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Protein
Submitted name:

Myocyte enhancer factor 2c

Gene

MEF2C

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotationSAAS annotation
Biological processTranscription, Transcription regulationPROSITE-ProRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Myocyte enhancer factor 2cImported
Submitted name:
Myocyte-specific enhancer factor 2CImported
Gene namesi
Name:MEF2CImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6996. MEF2C.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000081189.

Expressioni

Gene expression databases

ExpressionAtlasiD8L7E9. baseline and differential.

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 61MADS-boxInterPro annotationAdd BLAST61

Phylogenomic databases

eggNOGiKOG0014. Eukaryota.
COG5068. LUCA.
GeneTreeiENSGT00390000011828.

Family and domain databases

CDDicd00265. MADS_MEF2_like. 1 hit.
Gene3Di3.40.1810.10. 1 hit.
InterProiView protein in InterPro
IPR033896. MADS_MEF2-like.
IPR002100. TF_MADSbox.
PfamiView protein in Pfam
PF00319. SRF-TF. 1 hit.
PRINTSiPR00404. MADSDOMAIN.
SMARTiView protein in SMART
SM00432. MADS. 1 hit.
SUPFAMiSSF55455. SSF55455. 1 hit.
PROSITEiView protein in PROSITE
PS00350. MADS_BOX_1. 1 hit.
PS50066. MADS_BOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

D8L7E9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRKKIQITR IMDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNS
60 70 80 90 100
TNKLFQYAST DMDKVLLKYT EYNEPHESRT NSDIVEAVPP PNFEMPVSIP
110 120 130 140 150
VSSHNSLVYS NPVSSLGNPN LLPLAHPSLQ RNSMSPGVTH RPPSAGNTGG
160 170 180 190 200
LMGGDLTSGA GTSAGNGYGN PRNSPGLLVS PGNLNKNMQA KSPPPMNLGM
210 220 230 240 250
NNRKPDLRVL IPPGSKNTMP SVSEDVDLLL NQRINNSQSA QSLATPVVSV
260 270 280 290 300
ATPTLPGQGM GGYPSAISTT YGTEYSLSSA DLSSLSGFNT ASALHLGSVT
310 320 330 340 350
GWQQQHLHNM PPSALSQLGD RTTTPSRYPQ HTRHEAGRSP VDSLSSCSSS
360 370 380 390
YDGSDREDHR NEFHSPIGLT RPSPDERESP SVKRMRLSEG WAT
Length:393
Mass (Da):42,471
Last modified:October 5, 2010 - v1
Checksum:iB7321ADBFFC64845
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC008525 Genomic DNA. No translation available.
AC008835 Genomic DNA. No translation available.
FM180475 mRNA. Translation: CAQ86609.1.
RefSeqiNP_001180278.1. NM_001193349.1.
UniGeneiHs.649965.

Genome annotation databases

EnsembliENST00000626391; ENSP00000487184; ENSG00000081189.
GeneIDi4208.
UCSCiuc021ybg.2. human.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiD8L7E9_HUMAN
AccessioniPrimary (citable) accession number: D8L7E9
Entry historyiIntegrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: July 5, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported