D8MCT0 (D8MCT0_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Leucine-rich repeat-containing G protein-coupled receptor 5 EMBL CBL95002.2

Submitted name:
Leucine-rich repeat-containing G-protein-coupled receptor 5 Ensembl ENSP00000443033

Gene names

Name:

LGR5 EMBL CBL95002.2 Ensembl ENSP00000443033

Organism

Homo sapiens (Human) [Reference proteome] EMBL CBL95002.2

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	835 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Domain	Leucine-rich repeat SAAS SAAS000372 Repeat SAAS SAAS000372
Molecular function	Receptor EMBL CBL95002.2
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	protein-hormone receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	D8MCT0 [UniParc]. Last modified October 5, 2010. Version 1. Checksum: 352096C4523C1E2F	FASTA	835	92,006
	10 20 30 40 50 60 MDTSRLGVLL SLPVLLQLAT GGSSPRSGVL LRGCPTHCHC EPDGRMLLRV DCSDLGLSEL 70 80 90 100 110 120 PSNLSVFTSY LDLSMNNISQ LLPNPLPSLR FLEELRLAGN ALTYIPKGAF TGLYSLKVLM 130 140 150 160 170 180 LQNNQLRHVP TEALQNLRSL QSLHLHNNRI HSLGKKCFDG LHSLETLDLN YNNLDEFPTA 190 200 210 220 230 240 IRTLSNLKEL GFHSNNIRSI PEKAFVGNPS LITIHFYDNP IQFVGRSAFQ HLPELRTLTL 250 260 270 280 290 300 NGASQITEFP DLTGTANLES LTLTGAQISS LPQTVCNQLP NLQVLDLSYN LLEDLPSFSV 310 320 330 340 350 360 CQKLQKIDLR HNEIYEIKVD TFQQLLSLRS LNLAWNKIAI IHPNAFSTLP SLIKLDLSSN 370 380 390 400 410 420 LLSSFPITGL HGLTHLKLTG NHALQSLISS ENFPELKVIE MPYAYQCCAF GVCENAYKIS 430 440 450 460 470 480 NQWNKGDNSS MDDLHKKDAG MFQAQDERDL EDFLLDFEED LKALHSVQCS PSPGPFKPCE 490 500 510 520 530 540 HLLDGWLIRI GVWTIAVLAL TCNALVTSTV FRSPLYISPI KLLIGVIAAV NMLTGVSSAV 550 560 570 580 590 600 LAGVDAFTFG SFARHGAWWE NGVGCHVIGF LSIFASESSV FLLTLAALER GFSVKYSAKF 610 620 630 640 650 660 ETKAPFSSLK VIILLCALLA LTMAAVPLLG GSKYGASPLC LPLPFGEPST MGYMVALILL 670 680 690 700 710 720 NSLCFLMMTI AYTKLYCNLD KGDLENIWDC SMVKHIALLL FTNCILNCPV AFLSFSSLIN 730 740 750 760 770 780 LTFISPEVIK FILLVVVPLP ACLNPLLYIL FNPHFKEDLV SLRKQTYVWT RSKHPSLMSI 790 800 810 820 830 NSDDVEKQSC DSTQALVTFT SSSITYDLPP SSVPSPAYPV TESCHLSSVA FVPCL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The finished DNA sequence of human chromosome 12." Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A., null. Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Alternatively spliced transcript of the GPR49-mRNA occur in different tumor cell lines and soft tissue sarcoma." Rot S., Taubert H., Bache M., Vordermark D., Kappler M. Submitted (APR-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC078860 Genomic DNA. No translation available. AC090116 Genomic DNA. No translation available. FN820440 mRNA. Translation: CBL95002.2.
IPI	IPI00970955.
RefSeq	NP_001264156.1. NM_001277227.1.
3D structure databases
SMR	D8MCT0. Positions 34-433.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000536515; ENSP00000443033; ENSG00000139292.
GeneID	8549.
UCSC	uc021rar.1. human.
Organism-specific databases
HGNC	HGNC:4504. LGR5.
GenAtlas	Search...
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR002131. Gphrmn_rcpt. IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. IPR000372. LRR-contain_N. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. PF00560. LRR_1. 2 hits. PF01462. LRRNT. 1 hit. [Graphical view]
PRINTS	PR00373. GLYCHORMONER. PR00237. GPCRRHODOPSN.
SMART	SM00369. LRR_TYP. 6 hits. SM00013. LRRNT. 1 hit. [Graphical view]
PROSITE	PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. PS51450. LRR. 12 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	35495810.

Entry information

Entry name

D8MCT0_HUMAN

Accession

Primary (citable) accession number: D8MCT0

Entry history

Integrated into UniProtKB/TrEMBL:	October 5, 2010
Last sequence update:	October 5, 2010
Last modified:	May 29, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.