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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

GSBLH_T00003801001

Organism
Blastocystis hominis
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).UniRule annotation

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.UniRule annotation

Cofactori

Protein has several cofactor binding sites:
  • [2Fe-2S] clusterUniRule annotationNote: Binds 1 [2Fe-2S] cluster.UniRule annotation
  • [3Fe-4S] clusterUniRule annotationNote: Binds 1 [3Fe-4S] cluster.UniRule annotation
  • [4Fe-4S] clusterUniRule annotationNote: Binds 1 [4Fe-4S] cluster.UniRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes fumarate from succinate (eukaryal route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (GSBLH_T00003962001), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (GSBLH_T00003920001), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (GSBLH_T00001115001), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (GSBLH_T00003258001), Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (GSBLH_T00002394001), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (GSBLH_T00000240001), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (GSBLH_T00000489001), Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (GSBLH_T00003801001)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes fumarate from succinate (eukaryal route), the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Ligand2Fe-2SUniRule annotation, 3Fe-4SUniRule annotation, 4Fe-4SUniRule annotation, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialUniRule annotation (EC:1.3.5.1UniRule annotation)
Gene namesi
ORF Names:GSBLH_T00003801001Imported
OrganismiBlastocystis hominisImported
Taxonomic identifieri12968 [NCBI]
Taxonomic lineageiEukaryotaStramenopilesBlastocystis
Proteomesi
  • UP000008312 Componenti: Unassembled WGS sequence

Subcellular locationi

  • Mitochondrion inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Matrix side UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 1102Fe-2S ferredoxin-typeInterPro annotationAdd BLAST83
Domaini154 – 1844Fe-4S ferredoxin-typeInterPro annotationAdd BLAST31

Sequence similaritiesi

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.UniRule annotation

Phylogenomic databases

InParanoidiD8M7G6.
OMAiESWIHTN.

Family and domain databases

CDDicd00207. fer2. 1 hit.
Gene3Di1.10.1060.10. 1 hit.
3.10.20.30. 1 hit.
InterProiView protein in InterPro
IPR036010. 2Fe-2S_ferredoxin-like_sf.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom_sf.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
PfamiView protein in Pfam
PF13085. Fer2_3. 1 hit.
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiView protein in PROSITE
PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

D8M7G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNYTVDMRVR EEMKMPCYKL FRIYRYNPAK DLKPHYESYV IDLMDCGTMV
60 70 80 90 100
LDALFKIKNE QDPTFAFRRS CREGICGSCA MNINGENGLA CLTKIPKNTD
110 120 130 140 150
ACTVRPLPHM FVIKDLIPDM TNFYEQYASI KPWLQKKSAV STDYKVENLQ
160 170 180 190 200
SHEDRLLLDG LYECILCACC STSCPSYWWH GDKYLGPSIL QQAYRWIADS
210 220 230 240 250
RDEMTEERLK SLDDTYKLYR CHAIMNCTHA CPKNLNPGRS IHKLKHAIHH

MH
Length:252
Mass (Da):29,415
Last modified:October 5, 2010 - v1
Checksum:iD0D35B23B1F2811D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FN668672 Genomic DNA. Translation: CBK24005.2.
RefSeqiXP_012898053.1. XM_013042599.1.

Genome annotation databases

EnsemblProtistsiCBK24005; CBK24005; GSBLH_T00003801001.
GeneIDi24920863.

Similar proteinsi

Entry informationi

Entry nameiD8M7G6_BLAHO
AccessioniPrimary (citable) accession number: D8M7G6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: December 20, 2017
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported