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D8KPL3 (D8KPL3_CORPF) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 19. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
EC=6.3.4.13 HAMAP-Rule MF_00138
Alternative name(s):
GARS HAMAP-Rule MF_00138
Glycinamide ribonucleotide synthetase HAMAP-Rule MF_00138
Phosphoribosylglycinamide synthetase HAMAP-Rule MF_00138
Gene names
Name:purD HAMAP-Rule MF_00138
Ordered Locus Names:cpfrc_01737
OrganismCorynebacterium pseudotuberculosis (strain FRC41) [Complete proteome] [HAMAP]
Taxonomic identifier765874 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Corynebacteriaceae › Corynebacterium ›

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds (magnesium or manganese,ion) per subunit By similarity. HAMAP-Rule MF_00138

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family. HAMAP-Rule MF_00138

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00138

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain109 – 312204ATP-grasp By similarity HAMAP-Rule MF_00138
Nucleotide binding138 – 19356ATP By similarity HAMAP-Rule MF_00138

Sites

Metal binding2821Magnesium or manganese By similarity HAMAP-Rule MF_00138
Metal binding2841Magnesium or manganese By similarity HAMAP-Rule MF_00138

Sequences

Sequence LengthMass (Da)Tools
D8KPL3 [UniParc].

Last modified October 5, 2010. Version 1.
Checksum: E1163D7AB723ADAC

FASTA42243,756
        10         20         30         40         50         60 
MHILVIGSGA REHALALGLS KDPAVTEIHV APGNVGMESI ATVHAEATQV DDPDAMLKIA 

        70         80         90        100        110        120 
QETHADLVVV GPEIPLVAGV ADTLRAHGFA VFGPNKDAAQ IEGSKAFAKD VMAKAGVKTA 

       130        140        150        160        170        180 
RAEQIVPGAS DAEREAALDN FGPHYVVKDD GLAGGKGVVV TKDRAQARAH VDAVLAAGNP 

       190        200        210        220        230        240 
VLLESFLDGP EVSLFCLVDG ETVVPLLPAQ DHKRAHDNDE GPNTGGMGAY TPLPWLPEDG 

       250        260        270        280        290        300 
VQRIVDEVCV PVAREMVARG CAYSGLLYAG IAWGEDGPAV VEFNCRFGDP ETQAVLALLK 

       310        320        330        340        350        360 
TPLAGALHAV ATEKLAELPP LEWEDGYALT VVLAAEGYPQ NPRKGGEIVG AEDPAVLHAG 

       370        380        390        400        410        420 
TARDADGKLV AAGGRVLNVI GTGASLIEAR DKAYSVLNNI TLAGSHYRSD IALPAVEGKI 


TI

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References

[1]"The complete genome sequence of Corynebacterium pseudotuberculosis FRC41 isolated from a 12-year-old girl with necrotizing lymphadenitis reveals insights into gene-regulatory networks contributing to virulence."
Trost E., Ott L., Schneider J., Schroder J., Jaenicke S., Goesmann A., Husemann P., Stoye J., Alves Dorella F., Souza Rocha F., de Castro Soares S., D'Afonseca V., Miyoshi A., Ruiz J., Silva A., Azevedo V., Burkovski A., Guiso N. expand/collapse author list , Join-Lambert O.F., Kayal S., Tauch A.
BMC Genomics 11:728-728(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: FRC41.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP002097 Genomic DNA. Translation: ADK29530.1.
RefSeqYP_003784137.1. NC_014329.1.

3D structure databases

ProteinModelPortalD8KPL3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaADK29530; ADK29530; cpfrc_01737.
GeneID9449707.
KEGGcpu:cpfrc_01737.
PATRIC42279626. VBICorPse165161_1827.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHOG000033463.
KOK01945.
OMAMGAYTPL.

Enzyme and pathway databases

BioCycCPSE765874:GH5Y-1793-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
SSF51246. Rudmnt_hyb_motif. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameD8KPL3_CORPF
AccessionPrimary (citable) accession number: D8KPL3
Entry history
Integrated into UniProtKB/TrEMBL: October 5, 2010
Last sequence update: October 5, 2010
Last modified: May 1, 2013
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info