNOGiENOG4107RY0. Bacteria.
COG0167. LUCA.
HOGENOMiHOG000225104.
KOiK00226.
OMAiMAKKGYE.
OrthoDBiPOG091H021X.

Enzyme and pathway databases

UniPathwayiUPA00070.

Family and domain databases

CDDicd04741. DHOD_1A_like. 1 hit.
Gene3Di3.20.20.70. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR033886. DHOD_1A.
IPR005720. Dihydroorotate_DH.
IPR012135. Dihydroorotate_DH_1_2.
IPR001295. Dihydroorotate_DH_CS.
PfamiView protein in Pfam
PF01180. DHO_dh. 1 hit.
PIRSFiPIRSF000164. DHO_oxidase. 1 hit.
PROSITEiView protein in PROSITE
PS00911. DHODEHASE_1. 1 hit.
PS00912. DHODEHASE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiD8MFW4_LEUGG
AccessioniPrimary (citable) accession number: D8MFW4
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: January 18, 2017
This is version 48 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.