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Protein
Submitted name:

Myocyte enhancer factor 2c

Gene

MEF2C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotation

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Myocyte enhancer factor 2cImported
Submitted name:
Myocyte-specific enhancer factor 2CImported
Gene namesi
Name:MEF2CImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6996. MEF2C.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000081189.

PTM / Processingi

Proteomic databases

PeptideAtlasiD8L7E9.
PRIDEiD8L7E9.

Expressioni

Gene expression databases

ExpressionAtlasiD8L7E9. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000340874.

Structurei

3D structure databases

ProteinModelPortaliD8L7E9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61MADS-boxInterPro annotationAdd BLAST61

Sequence similaritiesi

Contains 1 MADS-box domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
GeneTreeiENSGT00390000011828.

Family and domain databases

CDDicd00265. MADS_MEF2_like. 1 hit.
InterProiIPR033896. MADS_MEF2-like.
IPR002100. TF_MADSbox.
[Graphical view]
PfamiPF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

D8L7E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS
60 70 80 90 100
TNKLFQYAST DMDKVLLKYT EYNEPHESRT NSDIVEAVPP PNFEMPVSIP
110 120 130 140 150
VSSHNSLVYS NPVSSLGNPN LLPLAHPSLQ RNSMSPGVTH RPPSAGNTGG
160 170 180 190 200
LMGGDLTSGA GTSAGNGYGN PRNSPGLLVS PGNLNKNMQA KSPPPMNLGM
210 220 230 240 250
NNRKPDLRVL IPPGSKNTMP SVSEDVDLLL NQRINNSQSA QSLATPVVSV
260 270 280 290 300
ATPTLPGQGM GGYPSAISTT YGTEYSLSSA DLSSLSGFNT ASALHLGSVT
310 320 330 340 350
GWQQQHLHNM PPSALSQLGD RTTTPSRYPQ HTRHEAGRSP VDSLSSCSSS
360 370 380 390
YDGSDREDHR NEFHSPIGLT RPSPDERESP SVKRMRLSEG WAT
Length:393
Mass (Da):42,471
Last modified:October 5, 2010 - v1
Checksum:iB7321ADBFFC64845
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008525 Genomic DNA. No translation available.
AC008835 Genomic DNA. No translation available.
FM180475 mRNA. Translation: CAQ86609.1.
RefSeqiNP_001180278.1. NM_001193349.1.
UniGeneiHs.649965.

Genome annotation databases

EnsembliENST00000626391; ENSP00000487184; ENSG00000081189.
GeneIDi4208.
UCSCiuc021ybg.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008525 Genomic DNA. No translation available.
AC008835 Genomic DNA. No translation available.
FM180475 mRNA. Translation: CAQ86609.1.
RefSeqiNP_001180278.1. NM_001193349.1.
UniGeneiHs.649965.

3D structure databases

ProteinModelPortaliD8L7E9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000340874.

Proteomic databases

PeptideAtlasiD8L7E9.
PRIDEiD8L7E9.

Protocols and materials databases

DNASUi4208.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000626391; ENSP00000487184; ENSG00000081189.
GeneIDi4208.
UCSCiuc021ybg.2. human.

Organism-specific databases

CTDi4208.
HGNCiHGNC:6996. MEF2C.
OpenTargetsiENSG00000081189.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
GeneTreeiENSGT00390000011828.

Miscellaneous databases

ChiTaRSiMEF2C. human.
GenomeRNAii4208.

Gene expression databases

ExpressionAtlasiD8L7E9. baseline and differential.

Family and domain databases

CDDicd00265. MADS_MEF2_like. 1 hit.
InterProiIPR033896. MADS_MEF2-like.
IPR002100. TF_MADSbox.
[Graphical view]
PfamiPF00319. SRF-TF. 1 hit.
[Graphical view]
PRINTSiPR00404. MADSDOMAIN.
SMARTiSM00432. MADS. 1 hit.
[Graphical view]
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiPS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiD8L7E9_HUMAN
AccessioniPrimary (citable) accession number: D8L7E9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.